Lifeboat Foundation

Every time a new cancer drug is announced, it represents hundreds of researchers spending years behind the scenes working to design and test a new molecule. The drug has to be not only effective, but also as safe as possible and easy to manufacture—and these researchers have to choose among thousands of possible options for its chemical structure.

But building each possible molecular structure for testing is a laborious process, even if researchers simply want to change a single carbon atom.

A new technique published by University of Chicago chemists and the pharmaceutical company Merck & Co. in the journal Science offers a way to leapfrog that process, allowing scientists to quickly and easily produce new molecules of interest.

A team of astronomers led by University of Michigan’s Ian Roederer and including Carnegie’s Erika Holmbeck have identified the widest range of elements yet observed in a star beyond our own Sun. Their findings will be published in The Astrophysical Journal Supplement Series.

The researchers identified 65 elements in the star, which is called HD 222925. Of these, 42 are from the bottom of the periodic table. Their identification will help astronomers better understand rapid neutron capture process — one of the main methods by which the universe’s heavy elements were created.

“To the best of my knowledge, that’s a record for any object beyond our Solar System. And what makes this star so unique is that it has a very high relative proportion of the elements listed along the bottom two-thirds of the periodic table. We even detected gold,” explained Roederer, a former Carnegie postdoc. “These elements were made by the rapid neutron capture process. That’s really the thing we’re trying to study: the physics in understanding how, where and when those elements were made.”

Researchers at Princeton University have built the world’s smallest mechanically interlocked biological structure, a deceptively simple two-ring chain made from tiny strands of amino acids called peptides.

In a paper published August 23 in Nature Chemistry, the team detailed a library of such structures made in their lab—two interlocked rings, a ring on a dumbbell, a daisy chain and an interlocked double lasso—each around one billionth of a meter in size. The study also demonstrates that some of these structures can toggle between at least two shapes, laying the groundwork for a biomolecular switch.

“We’ve been able to build a bunch of structures that no one’s been able to build before,” said A. James Link, professor of chemical and biological engineering, the study’s principal investigator. “These are the smallest threaded or interlocking structures you can make out of peptides.”

The chemical composition and presence of metallic fragments also make lunar soil-less suitable for plant growth as compared to volcanic ash. However, the biggest takeaway from this experiment is still that scientists have somehow grown a plant in a soil sample taken from the Moon.

Emphasizing the importance of this result co-author and geologist Stephen Elardo said, from a geology standpoint, I look at this soil as being very very different from any soil you will find here on Earth. I think it’s amazing the plant still grows, right. It’s stressed, but it doesn’t die. It doesn’t fail to grow at all, it adapts.

Continue reading “Study reveals lunar soil can support plant growth” »

System represents a breakthrough in the real-life applicability of biophotovotaic devices.

Microprocessors can be powered using photosynthetic microorganisms in ambient light without the need for an external power source, new research shows. Led by Emre Ozer from Arm and Christopher Howe from the University of Cambridge, researchers in the UK, Italy and Norway introduced cyanobacteria Synechocystis sp. PCC6803 into an aluminium–air battery to create a biophotovoltaic device. The device is a similar size to an AA battery, is made from durable and mainly recyclable materials and does not require a dedicated light source to function. It is the first reported bioelectrochemical system capable of continuously powering a microprocessor outside of laboratory-controlled conditions.

‘We decided that we didn’t want to operate the system with a dedicated source of energy. We needed to prove that we can operate under ambient light, and we were able to do it,’ comments Paolo Bombelli, one of the lead researchers from the University of Cambridge.

Continue reading “Photosynthesis used to power a microprocessor for over six months” »

On account of the improvement the Internet of things (IoTs) and smart devices, our lives have been noticeably facilitated in the past few years. Machines and devices are becoming more ingenious with the help of artificial intelligence and various sensors^1,2. So, integrated circuits are necessary to provide convenient and effectual communication³ Since the first report on TENG by Wang’s group in 2012⁴, triboelectric systems have been recognized as a proper choice to harvest and convert the energy from the environment^5,6. Photodetectors, as one of the most significant types of sensors that can precisely convert incident light into electrical signals have attracted increasing attention in recent years. Various applications including photo-sensors, spectral analysis^7,8, environment monitoring⁹, communication devices¹⁰, imaging¹¹, take advantage of narrow band or broad band photodetectors from ultraviolet to terahertz wavelenght. Literature reviews show that the heterojunction/heterostructure based on 2D/3D materials have been widely used in PD applications. In fact, to attain high performance of PDs based heterojunction, the built-in electrical field is needed to suppress the photogenerated recombination and stimulating collection¹². Although, Si based PDs offer reliably high performance results, their complexity and expensive manufacturing process have limited their expansion and adoptability for industrial purposes^13,14,15. Hence, most available PDs are designed based on external power supplies such as electrochemical batteries for signal production and processing, their design not only increases the sensor’s dimension and weight, but also creates limitations for sensor maintenances¹⁶ which is not proper in the IoTs. In 2014, ZH Lin et al. and Zheng et al. represented an investigation on the self-powered PD based on TENG system^3,17, and since then, self-driven PDs have been extensively investigated^{2,5,9,18,19,20}. These devices can find potential applications in health monitoring systems such as heart checking²¹ and health protection from some detrimental radiation such as high levels of UV radiance²².

But in the other hand, even though TENGs could be promise for using in wearable electronics, they still inevitably have limitations in power generation, sensing range, sensitivity, and also the sensing domain for the intrinsic limitations of electrification^23,24,25. Moreover, due to high voltage, low current, and alternating current output of the TENGs, they cannot be used in order to supply power to electronic devices effectively without using power management circuits (PMCs) based on the LC modules. There are several reports that describe the importance of the impedance matching of the TENG and PMC units for better energy storage efficiency of the pulsed-TENG^26,27. Without using the PMC unit, there are some challenges as a result of synching the TENG, as the power supply, and the consumption element such as the PD device. These challenges include the process of matching the resistance of the device and the impedance of the TENG to achieve effective performance of the self-powered system^6,28.

In this study an efficient battery-free photodetector based on bulk heterojunction SnS₂ nanosheets and perovskite materials has been designed and powered employing three different TENGs (GO paper/ Kapton, FTO/Kapton and hand/ FTO). In the first step for circuit designing to have better performance of the photodetector in coupling with TENG, the effect load resistance amount in the circuit on the impedance matching the TENG and the inner resistance of the photodetector, has been investigated through output current amplitude. The investigation, shows that to achieve the high amount of the photocurrent, the load resistance should be positioned in both critical zone of the out-put voltage of the TENG and the resistance range of high power density production of the TENG. In the second step, for investigation the effect of the dark resistance of the photodetector on out-put current of the self-powered photodetector, a device with very lower initial resistance (All-oxide Cu₂O/ZnO photodetector) has been used with and without different load resistance in the circuit; in this regard, it is concluding that the initial resistance is too important to have proper design impedance matching circuit.

* Astrocytes play a variety of roles with neurons, but until now, scientists did not know that these cells carry electrical impulses.

* Applying new technology, Tufts University scientists recently discovered in mice that astrocytes are electrically active like neurons. Astrocytes play a variety of roles with neurons, but until now, scientists did not know that these cells carry electrical impulses.

Neurotransmitters are chemical messengers that facilitate the transfer of electrical signals between neurons and support the blood-brain barrier. Scientists have long understood that astrocytes control these substances to support neuronal health.

Continue reading “Researchers find new function performed by almost half of brain cells” »

Less than a millionth of a billionth of a second long, attosecond X-ray pulses allow researchers to peer deep inside molecules and follow electrons as they zip around and ultimately initiate chemical reactions.

Scientists at the Department of Energy’s SLAC National Accelerator Laboratory devised a method to generate X-ray laser bursts lasting hundreds of attoseconds (or billionths of a billionth of a second) in 2018. This technique, known as X-ray laser-enhanced attosecond pulse generation (XLEAP), enables researchers to investigate how electrons racing about molecules initiate key processes in biology, chemistry, materials science, and other fields.

“Electron motion is an important process by which nature can move energy around,” says SLAC scientist James Cryan. “A charge is created in one part of a molecule and it transfers to another part of the molecule, potentially kicking off a chemical reaction. It’s an important piece of the puzzle when you start to think about photovoltaic devices for artificial photosynthesis, or charge transfer inside a molecule.”

Unhackneyed compartmentalization generated by audible sound allows the enzyme reactions to be controlled spatiotemporally.

Spatiotemporal regulation of multistep enzyme reactions through compartmentalization is essential in studies that mimic natural systems such as cells and organelles. Until now, scientists have used liposomes, vesicles, or polymersomes to physically separate the different enzymes in compartments, which function as ‘artificial organelles’. But now, a team of researchers led by Director KIM Kimoon at the Center for Self-assembly and Complexity within the Institute for Basic Science in Pohang, South Korea successfully demonstrated the same spatiotemporal regulation of chemical reactions by only using audible sound, which is completely different from the previous methods mentioned above.

Although sound has been widely used in physics, materials science, and other fields, it has rarely been used in chemistry. In particular, audible sound (in the range of 20–20,000 Hz) has not been used in chemical reactions so far because of its low energy. However, for the first time, the same group from the IBS had previously successfully demonstrated the spatiotemporal regulation of chemical reactions through a selective dissolution of atmospheric gases via standing waves generated by audible sound back in 2020.