Lifeboat Foundation

How molecules change when they react to stimuli such as light is fundamental in biology, for example during photosynthesis. Scientists have been working to unravel the workings of these changes in several fields, and by combining two of these, researchers have paved the way for a new era in understanding the reactions of protein molecules fundamental for life.

The large international research team, led by Professor Jasper van Thor from the Department of Life Sciences at Imperial, report their results in the journal Nature Chemistry.

Crystallography is a powerful technique in structural biology for taking ‘snapshots’ of how molecules are arranged. Over several large-scale experiments and years of theory work, the team behind the new study integrated this with another technique that maps vibrations in the electronic and nuclear configuration of molecules, called spectroscopy.

While the current Oppenheimer blockbuster film focused on the destructive power of nuclear weapons, more peaceful uses of atomic propulsion for space exploration are now gaining once again momentum. ROB COPPINGER reports.

Nuclear fission and fusion power propulsion are under investigation in Europe and the US with an in-space engine demonstration planned by 2027 — with the news last month that Lockheed Martin had been selected to develop a nuclear thermal propulsion system for DARPA’s DRACO programme (see below).

Continue reading “Atomic rockets are back” »

Dr Kathryn Mumford is an Associate Professor in the Department of Chemical Engineering at the University of Melbourne, specialising in separation processes in ion exchange, solvent absorption and solvent extraction technologies. In collaboration with industry, her recent research has pioneered a more efficient, greener process to produce lithium carbonate.

Dr Mumford leads the Sustainable Resources platform, which focuses on research to support the transition to green energy, reduce environmental impact and develop smart mining and processing. Here, she discusses how the platform is tackling the industry’s greatest challenges, and the role the sector will play in decarbonising the world.

I’ve been thinking about sustainability and environmental health throughout my whole career. I saw the consequence of waste and was compelled to develop ways to reduce its impact. My PhD was around environmental clean-up, specifically cleaning up tip sites and fuel spills at contaminated sites in Antarctica – I’ve since been back to Antarctica seven times on clean-up missions.

Imagine a person on the ground guiding an airborne drone that harnesses its energy from a laser beam, eliminating the need for carrying a bulky onboard battery.

That is the vision of a group of University of Colorado at Boulder scientists from the Hayward Research Group.

In a new study, the Department of Chemical and Biological Engineering researchers have developed a novel and resilient photomechanical material that can transform light energy into mechanical work without heat or electricity, offering innovative possibilities for energy-efficient, wireless and remotely controlled systems. Its wide-ranging potential spans across diverse industries, including robotics, aerospace and biomedical devices.

I’d heard that fear of the dark is a protein, Scotophobin A, which can be isolated from the brains of rats. My Chemistry teacher told us that 1-hexanol smelled like cut grass. I watched her draw it once, on the whiteboard. A colorless liquid that, I imagined, smelled like memory, summer term, sports day, an army of ants cresting the summit of a picnic blanket, damp loam after rain.

I’d hoped that studying neuroscience would teach me all about things like that. I imagined watching sunlight refract through a conical flask, some clear liquid roiling inside. “Fear of abandonment is a sequence of seventeen peptides,” our lecturer might say, “isolated from the muscles of the heartbroken.”

“Look here,” he would say, pointing to another vial. “We can synthesize these things in a lab now. This one is awe.”

Two molecular languages at the origin of life have been successfully recreated and mathematically validated, thanks to pioneering work by Canadian scientists at Université de Montréal.

The study, “Programming chemical communication: allostery vs. multivalent mechanism,” published August 15, 2023 in the Journal of the American Chemical Society, opens new doors for the development of nanotechnologies with applications ranging from biosensing, drug delivery and molecular imaging.

Living organisms are made up of billions of nanomachines and nanostructures that communicate to create higher-order entities able to do many essential things, such as moving, thinking, surviving and reproducing.

Can you recognize someone you haven’t seen in years, but forget what you had for breakfast yesterday? Our brains constantly rearrange their circuitry to remember familiar faces or learn new skills, but the molecular basis of this process isn’t well understood. Today, scientists report that sulfate groups on complex sugar molecules called glycosaminoglycans (GAGs) affect “plasticity” in the brains of mice. Determining how GAGs function could help us understand how memory and learning work in humans, and provide ways to repair neural connectivity after injuries.

The researchers will present their results today at the fall meeting of the American Chemical Society (ACS).

The sugars that sweeten fruits, candies or cakes are actually just a few simple varieties of the many types of sugars that exist. When strung together, they can make a wide array of complex sugars. GAGs are formed by then attaching other chemical structures, including sulfate groups.

A study that peered into live mouse brains suggests for nearly 70 years we’ve been targeting the wrong neurons in our design of antipsychotic drugs.

Untangling the vast web of brain cells and determining how drugs work upon them is a tough task. Using a miniature microscope and fluorescent tags, a team of researchers led by Northwestern University neuroscientist Seongsik Yun discovered that effective antipsychotic drugs cling to a different type of brain cell than scientists originally thought.

Just like research suggesting depression might not be a chemical imbalance in serotonin levels, our understanding of schizophrenia treatments may need a rethink if widely-used antipsychotics are targeting different neurons than expected.

Canadian researchers at the University of Montreal have successfully recreated and mathematically confirmed two molecular languages at the origin of life.

Their groundbreaking findings, recently published in the Journal of American Chemical Society, pave the way for advancements in nanotechnologies, offering potential in areas like biosensing, drug delivery, and molecular imaging.

Living organisms are made up of billions of nanomachines and nanostructures that communicate to create higher-order entities able to do many essential things, such as moving, thinking, surviving, and reproducing.