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A sequence of stress signals among specialized clean-up cells in the brain could at last reveal why some immune responses can cause significant nerve degeneration that results in the loss of memory, judgement, and awareness behind Alzheimer’s disease.

Blocking this pathway in mouse brains modeled on Alzheimer’s prevented damage to their synapse connections and reduced the buildup of potentially toxic tau proteins – both hallmarks of the condition.

The researchers, led by a team from the City University of New York (CUNY), believe this pathway – called the integrated stress response (ISR) – causes brain immune cells called microglia to go ‘dark’ and start damaging rather than benefiting the brain.

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A blood test that can predict how long vaccine immunity will last so people can get a booster jab earlier, is being developed by scientists.

Researchers have previously been unable to predict why some vaccines produce antibodies to fight infections that last for decades while in others immunity only lasts a few months.

Now Stanford University has found tell-tale signs in the blood in the days after vaccination to indicate how quickly a person’s antibody protection will wane.

Researchers have discovered nanocrystals that toggle between luminescent states swiftly, offering a promising advancement toward optical computing.

This technology could revolutionize data processing and artificial intelligence, making devices faster and more energy-efficient while expanding capabilities in telecommunications and medical imaging.

Breakthrough in Nanocrystal Technology.

Scientists at the Francis Crick Institute have generated human stem cell models1 which, for the first time, contain notochord – a tissue in the developing embryo that acts like a navigation system, directing cells where to build the spine and nervous system (the trunk).

A new study from Vanderbilt University Medical Center shows that clinical alerts driven by artificial intelligence (AI) can help doctors identify patients at risk for suicide, potentially improving prevention efforts in routine medical settings.

A team led by Colin Walsh, MD, MA, associate professor of Biomedical Informatics, Medicine and Psychiatry, tested whether their AI system, called the Vanderbilt Suicide Attempt and Ideation Likelihood model (VSAIL), could effectively prompt doctors in three neurology clinics at VUMC to screen patients for suicide risk during regular clinic visits.

The study, reported in JAMA Network Open, compared two approaches—automatic pop-up alerts that interrupted the doctor’s workflow versus a more passive system that simply displayed risk information in the patient’s electronic chart.

The World Health Organization (WHO) has declared the mpox outbreak in parts of Africa a public health emergency of international concern.

The highly contagious disease — formerly known as monkeypox — has killed at least 450 people during an initial outbreak in the Democratic Republic of Congo.

It has now spread across parts of central and east Africa, and scientists are concerned about how fast a new variant of the disease is spreading and its high fatality rate.

Gramicidins work as antibiotics against gram-positive bacteria like Bacillus subtilis and Staphylococcus aureus, but not well against gram-negative ones like E. coli. [ 3 ]

Gramicidins are used in medicinal lozenges for sore throat and in topical medicines to treat infected wounds.s are often mixed with other antibiotics like tyrocidine and antiseptics. [ 4 ] s are also used in eye drops for bacterial eye infections. In drops, they are often mixed with other antibiotics like polymyxin B or neomycin. Multiple antibiotics increase efficiency against various strains of bacteria. [ 5 ] Such eye-drops are also used to treat eye infections of animals, like horses. [ 6 ]

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Image credit: GrumpyBeere – Pixabay

Researchers used a refined method of ancestry analysis utilizing ancient DNA. This study represents a significant advancement in our understanding of historical population movements.

Researchers can trace human migration through DNA changes, but it’s challenging when historical groups are genetically similar.

Meanwhile, scientists dug into how psychedelics and MDMA fight off depression and post-traumatic stress disorders. The year was a relative setback for the psychedelic renaissance, with the FDA rejecting MDMA therapy. But the field is still gaining recognition for its therapeutic potential.

Then there’s lenacapavir, a shot that protects people from HIV. Named “breakthrough of the year” by Science, the shot completely protected African teenage girls and women against HIV infection. Another trial supported the results, showing the drug protected people who have sex with men at nearly 100 percent efficacy. The success stems from a new understanding of the protein “capsule” guarding the virus’ genetic material. Many other viruses have a similar makeup—meaning the strategy could help researchers design new drugs to fight them off too.

So, what’s poised to take the leap from breakthrough to clinical approval in 2025? Here’s what to expect in the year ahead.