Researchers have identified new variations in neuroblastoma that could lead to a more accurate prognosis and better-targeted treatments for this devastating childhood cancer.
For many of these individuals, the response to repotrectinib lasted for several years.
“Repotrectinib can lead to long-term responses for patients with ROS1 fusion–positive lung cancers, including those who have and have not received prior targeted therapy,” said Alexander Drilon, M.D., of Memorial Sloan Kettering Cancer Center, who led the TRIDENT-1 study.
Treatment with repotrectinib also shrank tumors that had spread to the brain, a common location for lung metastases, the researchers reported.
Researchers at Tel Aviv University (TAU) and the Leviev Cardiothoracic and Vascular Center at the Sheba Medical Center have found a mechanism responsible for increasing the risk of developing cancer among patients with heart disease: Small extracellular bubbles, or vesicles (sEVs), secreted from the sick heart to heal itself, are released into the bloodstream and promote the growth of cancer cells throughout the body.
Synchron on Monday plans to launch an online…
WASHINGTON, April 8 (Reuters) — Synchron Inc, a rival to Elon Musk’s Neuralink brain implant startup, is preparing to recruit patients for a large-scale clinical trial required to seek commercial approval for its device, the company’s chief executive told Reuters.
Synchron on Monday plans to launch an online registry for patients interested in joining the trial meant to include dozens of participants, and has received interest from about 120 clinical trial centers to help run the study, CEO Thomas Oxley said in an interview.
Personalized vaccine + immunotherapy cuts advanced liver cancer in small trial.
There were no serious adverse reactions. The most common was mild injection site reactions.
This Geneos treatment is a DNA vaccine that delivers the genetic code of mutated proteins into cells through a small electrical impulse. Each vaccine can target up to 40 mutated genes.
Continue reading “Geneos vaccine shows efficacy in reducing liver tumors in trial” »
Mitochondria, organelles with an inner and outer membrane, are responsible for creating the energy that cells use to survive, and their morphology is key to accomplishing this task. The inner mitochondrial membrane contains folds, called cristae, that maximize the surface area available for mitochondrial energetic processes.
Recent research in mice investigates a new, immunotherapy-based approach to treating Alzheimer’s disease aiming to clear toxic protein accumulations in the brain.
“It’s not much you can do about it. Other than fight it and if you fight and you quit, then you are not gonna make it,” he said.
The founders of this Malibu-based class say it challenges the mind and body to work together, getting stronger in the process.
John Wakefield, the creator and co-founder of drumboxing in California, told KCBS, “The connection with rhythm, tying it in with motor skills, really training the brain like you train the body putting it in a situation where it has to react.”
A medication used to treat diabetes appeared to halt the progression of Parkinson’s symptoms in a phase 2 trial of people in the early stages of the disease. While more research is needed to see how large the effect is and how long it might last, the news is encouraging in the hunt for new Parkinson’s treatments.
The challenge: More than 8.5 million people worldwide are living with Parkinson’s, a progressive neurodegenerative disease caused by the loss of brain cells that produce dopamine, which helps neurons communicate.
Common Parkinson’s symptoms include tremors, stiffness, and impaired cognition. Meds that replace dopamine can help alleviate those, but they don’t address the underlying cause — the loss of dopamine neurons — and so the disease progresses.
A nanosized polymer, developed by a research team from Ben-Gurion University of the Negev, can selectively deliver chemotherapeutic drugs to blood vessels that feed tumors and metastases and has emerged as an effective treatment for advanced cancer. The polymer eliminates colorectal cancer liver metastases and prolongs mice survival after a single dose therapy.
