Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical – Page 86

New research reveals how male and female brains process regret and change decisions

A traditionally overlooked type of RNA plays an important role in promoting resilience to depression—but only in females. According to a new study led by the Icahn School of Medicine at Mount Sinai, researchers have now discovered a novel role this molecule plays in how the female brain makes decisions. The authors revealed brain-region-specific and sex-dependent effects of this biomarker, translated from humans to animals, on how individuals make only certain types of choices. This study uncovered differences in how each sex decides whether to change their minds after making mistakes, including when to cut their losses and move on as well as how they process regrets about missed opportunities.

This research sheds important light on how specific types of decisions that could negatively impact mood engage the male and female brain in very different ways. The study, published July 11 in Science Advances, using laboratory animal models, helps uncover new biological and psychological mechanisms that may be linked to psychiatric vulnerabilities.

Women are twice as likely to develop depression than men. Furthermore, depression can manifest with different symptoms between the sexes, including alterations in negative rumination on the past. However, the neurobiological mechanisms underlying these differences remain unclear.

Role of plasmin in metastatic tumors

FasL is an immune cell membrane protein that triggers a programmed cell death called apoptosis. Activated immune cells, including CAR-T cells made from a patient’s immune system, use apoptosis to kill cancer cells.

The team discovered that in human genes, a single evolutionary amino acid change — serine instead of proline at position 153 — makes FasL more susceptible to being cut and inactivated by plasmin.

Plasmin is a protease enzyme that is often elevated in aggressive solid tumors like triple negative breast cancer, colon cancer and ovarian cancer.

This means that even when human immune cells are activated and ready to attack the tumor cells, one of their key death weapons — FasL — can be neutralized by the tumor environment, reducing the effectiveness of immunotherapies.

The findings may help explain why CAR-T and T-cell-based therapies can be effective in blood cancers but often fall short in solid tumors. Blood cancers often do not rely on plasmin to metastasize, whereas tumors like ovarian cancer rely heavily on plasmin to spread the cancer.

Significantly, the study also showed that blocking plasmin or shielding FasL from cleavage can restore its cancer-killing power. That finding may open new doors for improving cancer immunotherapy.

Continue reading “Role of plasmin in metastatic tumors” | >

How the genome defends itself against internal enemies

An international research team has deciphered a mechanism of the evolutionary arms race in human cells. The findings provide insights into how mobile elements in DNA hijack cellular functions—and how cells can defend themselves against this in order to prevent conditions such as tumor formation or chronic inflammation.

An international research team led by Freiburg biologists Dr. Wenjing Qi and Prof. Ralf Baumeister has discovered how the LINE1 retrotransposon exploits a to become active itself, as occurs in tumors. At the same time, the researchers have also deciphered the cell’s appropriate countermeasures to prevent conditions such as or chronic inflammation. The results have been published in the journal Nature Communications.

Wristband sensor provides all-in-one monitoring for diabetes and cardiovascular care

A new wearable wristband could significantly improve diabetes management by continuously tracking not only glucose but also other chemical and cardiovascular signals that influence disease progression and overall health. The technology was published in Nature Biomedical Engineering.

The flexible wristband consists of a microneedle array that painlessly samples interstitial fluid under the skin to measure glucose, lactate and alcohol in real time using three different enzymes embedded within the tiny needles. Designed for easy replacement, the microneedle array can be swapped out to tailor wear periods. This reduces the risk of allergic reactions or infection while supporting longer-term use.

Simultaneously, the wristband uses an ultrasonic sensor array to measure and arterial stiffness, while ECG sensors measure heart rate directly from wrist pulses. These physiological signals are key indicators of cardiovascular risk, which is often elevated in people with diabetes but is rarely monitored continuously outside of a clinical setting.

DunedinPACNI estimates the longitudinal Pace of Aging from a single brain image to track health and disease

Differences in the Pace of Aging are important for many health outcomes but difficult to measure. Here the authors describe the Dunedin Pace of Aging Calculated from NeuroImaging measure, an approach that uses a single brain image to measure how fast a person is aging and can help predict mortality or the risk of developing chronic disease.

AI-assisted technique can measure and track aging cells

A combination of high-resolution imaging and machine learning, also known as artificial intelligence (AI), can track cells damaged from injury, aging, or disease, and that no longer grow and reproduce normally, a new study shows.

These senescent cells are known to play a key role in wound repair and aging-related diseases, such as cancer and heart disease, so tracking their progress, researchers say, could lead to a better understanding of how tissues gradually lose their ability to regenerate over time or how they fuel disease. The tool could also provide insight into therapies for reversing the damage.

The study included training a computer system to help analyze animal cells damaged by increasing concentrations of chemicals over time to replicate human aging. Cells continuously confronted with environmental or biological stress are known to senesce, meaning they stop reproducing and start to release telltale molecules indicating that they have suffered injury.

Permanent retention of exceptional trees can improve ecosystem integrity in managed forests

Even-aged forest management is geared towards timber production with ecosystem health as a lesser consideration. This creates a dichotomy where forests are treated either as plantations or reserves. Uneven-aged management can bring compromise to conflicting land uses by reducing ecosystem impacts while still allowing timber extraction. Whereas selection forestry focuses on which trees are taken, retention forestry focuses on protecting features that will remain after logging. These biological legacies provide ecosystem continuity.

Retained trees are often chosen based on their habitat value. Snags and living trees that are diseased, damaged, or dying provide cavities, decaying wood, and other microhabitats for a diversity of biota. Defects that make high-quality habitat trees tend to cause the collapse of large and , so it’s important to designate healthy recruitment trees for the future. Retention forestry that focuses only on habitat trees may be inconsistent with the goals of long-term carbon storage and ecosystem resilience.

An article just published in Forest Ecology and Management explores the idea of “exceptional trees” and why we might consider choosing a subset of the most robust trees for permanent retention in managed forests. We present methods for precisely estimating aboveground biomass across the landscape and assess the contribution of exceptional trees to biomass and productivity. Our study focuses on Sequoia sempervirens (redwood) in California’s Demonstration State Forests.

/* */