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AI Used to Predict Potential New Antibiotics

A new study used machine learning to predict potential new antibiotics in the global microbiome, which study authors say marks a significant advance in the use of artificial intelligence in antibiotic resistance research…

For this study, the researchers collected genomes and meta-genomes stored in publicly available databases and looked for DNA snippets that could have antimicrobial activity. To validate those predictions, they used chemistry to synthesize 100 of those molecules in the laboratory and then test them to determine if they could actually kill bacteria, including ‘some of the most dangerous pathogens in our society’, de la Fuente said.

New study reveals gut microbiome’s critical role in aging and heart disease

🧬❤️👩‍🔬 https://www.news-medical.net/news/20240609/New-study-reveals…al-role-in


In a recent study published in the journal Nature Medicine, a team of researchers in China conducted a prospective analysis of metabolic multimorbidity clusters based on 21 metabolic parameters to investigate gut microbiome signatures associated with metabolism and age to better understand the relationship between metabolism, age, and the long term risk of cardiovascular disease.

Study: Divergent age-associated and metabolism-associated gut microbiome signatures modulate cardiovascular disease risk. Image Credit: Kateryna Kon / Shutterstock.

Background

Cardiovascular disease is the major cause of global mortality, and metabolic perturbations and age, which are also intricately connected, are believed to contribute significantly to the risk of cardiovascular disease. Metabolic disturbances increase in complexity and prevalence with age, and older adults typically develop cardiovascular disease in a multimorbidity context.

Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex

Year 2022 This can lead to even greater understanding of the human brain with organiods in mice.


Neuron al organoids derived from human induced pluripotent stem cells can be transplanted and integrated into the rodent cortex for the study of brain development and function. Here the authors demonstrate use of transparent graphene microelectrodes and two photon imaging for longitudinal, multimodal monitoring of functional connectivity between human iPSC derived neuronal organoids and the mouse cortex.

Game-Changing Antibiotic Discovered That Spares ‘Good’ Bacteria

For all the good antibiotics do for the world, one of the biggest downsides to their use is the way they indiscriminately kill both the ‘good’ and the ‘bad’

A single course of this life-saving medicine can not only destroy disease-causing invaders in the human body; it can also have an “immense” impact on the gut and its resident collection of microbes.

This impact can sometimes lead to an overgrowth of certain bacteria or fungi. For instance, women have up to a 30 percent chance of developing a yeast infection after antibiotic treatment.

Celiac Disease: New Findings on the Effects of Gluten

New details on how certain gluten-derived molecules trigger leaky gut syndrome in affected individuals. Celiac disease is a chronic autoimmune condition that occurs in around one per cent of the world’s population. It is triggered by the consumption of gluten proteins from wheat, barley, rye and some oats. A gluten-free diet protects celiac patients from severe intestinal damage. Together with colleagues, chemist Dr Veronica Dodero from Bielefeld University was able to determine new details on how certain gluten-derived molecules trigger leaky gut syndrome in celiac disease.

China: Robot doctors at world’s 1st AI hospital can treat 3,000 a day

China’s first AI hospital, developed by Tsinghua University, features robot doctors capable of treating 3,000 patients daily, vastly outpacing human capacity.

These AI doctors, trained in a simulated environment, can diagnose and treat 10,000 patients in days, a task humans would need two years to…


China debuts an AI hospital town featuring AI doctors caring for virtual patients to advance medical consultation and evolve doctor agents.

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