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Category: biotech/medical – Page 821

Milk and colostrum have high biological potential, and due to their natural origin and non-toxicity, they have many uses in cosmetics and dermatology. Research is ongoing on their potential application in other fields of medicine, but there are still few results; most of the published ones are included in this review. These natural products are especially rich in proteins, such as casein, β-lactoglobulin, α-lactalbumin, lactoferrin, immunoglobulins, lactoperoxidase, lysozyme, and growth factors, and possess various antibacterial, antifungal, antiviral, anticancer, antioxidant, immunomodulatory properties, etc. This review describes the physico-chemical properties of milk and colostrum proteins and the natural functions they perform in the body and compares their composition between animal species (cows, goats, and sheep). The milk-and colostrum-based products can be used in dietary supplementation and for performing immunomodulatory functions; they can enhance the effects of certain drugs and can have a lethal effect on pathogenic microorganisms. Milk products are widely used in the treatment of dermatological diseases for promoting the healing of chronic wounds, hastening tissue regeneration, and the treatment of acne vulgaris or plaque psoriasis. They are also increasingly regarded as active ingredients that can improve the condition of the skin by reducing the number of acne lesions and blackheads, regulating sebum secretion, ameliorating inflammatory changes as well as bestowing a range of moisturizing, protective, toning, smoothing, anti-irritation, whitening, soothing, and antiaging effects.

Keywords: milk, colostrum, casein, β-lactoglobulin, α-lactalbumin, lactoferrin, growth factors, skin, regeneration, antimicrobial, cosmetics.

Although milk is known to be used as a raw material in the food industry, it is also widely used in the pharmaceutical and cosmetic industries due to its considerable biological potential. It has also been the subject of detailed analyses and discussions of its individual components and their properties [1, 2].

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A CAR T-cell therapy targeting disease-driving immune cells safely led to sustained disease remission for five people with systemic lupus erythematosus (SLE) who’d previously failed to respond to other treatments, a recent study reported.

Treatment was also highly specific, preventing autoimmune activity, but didn’t impair general immune system function.

“These data provide new therapeutic possibilities to control SLE disease activity,” the researchers wrote. “Longer follow-ups in larger cohorts of patients will be necessary to confirm sustained absence of autoimmunity and resolution of inflammation in patients with SLE who have received CAR T cell therapy.”

Nature Abstract.

https://www.nature.com/articles/s41591-022-02017-5

No systemic lupus erythematosus patient receiving the CAR T-cell therapy infusion relapsed, all remained in remission for up to 17 months.

Continue reading “5 SLE Patients See Disease Remission With CAR T-cell Therapy” | >

Engineering T cells to destroy cancer cells has shown success in treating some types of cancer, such as leukemia and lymphoma. However, it hasn’t worked as well for solid tumors.

One reason for this lack of success is that the T cells target only one antigen (a target protein found on the tumors); if some of the tumor cells don’t express that antigen, they can escape the T cell attack.

MIT researchers have now found a way to overcome that obstacle, using a vaccine that boosts the response of engineered T cells, known as chimeric antigen receptor (CAR) T cells, and also helps the immune system generate new T cells that target other tumor antigens. In studies in mice, the researchers found that this approach made it much more likely that tumors could be eradicated.

A new vaccine boosts the response of engineered CAR-T cells and helps the immune system generate T cells that target other tumor antigens. The researchers found this approach made it more likely that a tumor can be eradicated in mice.

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Conclusions.

The vectorial role of bat flies should be checked by testing the same pathogen and bacterial organisms by collecting blood from host bats. This study is of great interest in the fields of disease ecology and public health owing to the bats’ potential to transmit pathogens to humans and/or livestock.

Covid is a bat bourne disease from such zoonotic transmission.

Background Bats are hosts for many ectoparasites and act as reservoirs for several infectious agents, some of which exhibit zoonotic potential. Here, species of bats and bat flies were identified and screened for microorganisms that could be mediated by bat flies. Methods Bat species were identified on the basis of their morphological characteristics. Bat flies associated with bat species were initially morphologically identified and further identified at the genus level by analyzing the cytochrome c oxidase subunit I gene. Different vector-borne pathogens and endosymbionts were screened using PCR to assess all possible relationships among bats, parasitic bat flies, and their associated organisms. Results Seventy-four bat flies were collected from 198 bats; 66 of these belonged to Nycteribiidae and eight to Streblidae families.

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In a way, the brain changes its channels as we go about our day to match our internal state of mind to outside requirements—though at any point, the channels can bleed over.

But there’s a mysterious outcast: a frequency called theta waves. They happen while we’re awake or asleep. For decades, these waves have taunted neuroscientists trying to decipher their functions. Theta waves seem to help mice navigate mazes, but also support memory in humans.

It’s not just academic curiosity. Our ability to navigate complex new environments and keep those memories declines with age. It’s especially tough for people with Alzheimer’s disease. By finding the driving source of theta waves, we could potentially enhance them—using neurostimulation or other methods—to slow cognitive decline.

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Continue reading “Niacin Increases NAD (Test Results)” | >

A consortium of scientists has just published an atlas of remarkable images of three human organs, each vital in their own way, showing how cell types are arranged and interact.

The result: Glittering, kaleidoscopic blueprints lit up by fluorescent dyes that reveal new intimacies about our bodies and reshape our understanding of human biology and disease like never before.

As you can see in the diagram below, researchers generated the cell atlases in three ways.

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