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Category: biotech/medical – Page 438

Is fungi our secret tool against antibiotic resistance?

face_with_colon_three fungi is even better than current medicines and frankly better for you. We can also ingest fungi that can help be a natural food medicine to help prevent worse diseases.

While all attention is on the pandemic right now, the SARS-CoV-2 virus isn’t the only microbial threat we face.

While we’re all rightly focused on the COVID-19 pandemic at the moment, the SARS-CoV-2 virus isn’t the only microbial threat we face.

Back in 2014, the World Health Organization (WHO) warned that within a decade, antibiotic-resistant bacteria could make routine surgery, organ transplantation and cancer treatment life-threateningly risky — and spell the end of modern medicine as we know it.

United Nations General Assembly’s AUDACITY 100 Disruptors Summit

face_with_colon_three Fungi can save all life on earth. This lecture teaches that mushrooms are outperforming even age old medicines.

Watch my 15 minute speech at the United Nations General Assembly’s AUDACITY 100 Disruptors Summit was a powerful reminder of how interconnected we all are.

I spoke about how fungal mycelium can help heal ecosystems, strengthen food systems, and strengthens the health.
of the residents of the planet. Mycelium supports our collective immunity.

When Mycelium Running: How Mushrooms Can Help Save the World was published in 2005, it foretold the mycelial revolution that continues to sweep the planet. This book is as relevant today as it was then. What has happened since? The scientific community continues to verify that mycelium is essential for our collective health, whether as nutritional supplements, or as the core fabric of our food webs.

Scientists map DNA folding at single base-pair resolution in living cells

Scientists from Oxford’s Radcliffe Department of Medicine have achieved the most detailed view yet of how DNA folds and functions inside living cells, revealing the physical structures that control when and how genes are switched on.

Using a new technique called MCC ultra, the team mapped the down to a single base pair, unlocking how genes are controlled, or, how the body decides which genes to turn on or off at the right time, in the right cells. This breakthrough gives scientists a powerful new way to understand how lead to disease and opens up fresh routes for drug discovery.

“For the first time, we can see how the genome’s control switches are physically arranged inside cells, said Professor James Davies, lead author of the study published in the journal Cell titled ” Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions.”

AI-designed antibodies created from scratch

Research led by the University of Washington reports on an AI-guided method that designs epitope-specific antibodies and confirms atomically precise binding using high-resolution molecular imaging, then strengthens those designs so the antibodies latch on much more tightly.

Antibodies dominate modern therapeutics, with more than 160 products on the market and a projected value of US$445 billion in 5 years. Antibodies protect the body by locking onto a precise spot—an epitope—on a virus or toxin.

That pinpoint connection determines whether an antibody blocks infection, marks a pathogen for removal, or neutralizes a harmful protein. When a drug antibody misses its intended epitope, treatment can lose power or trigger side effects by binding the wrong target.

Textbook view of NMDA receptor calcium signals upended by new findings

Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders. These drugs were developed based on the assumption that the proportion of calcium in the current produced by these receptors remains constant. That assumption turns out to be false, according to University at Buffalo research published last month in the Proceedings of the National Academy of Sciences.

“Our research reveals that small variations in the brain environment in which NMDA receptors operate can increase or decrease the amount of in the currents fluxed by these receptors,” explains Gabriela K. Popescu, Ph.D., corresponding author and professor of biochemistry in the Jacobs School of Medicine and Biomedical Sciences at UB. “This, in turn, could mean the difference between normal and impaired learning, memory and cognition, symptoms that accompany many neuropsychiatric conditions.”

Quantum ‘pinball’ state of matter in electrons allows both conducting and insulating properties, physicists discover

Electricity powers our lives, including our cars, phones, computers, and more, through the movement of electrons within a circuit. While we can’t see these electrons, electric currents moving through a conductor flow like water through a pipe to produce electricity.

Certain materials, however, allow that electron flow to “freeze” into crystallized shapes, triggering a transition in the state of matter that the electrons collectively form. This turns the material from a conductor to an insulator, stopping the flow of electrons and providing a unique window into their complex behavior. This phenomenon makes possible new technologies in quantum computing, advanced superconductivity for energy and medical imaging, lighting, and highly precise atomic clocks.

A team of Florida State University-based physicists, including National High Magnetic Field Laboratory Dirac Postdoctoral Fellow Aman Kumar, Associate Professor Hitesh Changlani and Assistant Professor Cyprian Lewandowski, have shown the conditions necessary to stabilize a phase of matter in which electrons exist in a solid crystalline lattice but can “melt” into a , known as a generalized Wigner crystal. Their work was published in npj Quantum Materials.

Physicists observe key evidence of unconventional superconductivity in magic-angle graphene

Superconductors are like the express trains in a metro system. Any electricity that “boards” a superconducting material can zip through it without stopping and losing energy along the way. As such, superconductors are extremely energy efficient, and are used today to power a variety of applications, from MRI machines to particle accelerators.

But these “conventional” superconductors are somewhat limited in terms of uses because they must be brought down to ultra-low temperatures using elaborate cooling systems to keep them in their superconducting state.

If superconductors could work at higher, room-like temperatures, however, they would enable a new world of technologies, from zero-energy-loss power cables and electricity grids, to practical quantum computing systems. And so, scientists at MIT and elsewhere are studying “unconventional” superconductors—materials that exhibit in ways that are different from and potentially more promising than today’s superconductors.

A new patch could help to heal the heart

MIT engineers have developed a flexible drug-delivery patch that can be placed on the heart after a heart attack to help promote healing and regeneration of cardiac tissue.

The new patch is designed to carry several different drugs that can be released at different times, on a pre-programmed schedule. In a study of rats, the researchers showed that this treatment reduced the amount of damaged heart tissue by 50 percent and significantly improved cardiac function.

If approved for use in humans, this type of patch could help heart attack victims recover more of their cardiac function than is now possible, the researchers say.

Common Sweetener Could Damage Critical Brain Barrier, Risking Stroke

Found in everything from protein bars to energy drinks, erythritol has long been considered a safe alternative to sugar.

But research suggests this widely used sweetener may be quietly undermining one of the body’s most crucial protective barriers – with potentially serious consequences for heart health and stroke risk.

A study from the University of Colorado suggests erythritol may damage cells in the blood-brain barrier, the brain’s security system that keeps out harmful substances while letting in nutrients.

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