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Category: biotech/medical – Page 428

A long-term analysis conducted by leading microbiologists at the Icahn School of Medicine at Mount Sinai reveals that antibody responses induced by COVID-19 vaccines are long-lasting. The study results, published online in the journal Immunity challenge the idea that mRNA-based vaccine immunity wanes quickly.

The emergence of SARS-CoV-2, the virus that causes COVID-19, in late 2019 sparked the global pandemic that is now in its fifth year. Vaccines that were developed at record speed have saved millions of lives. However, the emergence of SARS-CoV-2 variants and waning immunity have decreased the effectiveness of the vaccines against symptomatic disease. The common perception now is that mRNA-based vaccine-induced immunity wanes quickly.

However, this assumption is largely based on data from short-term studies that include a very limited number of data points following peak responses.

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Science: In future maybe wounds be cured and closed in seconds by 3D printing regeneration.

Fat tissue holds the key to 3D printing layered living skin and potentially hair follicles, according to researchers who recently harnessed fat cells and supporting structures from clinically procured human tissue to precisely correct injuries in rats. The advancement could have implications for reconstructive facial surgery and even hair growth treatments for humans.

The team’s findings were published March 1 in Bioactive Materials. The U.S. Patent and Trademark Office granted the team a patent in February for the bioprinting technology it developed and used in this study.

“Reconstructive surgery to correct trauma to the face or head from injury or disease is usually imperfect, resulting in scarring or permanent hair loss,” said Ibrahim T. Ozbolat, professor of engineering science and mechanics, of and of neurosurgery at Penn State, who led the that conducted the work.

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According to a Mayo Clinic study published in Nature Neuroscience, the cells that act as the central nervous system’s first line of defense against harm also play a role in helping the brain awaken from anesthesia. This discovery could help pave the way for innovative methods that address post-anesthesia complications.

When coming out of anesthesia, more than one-third of patients can experience either extreme drowsiness or hyperactivity, a side effect called delirium. Mayo researchers found that special immune cells in the brain called microglia can act to shield neurons from the aftereffects of anesthesia to awaken the brain.

“This is the first time we’ve seen microglia enhance and boost by physically engaging the brain circuits,” says Mayo Clinic neuroscientist Long-Jun Wu, senior author of the study.

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Artificial intelligence (AI) has the potential to transform technologies as diverse as solar panels, in-body medical sensors and self-driving vehicles. But these applications are already pushing today’s computers to their limits when it comes to speed, memory size and energy use.

Fortunately, scientists in the fields of AI, computing and nanoscience are working to overcome these challenges, and they are using their brains as their models.

That is because the circuits, or neurons, in the have a key advantage over today’s computer circuits: they can store information and process it in the same place. This makes them exceptionally fast and energy efficient. That is why scientists are now exploring how to use materials measured in billionths of a meter— nanomaterials—to construct circuits that work like our neurons. To do so successfully, however, scientists must understand precisely what is happening within these nanomaterial circuits at the atomic level.

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Plant genomics has come a long way since Cold Spring Harbor Laboratory (CSHL) helped sequence the first plant genome. But engineering the perfect crop is still, in many ways, a game of chance. Making the same DNA mutation in two different plants doesn’t always give us the crop traits we want. The question is why not? CSHL plant biologists just dug up a reason.

CSHL Professor and HHMI Investigator Zachary Lippman and his team discovered that tomato and Arabidopsis thaliana plants can use very different regulatory systems to control the same exact gene. Incredibly, they linked this behavior to extreme genetic makeovers that occurred over 125 million years of evolution.

The scientists used genome editing to create over 70 mutant strains of tomato and Arabidopsis thaliana plants. Each mutation deleted a piece of regulatory DNA around a gene known as CLV3. They then analyzed the effect each mutation had on and development. When the DNA keeping CLV3 in check was mutated too much, fruit growth exploded. They published their findings in PLoS Genetics.

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Paclitaxel is the world’s best-selling plant-based anticancer drug and one of the most effective anticancer drugs over the past 30 years. It is widely used in the treatment of various types of cancer, including breast cancer, lung cancer, and ovarian cancer.

In the late 1990s and early 21st century, the annual sales of paclitaxel exceeded $1.5 billion and reached $2.0 billion in 2001, making it the best-selling drug in 2001. In 2019, the market for paclitaxel and its derivatives was approximately $15 billion, and it is expected to reach $20 billion by 2025.

As an anticancer drug, the molecular structure of paclitaxel is extremely complex, with highly oxidized, intricate bridged rings and 11 stereocenters, making it widely recognized as one of the most challenging natural products to synthesize chemically. Since the first total synthesis of paclitaxel was reported by the Holton and Nicolaou research groups in 1994, more than 40 research teams have been engaged in the total synthesis of paclitaxel.

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New research has identified iron deficiencies in the blood as a major culprit in long COVID cases.

A new report from the University of Cambridge was able to connect that low iron levels contributed to inflammation and anemia and halted healthy red blood cell production in patients just two weeks after being diagnosed with COVID-19.

Many of those individuals reported having long COVID — which has recently been associated with a frightening IQ loss from brain fog — within months, according to the study, published in Nature Immunology.

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A pair of chemists at the University of Groningen in the Netherlands, has observed communication between rotors in a molecular motor. In their study, reported in the Journal of the American Chemical Society, Carlijn van Beek and Ben Feringa conducted experiments with alkene-based molecular motors.

Molecular motors are natural or artificial molecular machines that convert energy into movement in living organisms. One example would be DNA polymerase turning single-stranded DNA into double-stranded DNA. In this new effort, the researchers were experimenting with light-driven, alkene-based molecular motors, using light to drive molecular rotors. As part of their experiments, they created a motor comprising three gears and two rotors and observed an instance of communication between two of the rotors.

To build their motor, the researchers started with parts of existing two motors, bridging them together. The resulting isoindigo structure, they found, added another dimension to their motor relative to other synthesized motors—theirs had a doubled, metastable intermediary connecting two of the rotors, allowing for communication between the two.

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Study shows #Glucagon is #Key for #Kidney #Health.

When researchers removed receptors for this hormone (best known for promoting blood sugar production in the liver) from mouse kidneys, the animals developed symptoms akin to chronic kidney disease…

Glucagon, a hormone best known for promoting blood sugar production in the liver, also appears to play a key role in maintaining kidney health. When UT Southwestern Medical Center researchers removed receptors for this hormone from mouse kidneys, the animals developed symptoms akin to chronic kidney disease (CKD).

Their findings, published in Cell Metabolism, shed new light on glucagon’s physiological functions and provide new insights into CKD, a disease that affects hundreds of millions of people around the globe, according to the National Institute of Diabetes and Digestive and Kidney Diseases.

“Our study defines important protective effects of glucagon for kidney health and normal systemic metabolic well-being of the entire organism,” said study leader Philipp Scherer, Ph.D., Professor of Internal Medicine and Cell Biology and Director of UTSW’s Touchstone Center for Diabetes Research.

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A recent study conducted at Tel Aviv University has devised a large mechanical system that operates under dynamical rules akin to those found in quantum systems. The dynamics of quantum systems, composed of microscopic particles like atoms or electrons, are notoriously difficult, if not impossible, to observe directly.

However, this new system allows researchers to visualize occurring in specialized “topological” materials through the movement of a system of coupled pendula.

The research is a collaboration between Dr. Izhar Neder of the Soreq Nuclear Research Center, Chaviva Sirote-Katz of the Department of Biomedical Engineering, Dr. Meital Geva and Prof. Yair Shokef of the School of Mechanical Engineering, and Prof. Yoav Lahini and Prof. Roni Ilan of the School of Physics and Astronomy at Tel Aviv University and was recently published in the Proceedings of the National Academy of Sciences.

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