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Category: biotech/medical – Page 399

PlasmaBlade-assisted surgical septal myectomy: technique and our experience

The pulsed-electron avalanche knife (PEAK) PlasmaBlade is an electrosurgical device that provides atraumatic, scalpel-like cutting precision and electrocautery-like hemostasis. Primarily, the PlasmaBlade uses pulsed radiofrequency energy to generate a plasma-mediated discharge along the exposed rim of an insulated blade. Plasma is an electrically conductive cloud created when the energy contacts tissue. The “plasma” allows the radiofrequency energy to cross the tissue at a much lower overall power level, resulting in lower operating temperatures and less thermal damage (7). The PlasmaBlade operates at 40–100°C, while the blade tip stays near body temperature. Therefore, underlying tissue damage is limited. Studies reporting the use of the PlasmaBlade during internal mammary artery harvesting or ocular surgeries have found the area of collateral damage to be only 2–10 μm with the PlasmaBlade compared to 100–400 μm with electrosurgery (7, 8).

The PlasmaBlade has been extensively used in ophthalmologic, plastic, and dermatological surgeries as precisely as a scalpel with the hemostatic control of conventional electrosurgery. Studies have also reported a reduced risk of bleeding, tissue injury, and scar formation with the PlasmaBlade (9– 11). However, experience in cardiac surgery is limited to pocket creation for the pacemaker and implantable cardioverter defibrillator (ICD) implantation (12, 13) and internal mammary artery harvesting (7).

In our institute, we have used the PlasmaBlade to perform SSM for the last 4 years. The purpose of this retrospective study is to review our clinical outcomes and the effect of PlasmaBlade cutting on the excised muscle in terms of necrosis and inflammation.

Generative AI models build new antibiotics starting from a single atom

Researchers have tapped into the power of generative artificial intelligence to aid them in the fight against one of humanity’s most pernicious foes: antibiotic-resistant bacteria. | Researchers have tapped into the power of generative artificial intelligence to aid them in the fight against one of humanity’s most pernicious foes: antibiotic-resistant bacteria. Using a model trained on a library of about 40,000 chemicals, scientists were able to build never-before-seen antibiotics that killed two of the most notorious multidrug-resistant bacteria on earth.

Gut Neurons Direct Immune Healing After Inflammation

Their previous work revealed that ILC2s are a major source of a tissue-healing growth factor called amphiregulin and have the capacity to receive neuronal signals that modulate their function and can impact disease progression and recovery.

In the new study, they demonstrated that the tissue-protective function of ILC2s depends on production of a molecule called adrenomedullin 2 (ADM2) from the enteric nervous system; administering the molecule expanded this group of ILC2s and provided therapeutic benefit in a preclinical model of inflammatory bowel disease, whereas loss of ADM2 signaling exacerbated disease due to the lack of these protective cells.

Engineers Take a Closer Look at How a Plant Virus Primes the Immune System to Fight Cancer

A virus that typically infects black-eyed peas is showing great promise as a low-cost, potent cancer immunotherapy—and researchers are uncovering why.

In a study published in Cell Biomaterials, a team led by chemical and nano engineers at the University of California San Diego took a closer look at how the cowpea mosaic virus (CPMV), unlike other plant viruses, is uniquely effective at activating the body’s immune system to recognize and attack cancer cells.

In preclinical studies, CPMV has demonstrated potent anti-tumor effects in multiple mouse models, as well as in canine cancer patients. When injected directly into tumors, CPMV therapy recruits innate immune cells—such as neutrophils, macrophages and natural killer cells—into the tumor microenvironment to destroy cancer cells. Meanwhile, it activates B cells and T cells to establish systemic, long-lasting anti-tumor memory. This immune reawakening not only helps clear the targeted tumor but also primes the immune system to hunt down metastatic tumors elsewhere in the body.

Unique fingerprints in 3D printing may foil adversaries

3D printing is a simple way to create custom tools, replacement pieces and other helpful objects, but it is also being used to create untraceable firearms, such as ghost guns, like the one implicated in the late 2024 killing of UnitedHealthcare CEO Brian Thompson.

Netanel Raviv, assistant professor of computer science & engineering in the McKelvey School of Engineering at Washington University in St. Louis, led a team from the departments of Computer Science & Engineering and Biomedical Engineering that has developed a way to create an embedded fingerprint in 3D-printed parts that would withstand the item being broken, allowing authorities to gain information for forensic investigation, such as the identity of the printer or the person who owns it and the time and place of printing.

The research will be presented at the USENIX Security Symposium Aug. 13–15, 2025, in Seattle. The first authors of the paper are Canran Wang and Jinweng Wang, who earned doctorates in computer science in 2024 and 2025, respectively. The research is published on the arXiv preprint server.

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