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Archive for the ‘biotech/medical’ category: Page 400

Nov 15, 2023

Gene Variant Linked to New Forms of Early-Onset Dystonia, Parkinsonism

Posted by in categories: biotech/medical, neuroscience

Scientists from Centogene, a company focused on rare and neurodegenerative diseases, along with their collaborators at University College London and elsewhere have published a study that links the Acyl-CoA Binding Domain Containing 6 (ACBD6) gene to new forms of early-onset dystonia and parkinsonism. The study is published in Brain in a paper titled, “Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders.”

Using whole exome sequencing data from 45 patients—23 males and 22 females between the ages of 1 and 50 years old—the researchers identified several novel and ultra-rare bi-allelic predicted loss-of-function variants in ACBD6, which are linked to a unique neurodevelopmental syndrome. The condition is accompanied by complex and progressive cognitive and movement disorders such as dystonia in 94% of cases and parkinsonism in older patients or about 32% of cases.

To test the association between ACBD6 and the syndrome, the researchers used zebrafish and frog knockouts. According to tests described in the paper, they observed similar phenotypes to those of affected individuals such as movement disorders, seizures, and facial dysmorphology in the zebrafish models. Their observations of the effects in zebrafish suggest “a combination of muscle and neuronal degeneration leading to movement abnormalities” resulting from the loss of the gene. When they assessed the effects of inactivating the gene in frogs, they observed reported failures in cell movement during gastrulation as a result of the gene’s loss.

Nov 15, 2023

Scientists have discovered what may be the first ‘vampire’ virus

Posted by in category: biotech/medical

Scientists discovered a strange virus called MiniFlayer that latches onto a larger virus called MindFlayer in soil collected in Maryland.

Nov 15, 2023

Drug-Activated Protein Boosts Memory

Posted by in categories: bioengineering, biotech/medical, chemistry, genetics, life extension, neuroscience

Summary: Researchers made a breakthrough in memory research by genetically modifying the LIMK1 protein, crucial for memory, to be controlled by the drug rapamycin.

This study demonstrates the ability to enhance memory functions by manipulating synaptic plasticity in the brain.

The engineered protein showed significant memory improvement in animal models with age-related cognitive decline, offering potential for innovative treatments for neuropsychiatric diseases like dementia. This ‘chemogenetic’ approach, blending genetics and chemistry, opens new avenues in neurological research and therapy.

Nov 15, 2023

Slow Wave Sleep % Loss Is Associated With An Increased Dementia Risk

Posted by in categories: biotech/medical, genetics, life extension, neuroscience

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Continue reading “Slow Wave Sleep % Loss Is Associated With An Increased Dementia Risk” »

Nov 15, 2023

New study identifies 4,749 key gene clusters that influence progression of 32 cancer types

Posted by in categories: biotech/medical, genetics

Researchers at the Mount Sinai Center for Transformative Disease Modeling have released a groundbreaking study identifying 4,749 key gene clusters, termed “prognostic modules,” that significantly influence the progression of 32 different types of cancer. The study, published in Genome Research, serves as a comprehensive resource and lays the foundation for the development of next-generation cancer treatments and diagnostic markers.

Despite significant progress in cancer research, understanding the disease’s genetic intricacies remains challenging. Previous research often focused on isolated gene functions in specific cancer types.

We aimed to fill this knowledge gap by providing a comprehensive analysis of gene-gene interactions across various forms of cancer.

Nov 15, 2023

Scientists debunk notions of optogenetics controlling the human brain

Posted by in categories: biotech/medical, genetics, robotics/AI

In an exclusive interview, Peter Hegemann said AI is more dangerous than optogenetics.


Contrary to popular belief, there is very little chance that optogenetics will be used in the future to control the human brain, says Peter Hegemann, a biochemist and biophysicist, in a conversation with Interesting Engineering (IE) at the Hong Kong Laureate Forum 2023.

Optogenetics is a scientific technique that uses light to control and manipulate cells within living tissues, particularly in the brain. It allows researchers to control the activity of specific neurons with high precision, both in terms of location and timing.

Continue reading “Scientists debunk notions of optogenetics controlling the human brain” »

Nov 15, 2023

Forward Health launches CarePods, a self-contained, AI-powered doctor’s office

Posted by in categories: biotech/medical, health, information science

Get a blood test, check blood pressure, and swab for aliments — all without a doctor or nurse.

Adrian Aoun, CEO and co-founder of Forward Health, aims to scale healthcare.


Adrian Aoun, CEO and co-founder of Forward Health, aims to scale healthcare. It started in 2017 with the launch of tech-forward doctor’s offices that eschewed traditional medical staffing for technology solutions like body scanners, smart sensors, and algorithms that can diagnose ailments. Now, in 2023, he’s still on the same mission and rolled up all the learnings and technology found in the doctor’s office into a self-contained, standalone medical station called the CarePod.

Continue reading “Forward Health launches CarePods, a self-contained, AI-powered doctor’s office” »

Nov 15, 2023

Should You Consider Lung Cancer Screening?

Posted by in category: biotech/medical

Annual low-dose CT lung cancer screening is recommended based on age and smoking history. Find out if you are eligible.

Nov 15, 2023

Antibiotics: Used properly, antibiotics can save lives by fighting bacterial infections

Posted by in category: biotech/medical

Read about how to use antibiotics and about when not to use antibiotics.

Nov 15, 2023

Scientists Just Recreated The Chemical Reaction That May Have Led to Life on Earth

Posted by in categories: biotech/medical, chemistry

How did life begin? How did chemical reactions on the early Earth create complex, self-replicating structures that developed into living things as we know them?

According to one school of thought, before the current era of DNA-based life, there was a kind of molecule called RNA (or ribonucleic acid). RNA – which is still a crucial component of life today – can replicate itself and catalyse other chemical reactions.

But RNA molecules themselves are made from smaller components called ribonucleotides. How would these building blocks have formed on the early Earth, and then combined into RNA?

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