This study examined whether periventricular white matter hyperintensities relate to region-specific cortical hypometabolism and metabolism mediates domain-specific cognition in Aβ-negative individuals.
Letters to the Editor.
The Letters section represents an opportunity for ongoing author debate and post-publication peer review. View our submission guidelines for Letters to the Editor before submitting your comment.
Today’s episode on Redefining Medicine features Ronald Klatz, MD, DO. As Founder and President of the American Academy of Anti-Aging Medicine, and leading authority in the field of anti-aging, Dr. Klatz has helped pioneer the exploration of new therapies and treatments for the prevention of chronic disease, and other disorders associated with aging. Dr. Klatz has also been instrumental in founding the National Academy of Sports Medicine, and continues to provide oversight for continuing medical education programs, activities, and publications. #antiaging #regenerativemedicine #wellness #sportsmedicine #Innovation #wellness #functionalmedicine
Meet the biotech startups brewing milk in bioreactors to improve on baby formula.
Background and ObjectivesChronic immune activation is a hallmark of latent viral infections and autoimmune disorders, profoundly shaping immune cell phenotypes, including CD4+ cytotoxic T lymphocytes (CD4 CTL). The mechanisms underlying CD4 CTL…
St. Jude Children’s Research Hospital scientists have discovered how tumors disable immune “gatekeeper” cells that alert the rest of the immune system to the presence of cancer—and how restoring their energy production can improve immunotherapy. Dendritic cells activate the cytotoxic immune cells that destroy cancer. The researchers found that tumors reduce dendritic cell function by decreasing their mitochondrial fitness, thus preventing formation of the anticancer immune response.
The results, published in Science, also show that boosting mitochondrial function in dendritic cells enhances antitumor immune activity and strengthens the efficacy of existing immunotherapies.
Dendritic cells alert and activate tumor-killing immune cells as a critical part of anticancer immune response. However, within the nutrient-sparse tumor microenvironment (the complex mixture of chemicals, cells and other factors near cancer cells), dendritic cells progressively lose their energy-producing mitochondrial activity. That loss drives dendritic cell dysfunction and weakens the body’s immune defenses against cancer.
Teen girls born with a rare genetic disorder are functioning well years after successful organ implant surgeries
A promising cancer therapy, targeting infected tumors, is set for its first human trials as soon as May/June. This innovative approach shows potential for various solid cancers and could significantly impact treatment timelines, offering hope particularly for pancreatic cancer patients.
You’ve seen people sliding into the tube of a magnetic resonance imaging (MRI) machine on your favorite medical drama, or maybe you’ve been inside one yourself, waiting as the noisy scanner makes images of your brain, heart, bones, or other structures, which doctors use to identify injury or disease.
Since the 1970s, MRIs have been important diagnostic tools, combining a magnetic field and radio waves to produce snapshots of the body’s interior without using ionizing radiation, which can create health risks at higher doses. An MRI can typically capture changes in anatomy, but the molecular-level changes that could further aid understanding of disease have been beyond its reach.
Now, in a new article in Science Advances, University of California, Santa Barbara researchers report the invention of a modular, genetically encoded, protein-based sensor that enables MRI machines to visualize molecular activity inside cells—a development that could transform how scientists study cancer, neurodegeneration, and inflammation.
Hidden within fish DNA are powerful genetic twists that may explain one of nature’s biggest mysteries: how new species form so quickly. In Lake Malawi, hundreds of cichlid fish species evolved at lightning speed, and scientists now think “flipped” sections of DNA—called chromosomal inversions—are the secret. These inversions lock together useful gene combinations, creating “supergenes” that help fish rapidly adapt to different environments, from deep waters to sandy shores.
Superconductivity—the ability of a material to conduct electricity without any energy loss to heat—enables highly efficient, ultra-fast electronics essential for advanced technologies such as magnetic resonance imaging (MRI) machines, particle accelerators and, potentially, quantum computers. New research has now revealed that iron telluride (FeTe), a compound composed of the chemical elements iron and tellurium and long thought to be an ordinary magnetic metal, is in fact a superconductor. The researchers found that hidden excess iron atoms induce the material’s magnetism, and removing these atoms allows electricity to flow with zero resistance.
Two papers describing the research, both led by Penn State Professor of Physics Cui-Zu Chang, were published back-to-back today (April 1) in the journal Nature. The first paper focuses on how to “switch on” superconductivity in FeTe, while the second paper reveals a new kind of “quantum dance,” where superconductivity interacts with the material’s atomic structure when a different top layer is added, allowing researchers to tune its behavior.
“Unlike the well-known iron-based superconductor iron selenide (FeSe), FeTe has long been considered a magnetic metal without superconductivity, despite having an almost identical crystal structure,” Chang said. “It has remained a mystery why FeTe doesn’t share this important property.”
