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Wooden Neurons: An Artistic Vision of the Brain

For Louis-Jan Pilaz, days spent with tools and wood began as simple home improvement projects. He soon found himself learning how to whittle scraps of wood. Then, as a neurobiologist, Pilaz noticed a striking parallel. “It made so much sense to use wood to render neurons…They look like trees, and they have this flow of energy that is just like in neurons.” Inspired, he began to shape wood into intricate neural forms, transforming casual whittling into science-inspired woodworking art.

When he first shared his artwork on X (then Twitter), the response was positive, and people expressed their interest in his work. Encouraged by his graduate student, Pilaz opened an Etsy shop in 2021 to sell his wood sculptures, and NeuroWoodworks was born.

Pilaz’s group at Sanford Research studies the development and dysfunction of the cerebral cortex and makes extensive use of microscopy, which fuels his research and serves as a source of inspiration for his wood art. “I’ve been obsessed with cell morphology since my PhD,” Pilaz said. “I experimented, just like I do in the lab, with the tools I have and tried to make [different cell] shapes.” He uses different types of wood, such as walnut and padauk, to create a variety of cell types and structures from Purkinje cells and radial glia to mitochondria.

New study suggests a way to rejuvenate the immune system

As people age, their immune systems decline. But a new study suggests a way to rejuvenate immune function: Stimulating the liver to produce some signals ordinarily generated by the thymus can reverse age-related declines in T-cell populations.


MIT and Broad Institute researchers found a way to overcome age-related immune system decline by temporarily programming liver cells to take over the maturation of T cells. Using mRNA, the researchers were able to rejuvenate the immune system, in a study of mice.

Thrombolysis With Tenecteplase for Minor Disabling Stroke: Secondary Analysis of the TEMPO-2 Randomized Clinical Trial

A secondary analysis of the TEMPO-2 RCT found no significant improvement in outcomes for minor ischemic stroke patients treated with intravenous tenecteplase, regardless of the presence of disabling deficits.


Question Did outcomes following intravenous tenecteplase for minor ischemic stroke vary based on the presence of disabling deficits?

Findings In this secondary analysis of the TEMPO-2 randomized clinical trial including 884 patients with minor ischemic stroke and proven intracranial occlusion, both patients with and without disabling deficits defined according to US National Institutes of Health Stroke Scale (NIHSS)–based criteria showed a neutral treatment effect from intravenous tenecteplase, with no significant effect modification.

Meaning Current definitions of disabling stroke did not modify the neutral treatment effect of intravenous tenecteplase in patients with minor stroke and intracranial occlusion.

A deep metagenomic atlas of Qinghai-Xizang Plateau lakes reveals their microbial diversity and salinity adaptation mechanisms

Zhang et al. construct a comprehensive microbial genome catalog from the Qinghai-Xizang Plateau lakes, with 80.78% of genomes representing previously undescribed taxa. Their research provides not only a holistic genomic resource for bioprospecting, but also suggests key salinity adaptation strategies, particularly the dominant role of glycine betaine uptake in hypersaline environments.

A vision of chromosome organization

The DNA of eukaryotic organisms is packaged by histone proteins into chromatin. The structural organization of chromatin is tied to its function. Loosely packed, more transcriptionally active regions of chromatin are known as euchromatin, whereas highly condensed, less transcriptionally active regions are known as heterochromatin.

Despite advances in the study of chromatin structure over the past 100 years, a biochemical understanding of how basic structural motifs beget higher-order chromatin organization remains lacking.

In a new Science study, researchers present an approach that enables imaging and analysis of the structure of chromatin condensates in situ, which moves the field much closer toward defining the structural chromatin motifs that underpin its nuclear functions.

Learn more in a new Science Perspective.


Cryogenic electron tomography of condensed chromatin enables multiscale analysis of its structure.

Kaite Zhang and Vijay Ramani Authors Info & Affiliations

Abstract: A widely held hypothesis posits that ER stress drives cell death in thyroid disease

Here, Peter Arvan & team generate a mouse model lacking thyroglobulin, finding stimulated thyroid hormone synthesis machinery drives thyrocyte cell death independent of ER stress:

The figure shows limited ER diameter in thyroid tissue from Tg-KO untreated mice.


Address correspondence to: Peter Arvan, Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Brehm Tower rm 5,112, 1000 Wall Street, Ann Arbor, Michigan 48,105, USA. Phone: 734.936.5505; Email: [email protected].

Molecular basis of vesicular monoamine transport and neurological drug interactions

Ye et al. reveal how VMAT2 loads monoamine neurotransmitters into storage vesicles and interacts with neurological drugs, facilitated by the structural flexibility of the transporter. Amphetamine directly triggers monoamine release to induce psychostimulation, likely by bypassing the regular transport cycle. These insights elucidate psychostimulant action and inform therapeutic strategies.

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