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Some doctors increasingly using artificial intelligence to take notes during appointments

It was easy to miss Dr. Robert Gray’s quick movements, tapping the screen of his smartphone at the beginning and end of patient visits on a recent day.

But Gray said those fast finger taps have changed his life. He was tapping an app that records discussions during his appointments and then uses to find the relevant information, summarize it and zap it, within seconds, into each patient’s electronic medical record.

The technology was meticulously documenting each visit so Gray didn’t have to.

Timely TGFβ signalling inhibition induces notochord

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The work, published today in Nature, marks a significant step forward in our ability to study how the human body takes shape during early development.

The notochord, a rod-shaped tissue, is a crucial part of the scaffold of the developing body. It is a defining feature of all animals with backbones and plays a critical role in organising the tissue in the developing embryo.

Despite its importance, the complexity of the structure has meant it has been missing in previous lab-grown models of human trunk development.

In this research, the scientists first analysed chicken embryos to understand exactly how the notochord forms naturally. By comparing this with existing published information from mouse and monkey embryos, they established the timing and sequence of the molecular signals needed to create notochord tissue.

With this blueprint, they produced a precise sequence of chemical signals and used this to coax human stem cells into forming a notochord.

The stem cells formed a miniature ‘trunk-like’ structure, which spontaneously elongated to 1–2 millimetres in length. It contained developing neural tissue and bone stem cells, arranged in a pattern that mirrors development in human embryos. This suggested that the notochord was encouraging cells to become the right type of tissue at the right place at the right time.

Study Reveals Key Alzheimer’s Pathway — And Blocking It Reverses Symptoms in Mice

A sequence of stress signals among specialized clean-up cells in the brain could at last reveal why some immune responses can cause significant nerve degeneration that results in the loss of memory, judgement, and awareness behind Alzheimer’s disease.

Blocking this pathway in mouse brains modeled on Alzheimer’s prevented damage to their synapse connections and reduced the buildup of potentially toxic tau proteins – both hallmarks of the condition.

The researchers, led by a team from the City University of New York (CUNY), believe this pathway – called the integrated stress response (ISR) – causes brain immune cells called microglia to go ‘dark’ and start damaging rather than benefiting the brain.

Scientists develop vaccine test that predicts how long immunity lasts

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A blood test that can predict how long vaccine immunity will last so people can get a booster jab earlier, is being developed by scientists.

Researchers have previously been unable to predict why some vaccines produce antibodies to fight infections that last for decades while in others immunity only lasts a few months.

Now Stanford University has found tell-tale signs in the blood in the days after vaccination to indicate how quickly a person’s antibody protection will wane.

Light-Switching Nanocrystals Ignite the Future of AI and Computing

Researchers have discovered nanocrystals that toggle between luminescent states swiftly, offering a promising advancement toward optical computing.

This technology could revolutionize data processing and artificial intelligence, making devices faster and more energy-efficient while expanding capabilities in telecommunications and medical imaging.

Breakthrough in Nanocrystal Technology.

Plastic crystals could replace greenhouse gases used in refrigerators

A new study from Vanderbilt University Medical Center shows that clinical alerts driven by artificial intelligence (AI) can help doctors identify patients at risk for suicide, potentially improving prevention efforts in routine medical settings.

A team led by Colin Walsh, MD, MA, associate professor of Biomedical Informatics, Medicine and Psychiatry, tested whether their AI system, called the Vanderbilt Suicide Attempt and Ideation Likelihood model (VSAIL), could effectively prompt doctors in three neurology clinics at VUMC to screen patients for suicide risk during regular clinic visits.

The study, reported in JAMA Network Open, compared two approaches—automatic pop-up alerts that interrupted the doctor’s workflow versus a more passive system that simply displayed risk information in the patient’s electronic chart.

WHO declares Mpox global health emergency

The World Health Organization (WHO) has declared the mpox outbreak in parts of Africa a public health emergency of international concern.

The highly contagious disease — formerly known as monkeypox — has killed at least 450 people during an initial outbreak in the Democratic Republic of Congo.

It has now spread across parts of central and east Africa, and scientists are concerned about how fast a new variant of the disease is spreading and its high fatality rate.