Lifeboat Foundation

From Alzheimer’s discoveries to animal organ transplants, new breakthroughs are improving and extending lives.

In a new Nature Communications study, researchers have explored the construction of genetic circuits on single DNA molecules, demonstrating localized protein synthesis as a guiding principle for dissipative nanodevices, offering insights into artificial cell design and nanobiotechnology applications.

The term “genetic circuit” is a metaphorical description of the complex network of genetic elements (such as genes, promoters, and regulatory proteins) within a cell that interact to control gene expression and cellular functions.

In the realm of artificial cell design, scientists aim to replicate and engineer these genetic circuits to create functional, self-contained units. These circuits act as the molecular machinery responsible for orchestrating cellular processes by precisely regulating the production of proteins and other molecules.

— Anti-aging vaccine shows promise in mice — will it work in humans?

“This research is still in the early stages and may be a number of years from being available to patients,” Dr. David Pinato, a clinician scientist at Imperial College London’s Department of Surgery & Cancer and a consultant medical oncologist at Imperial College Healthcare NHS Trust, said in the statement. “But this trial is laying crucial groundwork that is moving us closer towards new therapies that are potentially less toxic and more precise.”

The first person treated in the U.K. arm of the trial wishes to remain anonymous, but said “I was pleased to be offered a chance to take part in a new trial.”

Could cannabis use lead to anxiety disorders? This is what a recent study published in EClinicalMedicine hopes to address as a team of researchers led by the Ottawa Hospital Research Institute examine the connection between cannabis use and anxiety disorders by patients who have had emergency department visits. While this study was limited to Canada, it holds the potential to help researchers, legislators, and the public better understand the long-term risks of cannabis on mental health disorders throughout the world.

For the study, the researchers analyzed health records from 2008 to 2019 for 12,099,144 individuals between 10 and 105 years of age across Ontario, Canada who had no prior history of being diagnosed with an anxiety disorder from any hospital visit and compared this to the general population. In the end, the researchers found that 27.5 percent of individuals who visited a hospital for cannabis use were diagnosed with an anxiety disorder within three years of their hospital visit, whereas only 5.6 percent of the general population experienced the same. Additionally, they found that individuals who visited a hospital for cannabis use also visited a hospital for an anxiety disorder within three years of the initial hospital visit, whereas only 1.2 percent of the general population experienced the same.

“Our results suggest that individuals requiring emergency department treatment for cannabis use were both at substantially increased risk of developing a new anxiety disorder and experiencing worsening symptoms for already existing anxiety disorders,” said Dr. Daniel Myran, who is a Faculty of Medicine in the Department of Family Medicine at the University of Ottawa and lead author of the study.

C. auris, a type of yeast that can cause severe illness, is a “global health threat”, according to experts.

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Mage: SonoCloud uses the therapeutic potential of pulsed ultrasound to temporarily disrupt the blood-brain barrier (Photo courtesy of Carthera) The blood-brain barrier (BBB) presents a significant…

Massachusetts startup Elemind has raised $12 million to read brainwaves and treat people for sleep disorders, long-term pain, tremors, and to speed up learning rates. Clinical trials show the company’s wearable device can accelerate sleep up to 70% faster, reduce tremors in patients with physiological shaking up to 50%, and boost learning rates.

“We use a wearable neurotech device to read the brain in real time and intercept it in real time with something called neurostimulation,” Elemind co-founder and CEO Meredith Perry told me on a recent TechFirst podcast. “That’s using sound or light or vibration or electricity to stimulate the brain. And when we do that, we can actually guide the brain precisely, and that leads to a behavior change. So like a drug, but much smarter and without the side effects.”

While combing through the human genome in 2007, computational geneticist Pardis Sabeti made a discovery that would transform her research career. As a then-postdoctoral fellow at the Broad Institute of MIT and Harvard, Sabeti discovered potential evidence that some unknown mutation in a gene called LARGE1 had a beneficial effect in the Nigerian population.

Other scientists had discovered that this gene was critical for the Lassa virus to enter cells. Sabeti wondered whether a mutation in LARGE1 might prevent Lassa fever—an infection that is caused by the Lassa virus, is endemic in West Africa, and can be deadly in some people while only mild in others.

To find out, Sabeti decided later in 2007, as a new faculty member at Harvard University, that one of the first projects her new lab at the Broad would take on would be a genome-wide association study (GWAS) of Lassa susceptibility. She reached out to her collaborator Christian Happi, now the Director of the African Center of Excellence for Genomics of Infectious Diseases (ACEGID) at Redeemer’s University in Nigeria, and together they launched the study.

In the future, modern machines should not only follow algorithms quickly and precisely, but also function intelligently—in other words, in a way that resembles the human brain. Scientists from Dortmund, Loughborough, Kiev and Nottingham have now developed a concept inspired by eyesight that could make future artificial intelligence much more compact and efficient.

They built an on-chip phonon-magnon reservoir for neuromorphic computing which has recently been featured as Editor’s Highlight by Nature Communications.

The human sensory organs convert information such as light or scent into a signal that the brain processes through myriads of neurons connected by even more synapses. The ability of the brain to train, namely transform synapses, combined with the neurons’ huge number, allows humans to process very complex external signals and quickly form a response to them.