Researchers from University of Jyväskylä and Aalto University in Finland have developed a customized DNA nanostructure that can perform a predefined task in human body-like conditions. To do so, the team built a capsule-like carrier that opens and closes according to the pH level of the surrounding solution. The nanocapsule can be loaded—or packed—with a variety of cargo, closed for delivery and opened again through a subtle pH increase.
The findings, published in the journal Nature Medicine, showcase a novel CRISPR/Cas9 genome-editing therapy that can suppress the accelerated aging observed in mice with Hutchinson-Gilford progeria syndrome. This treatment provides an important insight into the molecular pathways involved in accelerated aging, as well as how to reduce toxic proteins via gene therapy. The researchers hope to translate this therapy to humans to potentially provide a cure for progeria as well as possibly slowing down the aging process to delay the onset of age-related diseases in everyone.
Link to paper: https://www.nature.com/articles/s41591-019-0343-4
Abstract.
Researchers have tested nicotinamide mononucleotide on aged mice to see if it can help reverse age-related cognitive decline by improving blood flow in the brain.
The brain is a hungry organ
Healthy brain function relies on efficient cerebral blood flow (CBF) to wash away harmful waste products for disposal and supply the brain with an adequate supply of oxygen and sufficient nutrients.
Drones might be a favorite toy among adults with significant disposable income, but they’ve also proven to be incredibly useful as tools, and sometimes life-saving ones at that. The latest example of this growing trend comes to us from the University of Maryland Medical Center, where a medical drone delivered a kidney that was subsequently successfully transplanted into a patient.
The delivery, which was documented in a brief YouTube video published by UMMC, is just a small first step in a larger effort to enhance the delivery systems used for vital items like organs and other medical materials.
The drone delivery of a kidney recently used for an organ transplant in Baltimore is being characterized by the University of Maryland as a “pioneering breakthrough” advancement in human medicine and aviation technology.
“It’s huge. We knew from the very first time that we met with Dr. (Joseph) Scalea, and he suggested the idea of what he wanted to do — we knew it would be earth-shattering and life-changing, and it really has become that,” Matthew Scassero, director of the Unmanned Aircraft Systems Test Site at the University of Maryland, told WTOP.
The unmanned aircraft system’s flight on April 19 through the city of Baltimore occurred at about 12:30 a.m. and was less than 3 miles, but represents a huge first step.
Smart watches. Pacemakers. Internet-connected glasses. These are devices designed to make life easier. And yet, all this wearable technology can be hacked. The devices send personal health information to your smartphone over the airways, so anyone with the know-how could scoop it up and steal it. But now, researchers at Northeastern have a better, more secure idea: Send data through your body.
Associate professor Kaushik Chowdhury worked with a team of researchers from the Draper Laboratory in Cambridge, Massachusetts, and the Federal University of Paraná in Brazil to develop a safe, hacker-proof method to transmit sensitive data.
“The truth is, no matter what I do when it comes to wireless devices, I’m radiating the signal through the air,” Chowdhury says. “There is the danger that the signal can be jammed, or analyzed by someone else. Our method secures this sensitive information so it can’t be leaked.”
You can live without food for three weeks and without water for up to three days. But you can’t live without air for more than three short minutes. It’s not just the abundance of air that matters – the quality is essential, too. Unfortunately, air can be contaminated with dangerous germs known as airborne pathogens, such as bacteria and viruses.
Airborne diseases are very easily transmitted, and can result in respiratory illness that can be life threatening. It’s therefore no wonder that outbreaks of airborne infectious diseases are a major public health concern, and that researchers are working hard to come up with technologies to provide clean air. So far, however, such technologies have had limited success.
Now a new study suggests that non-thermal plasma – a cool gas made up of electrically charged particles, despite having no overall charge – could inactivate airborne viruses and provide sterile air. Although the technology has a long history and many applications (in medicine and food industry), this is a completely new use for it.
Urine testing may be as effective as the smear test at preventing cervical cancer, according to new research by University of Manchester scientists.
The study, led by Dr. Emma Crosbie and published in BMJ Open, found that urine testing was just as good as the cervical smear at picking up high-risk human papillomavirus (HPV), the virus that causes cervical cancer.
The research team say a urine test could help increase the numbers of women who are screened for cervical cancer, which affects more than 3,000 women every year in the UK.
If the virus that causes flu were an ice cream cone, then the yearly vaccine teaches the immune system to recognize just the scoop – chocolate one year, strawberry the next. As the virus changes each year, so too must the vaccine.
A new approach that teaches the body to recognize the cone portion of the virus – which stays the same year-to-year – could shake up that yearly vaccination ritual and protect people against pandemic flu like the one that killed 40 to 50 million people in 1918. The team working on this new approach, led by Stanford biochemist Peter Kim, has shown early signs that their technique works in lab animals. They warn that they still need to make their vaccine more specific and show it works in much larger studies before testing it in people.
“We think it could be very generalizable,” said Kim, who is the Virginia and D.K. Ludwig professor of biochemistry and the lead investigator of the infectious disease initiative at the Chan Zuckerberg Biohub. “It could be important for coming up with a universal flu vaccine that would protect against pandemic flu, as well as for HIV.”