Live Science spoke with Šikšnys about what it’s been like to see CRISPR enter clinical use and how he thinks the system might be applied and improved upon in the future.
Editor’s Note: This interview has been condensed and edited for clarity.
Related: Gene therapy: What is it and how does it work?
CHICAGO, Feb 19 (Reuters) — A study that analyzed the genetic code of a quarter of a million U.S. volunteers found more than 275 million entirely new variants that may help explain why some groups are more prone to disease than others, researchers reported on Monday.
The whole genome sequencing data from a wide range of Americans aims to address the historical lack of diversity in existing genomic datasets by focusing on previously under-represented groups. The U.S. National Institutes of Health-funded “All of Us” study turned up 1 billion genetic variants in total.
“Sequencing diverse populations can lead to new drug targets that are relevant to everyone,” said Dr. Josh Denny, a study author and its chief executive. “It can also help uncover disparities that lead to specific treatments for people that are experiencing higher burdens of disease or different disease.”
This is all good but I really like the telomeres results.
Liz Parrish presents the stunning progress of gene therapies and how to collaborate to cure aging in this clip.
Continue reading “Living Longer, Living Better: Gene Therapy’s Stunning Progress For Longevity” »
A new study led by Stanford Medicine scientists demonstrates a simple way of studying organ aging by analyzing distinct proteins, or sets of them, in blood, enabling the prediction of individuals’ risk for diseases.
To synthesize potential drugs or natural products, you need natural substances in specific mirror-image variants and with a high degree of purity. For the first time, chemists at the University of Bonn have succeeded in producing all eight possible variants of polypropionate building blocks from a single starting material in a relatively straightforward process. Their work has now been published in Angewandte Chemie International Edition.
Polypropionates are natural products that can help save lives. They are needed to make reserve antibiotics, compounds that are only ever used to treat infections caused by drug-resistant bacteria. In nature, chiral compounds exist in two different variants that share the same molecular formula but are mirror images of each other, like a right and a left hand. Chemists call this “chirality,” which literally means “handedness.”
“What’s interesting is that the mirror-image forms can have very different properties,” explains Professor Andreas Gansäuer from the Kekulé Institute of Organic Chemistry and Biochemistry at the University of Bonn. “One well known example is undoubtedly carvone. The dextro-, or ‘right-handed,’ form of this molecule smells of caraway, while its levo-, or ‘left-handed,’ form is what gives peppermint its distinctive odor.”
AstraZeneca Plc shares rose after trial data showed Tagrisso slowed disease progression in patients with advanced lung cancer in another win for the pharmaceutical giant’s blockbuster drug.
Excess amounts of vitamin B3 — which is found in meat, fish, nuts, and fortified cereals and breads — may trigger inflammation and damage blood vessels.
Genetic Engineering and DNA alteration is an emerging technology with huge ramifications in the future, including potentially altering the DNA of adult humans, not just embryos or plants \& animals.
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Study uses AI and blood samples from 50,000 to predict dementia 15 years in advance, offering hope for early intervention.
A team of researchers in Spain has achieved a breakthrough by capturing the world’s first detailed images of a human cell’s ‘highway network’ beginning to emerge.
The high-resolution images and atomic-scale film help explain a longstanding puzzle of how small structures called microtubules form during cell division. The discovery could progress the development of targeted treatments for cancer, and many other conditions.
Continue reading “Scientists Unveil First-Ever Images of a Cell Building Its ‘Molecular Highway’” »
