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Category: biotech/medical – Page 254

New study shows ‘#Dancing #Molecules’ can #Regenerate #Cartilage in 3 days.

In the new study, the treatment activated gene expression needed to regenerate cartilage in just 4h. After 3 days, cells produced protein components for cartilage regeneration…

In November 2021, Northwestern University researchers introduced an injectable new therapy, which harnessed fast-moving “dancing molecules,” to repair tissues and reverse paralysis after severe spinal cord injuries.

Now, the same research group has applied the therapeutic strategy to damaged human cartilage cells. In the new study, the treatment activated the gene expression necessary to regenerate cartilage within just four hours. And, after only three days, the human cells produced protein components needed for cartilage regeneration.

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The pursuit of a cure for Alzheimer’s disease is becoming an increasingly competitive and contentious quest with recent years witnessing several important controversies.

In July 2022, Science magazine reported that a key 2006 research paper, published in the prestigious journal Nature, which identified a subtype of brain protein called beta-amyloid as the cause of Alzheimer’s, may have been based on fabricated data.

One year earlier, in June 2021, the US Food and Drug Administration had approved aducanumab, an antibody-targeting beta-amyloid, as a treatment for Alzheimer’s, even though the data supporting its use were incomplete and contradictory.

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ROCHESTER, Minn. — Mayo Clinic scientists are using artificial intelligence (AI) and machine learning to analyze electroencephalogram (EEG) tests more quickly and precisely, enabling neurologists to find early signs of dementia among data that typically go unexamined.

The century-old EEG, during which a dozen or more electrodes are stuck to the scalp to monitor brain activity, is often used to detect epilepsy. Its results are interpreted by neurologists and other experts trained to spot patterns among the test’s squiggly waves.

In new research published in Brain Communications, scientists at the Mayo Clinic Neurology AI Program (NAIP) demonstrate how AI can not only speed up analysis, but also alert experts reviewing the test results to abnormal patterns too subtle for humans to detect. The technology shows the potential to one day help doctors distinguish among causes of cognitive problems, such as Alzheimer’s disease and Lewy body dementia. The research suggests that EEGs, which are more widely available, less expensive and less invasive than other tests to capture brain health, could be a more accessible tool to help doctors catch cognitive issues in patients early.

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The Texas Heart Institute (THI) and BiVACOR®, a clinical-stage medical device company, announced today the successful first-in-human implantation of the BiVACOR Total Artificial Heart (TAH) as part of the U.S. Food and Drug Administration (FDA) Early Feasibility Study (EFS) on July 9, 2024.

BiVACOR’s TAH is a titanium-constructed biventricular rotary blood pump with a single moving part that utilizes a magnetically levitated rotor that pumps the blood and replaces both ventricles of a failing heart.

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Gut health has been making headlines for years, but its impact on heart health is only now unfolding. A new study from Cleveland Clinic and Tufts University researchers has uncovered a link between gut bacteria and heart health that could revolutionize cardiovascular care for seniors. This groundbreaking research suggests that the key to a healthy heart in our later years might be influenced by the microscopic inhabitants of our digestive system.

The study, published in Circulation: Heart Failure, followed nearly 12,000 initially healthy participants for almost 16 years. Researchers focused on the gut microbe called trimethylamine N-oxide (TMAO), which is produced when gut bacteria digest certain nutrients found in red meat and other animal products. The researchers discovered that elevated levels of TMAO in the blood were strongly associated with a higher risk of developing heart failure, even after accounting for other known risk factors.

Stanley Hazen, MD, PhD, chair of Cardiovascular and Metabolic Sciences in Cleveland Clinic’s Lerner Research Institute and the study’s senior author, emphasized the significance of these findings for predicting heart failure risk in seemingly healthy individuals. “Regular measurement of blood TMAO levels predicted incident risk for heart failure development during long-term follow-up,” he explained. This discovery opens new possibilities for early intervention and prevention strategies, particularly important for the elderly population who are at higher risk for heart-related issues.

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Not in leading research but interesting.

According to a new study, a polyphenol-rich natural extract positively impacts lifespan, healthspan, and cellular senescence. These results were observed in both cell culture and a mouse model [1].

Traditional and folk medicines offer many botanical extracts that can be tested by modern science for their medicinal properties and influences on aging. One such plant is the Bolivian prawn sage (Salvia haenkei).

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An ischemic stroke is a type of stroke that occurs when a blood clot in an artery, also known as thrombus, or the progressive narrowing of arteries, blocks the blood and oxygen flowing to the brain. This process can cause both temporary and permanent brain damage, for instance, leading to partial paralysis, cognitive impairments and other debilitating impairments.

Statistics suggest that older age increases the risk of experiencing ischemic strokes. While neuroscience studies have shed light on many of the physiological processes underpinning strokes, the immune responses following these events and promoting recovery remain poorly understood.

Researchers at the Institut Blood and Brain @ Caen-Normandie (BB@C), University of Edinburgh and other institutes in Europe carried out a study exploring how central nervous system (CNS)-associated macrophages (CAMs), immune cells residing at the CNS interfaces, contribute to post-stroke immune responses.

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