The brings you the true stories and experiences from radical remission survivors and the healers and doctors who have helped them overcome a dire prognosis. These episodes are full of stories of hope and inspiration for anyone living with a life-changing diagnosis.
New research at ACR Convergence 2023, the American College of Rheumatology’s annual meeting, demonstrates that CAR-T cell therapy could lead to sustained suppression of autoantibodies in treatment-resistant lupus while maintaining a robust response to vaccines.
Systemic lupus erythematosus (SLE, lupus) is a complex autoimmune disease marked by the production of autoantibodies to nucleic acid DNA and nuclear protein autoantigens and is associated with dysfunctional B cells. It mainly affects women and is more common and severe in people who are Black, Hispanic, or Asian. Lupus can lead to a wide range of systemic problems varying in severity, including skin, kidney, lung, joints, and heart disease and complications during pregnancy.
The disease often requires life-long treatment with immunosuppressive or immunomodulatory drugs, and a considerable number of patients don’t respond to them. One theoretical option for these patients is chimeric antigen receptor (CAR)-T cell therapy, which is successfully used to treat refractory blood cancers by destroying malignant cells.
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The tool can correct genetic errors, control gene activity, and potentially treat diseases like cancer. However, its use raises ethical concerns regarding altering human genes and embryos.
GPT-4 for radiology.
As the benefits of AI in healthcare continue to emerge, we investigate GPT-4’s potential in radiology. Learn about research exploring GPT-4’s potential in assisting report structuring, classifying diseases, and generating comprehensive findings summaries:
Life expectancy and healthy aging in mice can be determined by a protein present in some cells of the immune system, according to a study published in the journal Cell Reports. When this protein—known as the CD300f immune receptor—is absent, animal models have a shorter life expectancy and suffer from pathologies associated with cognitive decline and premature aging, especially in females.
“Our study indicates that alterations in immune system cells, for instance, in macrophages and microglia, can determine the healthy aging degree in mice,” notes Hugo Peluffo, leader of this study and member of the Faculty of Medicine and Health Sciences and the Institute of Neurosciences (UBneuro) of the University of Barcelona.
Understanding how the CD300f immune receptor —and the myeloid cells of the immune system—can determine by themselves the onset rate of aging-associated pathologies, “will help to better understand this process, and it will contribute to the design of strategies to regulate its action. For instance, using the immune receptor CD300f as a target in biomedicine,” notes the expert. “Also, our team has previously shown that some variants of the CD300f immune receptor could be useful as biomarkers in patients.”
NASHVILLE, Tenn. (AP) — A ransomware attack has prompted a healthcare chain that operates 30 hospitals in six states to divert patients from at least some of its emergency rooms to other hospitals, while putting certain elective procedures on pause, the company announced.
In a statement Monday, Ardent Health Services said the attack occurred Nov. 23 and the company took its network offline, suspending user access to its information technology applications, including the software used to document patient care.
The Nashville, Tennessee-based company said it cannot yet confirm the extent of any patient health or financial information that has been compromised. Ardent says it reported the issue to law enforcement and retained third-party forensic and threat intelligence advisors, while working with cybersecurity specialists to restore IT functions as quickly as possible. There’s no timeline yet on when the problems will be resolved.
A new ingestible capsule can monitor vital signs from within the patient’s GI tract. The sensor could be used for less intrusive monitoring of sleep disorders such as sleep apnea, or for detecting opioid overdoses.
Diagnosing sleep disorders such as sleep apnea usually requires a patient to spend the night in a sleep lab, hooked up to a variety of sensors and monitors. Researchers from MIT, Celero Systems, and West Virginia University hope to make that process less intrusive, using an ingestible capsule they developed that can monitor vital signs from within the patient’s GI tract.
The capsule, which is about the size of a multivitamin, uses an accelerometer to measure the patient’s breathing rate and heart rate. In addition to diagnosing sleep apnea, the device could also be useful for detecting opioid overdoses in people at high risk, the researchers say.
New research suggests that biological age, as indicated by DNA methylation, more significantly impacts cognitive abilities like memory and processing speed than chronological age. This finding could reshape our understanding of aging and cognitive health.
Scientists may have figured out a brand new way to treat lung cancer by using a protein that inhibits tumor growth.
This previously unknown molecule pathway could help researchers develop personalized lung cancer treatments, a new study in the journal Proceedings of the National Academy of Sciences (PNAS) reveals.
The researchers found that a protein called RBM10—previously known to be a tumor suppressor—can inhibit the growth of lung cancer by stopping the function of another protein called c-Myc drives cancer cell growth when it is overexpressed in the body.
Researchers have been able to reduce dramatically the level of bad cholesterol in human subjects after injecting them with an experimental gene editing treatment, according to the science journal Nature, which is the first time this technique, called base editing, has been done on humans.
But at least one person died after receiving an infusion, prompting a round of safety concerns.
In the clinical trial, 10 subjects with congenitally high levels of bad cholesterol, aka low-density lipoprotein (LDL), were given an injection of VERVE-101, a gene-editing treatment that uses the base editing technique. This treatment then turned off the gene for the protein PCSK9, which is found in the liver and regulates LDL. High levels of LDL can lead to coronary heart disease.
