Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 2438

If humans are destined for deep space, they need to understand the space environment changes health, including aging and antibiotic resistance.

A new NASA project could help. It aims to develop technology used to study “omics”—fields of microbiology that are important to human health. Omics includes research into genomes, microbiomes and proteomes.

The Omics in Space project is being led by NASA’s Jet Propulsion Laboratory in Pasadena, California. The project was recently funded by NASA’s Translational Research Institute for Space Health four years of study. Over that time, NASA hopes to develop 3D printable designs for instruments on the International Space Station (ISS), that can handle liquids like blood samples without spilling in microgravity. These tools could enable astronauts to analyze biological samples without sending them back to Earth.

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Cancer fighting nanovaccines have shown significant promise, but clinical application has been hampered by complications in large-scale manufacturing, quality control, and safety. Biomedical engineers at the National Institute of Biomedical Imaging and Bioengineering (NIBIB) developed a new technology that enables nanovaccines to bind to the albumin protein naturally present in the body. The albumin protein then delivers these nanocomplexes to the lymph nodes, resulting in potent immune activation against multiple tumor types in mouse cancer models. The use of natural albumin as a universal vaccine shuttle is a significant step towards the application of cancer nanovaccine immunotherapy in humans.

Nanovaccines that work to mount an immune response against a tumor basically consist of two components: the part that delivers the vaccine to the correct site, the lymph nodes, where immune system activation happens; and the part that activates the immune cells to expand and specifically target the tumor.

Schematic of self-assembly of the AlbiVax nanovaccine.

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We wanted to bring your attention to an open-access publication in which the researchers suggest that the age-related decline of the thymus is more important than DNA mutation as a cancer risk factor[1].

Repairing the damage

As we have discussed in this article, cancer is caused by DNA damage that creates mutations. Damage to our DNA happens all the time, and we have various repair systems in place for it.

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The scientists who hope to do this sit on the fringes of the mainstream medical landscape. But there are now a number of research centres around the world that have made identifying ways of preventing biological ageing a priority. Studies in animals have shown that it is indeed possible to dramatically extend the lifespan of certain species, giving hope that it could also be possible in humans.

As we learn more about the diseases that affect us, we also get better at controlling them. But will we ever manage to overcome the most inevitable of afflictions – old age?

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New research from the University of Southern California has shed light on how the decline of the brain’s vascular system precedes the build-up of the plaques and tau tangles associated with Alzheimer’s disease.

A leaky blood-brain barrier sets the scene for dementia

Traditionally, many researchers have focused their efforts on the amyloid and tau proteins that accumulate in the brain and are typical of Alzheimer’s disease progression. However, the researchers in this new study suggest that the problem begins before this due to a leaking blood-brain barrier [1].

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