Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 2,389

Here, we will first summarize the experimental achievements over the last 7 years in cell and animal rejuvenation. Then, a comparison will be made between the principles of the cumulative DNA damage theory of aging and the basic facts underlying the epigenetic model of aging, including Horvath’s epigenetic clock. The third part will apply both models to two natural processes, namely, the setting of the aging clock in the mammalian zygote and the changes in the aging clock along successive generations in mammals. The first study demonstrating that skin fibroblasts from healthy centenarians can be rejuvenated by cell reprogramming was published in 2011 and will be discussed in some detail. Other cell rejuvenation studies in old humans and rodents published afterwards will be very briefly mentioned. The only in vivo study reporting that a number of organs of old progeric mice can be rejuvenated by cyclic partial reprogramming will also be described in some detail. The cumulative DNA damage theory of aging postulates that as an animal ages, toxic reactive oxygen species generated as byproducts of the mitochondria during respiration induce a random and progressive damage in genes thus leading cells to a progressive functional decline. The epigenetic model of aging postulates that there are epigenetic marks of aging that increase with age, leading to a progressive derepression of DNA which in turn causes deregulated expression of genes that disrupt cell function. The cumulative DNA damage model of aging fails to explain the resetting of the aging clock at the time of conception as well as the continued vitality of species as millenia go by. In contrast, the epigenetic model of aging straightforwardly explains both biologic phenomena. A plausible initial application of rejuvenation in vivo would be preventing adult individuals from aging thus eliminating a major risk factor for end of life pathologies. Further, it may allow the gradual achievement of whole body rejuvenation.

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A ‘pacemaker’ for the brain is on the horizon to prevent people with Parkinson’s and epilepsy suffering from seizures and tremors.

The device is made up of two tiny array of electrodes which sit inside the skull, and link to a circuit board on the side of the head.

The ‘pacemaker’ records the normal electrical current of the brain continually and if it notices a change of rhythm immediately fires a stimulating charge to coax the pulse back to normal.

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For several decades now, one of the buzz words in the medical field has been ‘stem cell’. It has been said to aid in treating illnesses like multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease, and heart diseases.

For the past three years, researchers at the Hubrecht Institute in the Netherlands have been painstakingly cataloging and mapping all the proliferating cells found in mouse hearts, looking for cardiac stem cells. The elusive cells should theoretically be able to repair damaged heart muscle, so the stakes in finding them have been high.

This week, however, Proceedings of the National Academy of Sciences is scheduled to announce the results of the Hubrecht team’s work: no evidence of cardiac stem cells at all.

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An injection capable of halting the progress of Alzheimer’s could be available to patients within a decade, Britain’s leading dementia organisation predicts.

The Alzheimer’s Society says a series of recent breakthroughs in treatments that disrupt harmful genes has brought scientists to a “tipping point” in their fight against the disease.

For decades, researchers have sought without success a treatment for Alzheimer’s based on targeting damaging proteins that build up in the brain.

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A quick and easy test devised by scientists from the University of Queensland could transform cancer diagnosis as we know it.

Cancer is a difficult disease to diagnose because different types are characterised by different signatures. Until now, scientists have been unable to find a unique signature common to all forms of cancer that would set it apart from healthy cells.

That’s what University of Queensland researchers Dr Laura Carrascosa, Dr Abu Sina and Professor Matt Trau have addressed. They have discovered a unique DNA nanostructure that seems to be common to all types of cancer and is visible when cancer cells are placed in water.

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In 1961, Nancy Grace Roman was already the first Chief of Astronomy in NASA’s Office of Space Science. She developed that program in a time before the second wave of the Women’s Movement in the United States began, when banks often refused women credit in their own names and there was still an active medical debate about whether women could ever physically endure spaceflight someday. But Roman opened the skies to humanity in new ways without ever leaving the ground.

She earned her Ph.D. in astronomy at the University of Chicago in 1949 and worked at the Yerkes Observatory there for six years afterward. She joined the radio astronomy group at the Naval Research Laboratory, becoming the head of the microwave spectroscopy section. As she recalled in 1980 in an oral history interview with National Air and Space Museum curator David DeVorkin, when she heard that NASA might set up a space astronomy program, she wanted to lead it: “The idea of coming in with an absolutely clean slate to set up a program that I thought was likely to influence astronomy for 50 years was just a challenge that I couldn’t turn down. That’s all there is to it.” She joined NASA in 1959, just after the agency’s founding.

Roman opened the skies to humanity in new ways without ever leaving the ground.

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In 2016, a mysterious illness spread inside the National Institutes of Health’s Clinical Center, the U.S. government’s most prominent research hospital, in Bethesda, Maryland. Patients were somehow being sickened by an antibiotic-resistant strain of bacteria that practically never causes disease in humans. Two years later, a new study seems to finally have confirmed where this bug likely came from: the hospital’s own plumbing.

During a six-month period in 2016, six patients came down with infections caused by Sphingomonas bacteria. Four of the patients had an antibiotic-resistant strain of a particular species, Sphingomonas koreensis, which was first discovered in some of Korea’s natural mineral water spots in the early 2000s.

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