Lifeboat Foundation

A research team led by Dr. Cai at the Albert Einstein college of medicine have shown that stem cells in the hypothalamus influence how fast we age. The new research, shown in mice, may lead to approaches that delay or even prevent age-related diseases[1].

Unfortunately like 70% of scientific research, this publication is behind a paywall, so those wishing to read will have to use the usual channels to obtain the publication. We discuss why paywalls are an unacceptable barrier to progress here in our interview with Sci-Hub.

Imagine a world in which you’re 90 years old and nowhere near middle-aged. An app on your phone has hacked your DNA code, so you know exactly when to go to the doctor to receive gene therapy to prevent all the diseases you don’t yet have. A microchip in your skin sends out a signal if you’re at risk of developing a wrinkle — so you step out of the sun and hotfoot it to your dermatologist. Every evening you sync your brain-mapping device with The Cloud, so even if you were caught up in a fatal accident you’d still be able to cheat death — every detail of your life would simply be downloaded to one of the perfect silicon versions you’d had made of yourself, ensuring you last until at least your 1,000th birthday.

This may sound like science fiction but it could be your fate — provided you can afford it. If current research develops into medicine, in the London of the future the super-rich won’t simply be able to buy the best things in life, they’ll be able to buy life itself by transforming themselves into a bio-engineered super-race, capable of living, if not forever, then for vastly longer than the current UK life expectancy of 81 years.

The science of turning back the clock has never been more advanced. In Boston, a drug capable of reversing half a lifetime of ageing in mice is about to be tested on humans in a medical trial monitored by NASA. NMN is a compound found naturally in broccoli which boosts levels of NAD, a protein involved in energy production that depletes as we get older. Professor David Sinclair, who headed up the initial research at Australia’s University of New South Wales, doses himself with 500mg daily, and claims that he has already become more youthful. According to blood tests analysing the state of the 48-year-old’s cells, prior to taking the pills Sinclair was in the same physical shape as a 57-year-old, but now he’s ‘31.4’.

Continue reading “Why the super-rich are ploughing billions into the booming ‘immortality industry’” »

It is a command that led the leading atheist Richard Dawkins to claim that the God of the Old Testament was “a vindictive, bloodthirsty ethnic cleanser … a genocidal … megalomaniacal, sadomasochistic, capriciously malevolent bully”.

For God had ordered the Israelites to slaughter the apparently sinful Canaanites, saying: “You shall not leave alive anything that breathes. But you shall utterly destroy them.” And, according to the Bible, they did just that.

However, a new genetic study has found that the Canaanites actually managed to survive this purge of their traditional homeland, passing on their DNA over the centuries to their numerous descendants in modern-day Lebanon.

Continue reading “Bible says Canaanites were wiped out by Israelites but scientists just found their descendants living in Lebanon” »

In the hopes of rising above the laws and regulations of terrestrial nations, a group of Silicon Valley millionaires has bold plans to build a floating city in Tahiti, French Polynesia. It sounds like the start of a sci-fi dystopia (in fact, this is the basic premise behind the video game Bioshock), but the brains behind the project say their techno-libertarian community could become a paradise for technological entrepreneurship and scientific innovation.

The Seasteading Institute was set up in 2008 by billionaire PayPal founder Peter Thiel and software engineer, poker player, and political economic theorist Patri Friedman. Both ardent libertarians, their wide-eyed mission is to “establish permanent, autonomous ocean communities to enable experimentation and innovation with diverse social, political, and legal systems.”

“Seasteading will create unique opportunities for aquaculture, vertical farming, and scientific and engineering research into ecology, wave energy, medicine, nanotechnology, computer science, marine structures, biofuels, etc,” their website reads.

Continue reading “Floating City Project Wants To Make An ‘Unregulated’ Hub Of Scientific Research” »

Reports suggest researchers have altered DNA and made few errors.

• By Sharon Begley, STAT on July 27, 2017

The Eureka science show recently featured one of the leaders of the Transhumanist movement which believes humans will transcend disease and delay mortality indefinitely.

Scientists at Albert Einstein College of Medicine have found that stem cells in the brain’s hypothalamus govern how fast aging occurs in the body. The finding, made in mice, could lead to new strategies for warding off age-related diseases and extending lifespan. The paper was published online today in Nature.

The hypothalamus was known to regulate important processes including growth, development, reproduction and metabolism. In a 2013 Nature paper, Einstein researchers made the surprising finding that the hypothalamus also regulates aging throughout the body. Now, the scientists have pinpointed the cells in the hypothalamus that control aging: a tiny population of adult neural stem cells, which were known to be responsible for forming new brain neurons.

“Our research shows that the number of hypothalamic neural stem cells naturally declines over the life of the animal, and this decline accelerates aging,” says senior author Dongsheng Cai, M.D., Ph.D., (professor of molecular pharmacology at Einstein. “But we also found that the effects of this loss are not irreversible. By replenishing these stem cells or the molecules they produce, it’s possible to slow and even reverse various aspects of aging throughout the body.”

Rewriting Life

First Human Embryos Edited in U.S.

Researchers have demonstrated they can efficiently improve the DNA of human embryos.

Continue reading “EXCLUSIVE: First human embryos edited in U.S., using CRISPR” »

The unique swimming strategies of natural microorganisms have inspired recent development of magnetic micro/nanorobots powered by artificial helical or flexible flagella. However, as artificial nanoswimmers with unique geometries are being developed, it is critical to explore new potential modes for kinetic optimization. For example, the freestyle stroke is the most efficient of the competitive swimming strokes for humans. Here we report a new type of magnetic nanorobot, a symmetric multilinked two-arm nanoswimmer, capable of efficient “freestyle” swimming at low Reynolds numbers. Excellent agreement between the experimental observations and theoretical predictions indicates that the powerful “freestyle” propulsion of the two-arm nanorobot is attributed to synchronized oscillatory deformations of the nanorobot under the combined action of magnetic field and viscous forces. It is demonstrated for the first time that the nonplanar propulsion gait due to the cooperative “freestyle” stroke of the two magnetic arms can be powered by a plane oscillatory magnetic field. These two-arm nanorobots are capable of a powerful propulsion up to 12 body lengths per second, along with on-demand speed regulation and remote navigation. Furthermore, the nonplanar propulsion gait powered by the consecutive swinging of the achiral magnetic arms is more efficient than that of common chiral nanohelical swimmers. This new swimming mechanism and its attractive performance opens new possibilities in designing remotely actuated nanorobots for biomedical operation at the nanoscale.

Each bot is 5 micrometres long and has three main parts, connected together like sausage links by two silver hinges. Its gold body is flanked by two magnetic arms made of nickel, and applying a magnetic field to the tiny robot makes the arms move.

The next generation bloodstream will be made from biodegradable materials before they can be used in the bloodstream. Less complicated areas in the human body like the urinary tract or the eyeballs should see clinical trials begin within the next five to 10 years. Injecting a single swimmer into an eyeball, where it could deliver medication directly to the retina and then be removed, would be much less complicated than letting a swarm of them swim throughout the entire circulatory system.

Continue reading “Fast, Efficient bloodstream robots” »