Chinese official house arrest their people under threat of coronavirus coronavirus-chinese-officials-lock-people-homes-ban-funerals-weddings-zhejiang.
In four cities that are home to more than 30 million people, each household is given a so-called passport. It permits one person to leave every two days.
SANTA CLARA COUNTY, Calif. (KRON) — County officials have extended their declaration of a local health emergency in Santa Clara County due to the coronavirus outbreak.
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Officials stressed that this does not mean there is an increased risk to the public.
A scrupulous gatekeeper stands between the brain and its circulatory system to let in the good and keep out the bad, but this porter, called the blood-brain barrier, also blocks trial drugs to treat diseases like Alzheimer’s or cancer from getting into the brain.
Now a team led by researchers at the Georgia Institute of Technology has engineered a way of studying the barrier more closely with the intent of helping drug developers do the same. In a new study, the researchers cultured the human blood-brain barrier on a chip, recreating its physiology more realistically than predecessor chips.
The new chip devised a healthy environment for the barrier’s central component, a brain cell called the astrocyte, which is not a neuron, but which acts as neurons’ intercessors with the circulatory system. Astrocytes interface in human brains with cells in the vasculature called endothelial cells to collaborate with them as the blood-brain barrier.
Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. Here, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink® Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N = 798), Lothian Birth Cohort 1921 (LBC1921, N = 165), and the INTERVAL BioResource (N = 4451). In the LBC1936, 22 of the proteins were significantly associated with general fluid cognitive ability (β between −0.11 and −0.17). MRI-assessed total brain volume partially mediated the association between 10 of these proteins and general fluid cognitive ability. In an age-matched subsample of INTERVAL, effect sizes for the 22 proteins, although smaller, were all in the same direction as in LBC1936. Plasma levels of a number of neurology-related proteins are associated with general fluid cognitive ability in later life, mediated by brain volume in some cases.
Osteoarthritis is one of the most common ailments of an aging population, but there aren’t many treatment options besides taking pain killers or getting a full joint replacement. Now, researchers at the Salk Institute have found that a combination of two experimental drugs appears to reverse the symptoms of the disorder, with successful tests conducted in rats and in human cells in the lab.
As we age, our bodies gradually lose the ability to repair damage as fast as it needs to. That means that tissues subjected to high-intensity long-term use, such as cartilage in joints, are especially prone to wearing out. That manifests itself in the common condition of osteoarthritis, resulting in pain when that joint moves.
In the past, two molecules have been identified as having decent potential for treating the disease – alpha-KLOTHO (αKLOTHO) and TGF beta receptor 2 (TGFβR2). Previous tests only showed moderate success, so the researchers on the new study decided to see if they fared any better when used together.
Very interesting, researches probably already know.
You awake in the middle of the night from a nightmare.
In the nightmare, you are standing in a room that is completely full, floor to ceiling, of balloons. There are red ones, purple ones, yellow ones and green ones.
You’ve been told to burst only the green and purple balloons. Bursting the red or yellow ones will have disastrous consequences.
