Over 85 percent of proteins in the body can’t be targeted with conventional chemical drugs. By working on the RNA responsible for problematic proteins, gene silencing opens up an enormous portion of the genome to intervention. If realized, a new class of drugs based on gene silencing could overhaul modern medicine.
An international team of researchers led by a group with deCODE Genetics, a biopharmaceutical company in Iceland, has partly recreated the DNA of a man who died in 1827, despite having no body to take tissue samples from. In their paper published in the journal Nature Genetics, the team describes reconstructing “a sizable portion” of the original DNA of the man by studying DNA samples from his descendants.
In a unique and interesting project, the team worked with genetic information from people living in Iceland to recreate the DNA of a man well known in that country due to his unique story. He was an escaped black slave who made his way to Iceland—a place where there were no other people of African descent. That made his DNA extremely unique. More importantly, the man, Hans Jonatan, was, as the story goes, “welcomed with open arms,” which meant he was able to marry a local woman and have children. Those children produced children of their own, who inherited part of Jonatan’s DNAdding to the story, Iceland just happens to have one of the most extensive genealogical databases in the world today—it includes data on over a third of the entire population of the country.
In this new effort, the researchers took advantage of the unique situation to find Jonatan’s descendants by narrowing an original pool of 788 descendants down to a manageable 182—each one of whom held one small piece of the puzzle in their genes. After much work, the team reports that they were able to use the pieces they found to recreate a large part of Jonatan’s DNA without using any tissue from him at all—the first time such a feat has ever been achieved. They were also able to trace some of Jonatan’s ancestry starting with his mother, an African slave on a plantation in St. Croix, which at the time of Jonatan’s birth was a Danish colony. They believe his father was a white European.
The lamprey looks about as different from a human as you can imagine. This fish has an eel-like, finless body, bulging eyes, and a circle of frankly horrifying teeth in place of a jaw, which some species use to latch onto other animals and suck their blood.
Yet these alien-looking creatures share something fairly extraordinary with humans: we both contain genes that, in the lamprey, allows it to repair broken spinal cords.
The discovery shows promise for medicine: if we could one day activate the same gene in humans, we could reverse spinal cord damage — even paralysis.
Continue reading “Humans Share a Relevant Gene With This Fish That Can Repair Its Spinal Cord” »
Distinct amyloid-beta prion strains discovered in different variants of Alzheimer’s disease.
In a paper in the Proceedings of the National Academy of Sciences, a research team led by Carlo Condello presented their results from a study of the sliced brain fragments of deceased Alzheimer’s disease (AD) patients. It appears different amyloid-beta prions are uniquely associated with different AD variants [1].
A primer on Alzheimer’s disease
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An interview with Drs. Irina and Michael Conboy on the topic of young blood and blood filtering for rejuvenation purposes.
Due to a recently published study on the effects of young plasma on aged mice, we got in touch with Dr. Irina Conboy of Berkeley University. Dr. Conboy is an Associate Professor at the Department of Bioengineering and an expert in stem cell niche engineering, tissue repair, stem cell aging and rejuvenation. Before we dive into the main topic, let’s familiarize ourselves a little with Dr. Conboy and her work.
Dr. Conboy got her Ph.D. at Stanford University, focusing on autoimmunity. She met her partner in science—and in life—Dr. Michael Conboy at Harvard and they got married before embarking on graduate studies; they celebrated their Silver Anniversary a few years ago. During her postdoctoral studies, she began focusing on muscle stem cells, trying to figure out what directs them to make new healthy tissue and what causes them to lose their ability to regenerate the tissues they reside in as we age[1].
Continue reading “Could Filtering Our Aged Blood Keep us Young?” »
https://www.youtube.com/watch?v=dmd7-KjE62o&feature=share
For your scrutiny. This is about the 90+ year old father of Mel Gibson getting stem cell therapy and Joe Rogan talking about Bas Ruten getting the same. According to this doctor these treatments are not available in the U.S.
Joe Rogan, Mel Gibson and Dr. Neil Riordan talk about stem cell therapy and how it saved Mel Gibson’s Dad, on The Joe Rogan Experience, JRE 1066. Full podcast — https://www.youtube.com/watch?v=OtL1fEEtLaA
Continue reading “Joe Rogan & Mel Gibson on Stem Cell Therapy” »
