Biohacking for cures: what you need to know.
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Category: biotech/medical – Page 2315
That conclusion is based on a study that reviewed genetic testing results from 1.45 million individuals and found that nearly 25 percent of “variants of uncertain significance” were subsequently reclassified — sometimes as less likely to be associated with cancer, sometimes as more likely.
The study appears in the Journal of the American Medical Association (JAMA).
When variations from the norm are discovered in a gene, the variants are classified as “benign,” “likely benign,” “variant of uncertain significance,” “likely pathogenic,” or “pathogenic.”
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Certainly, there are those in the movement who espouse the most extreme virtues of transhumanism such as replacing perfectly healthy body parts with artificial limbs. But medical ethicists raise this and other issues as the reason why transhumanism is so dangerous to humans when what is considered acceptable life-enhancement has virtually no checks and balances over who gets a say when we “go too far.” For instance, Kevin Warwick of Coventry University, a cybernetics expert, asked the Guardian, “What is wrong with replacing imperfect bits of your body with artificial parts that will allow you to perform better – or which might allow you to live longer?” while another doctor stated that he would have “no part” in such surgeries. There is, after all, a difference between placing a pacemaker or performing laser eye surgery on the body to prolong human life and lend a greater degree of quality to human life, and that of treating the human body as a tabula rasa upon which to rewrite what is, effectively, the natural course of human life.
While many https://whatistranshumanism.org/#what-is-a-transhuman” target=”_blank” rel=” nofollow noopener noreferrer” data-ga-track=” ExternalLink: https://whatistranshumanism.org/#what-is-a-transhuman”> transhumanist ideals remain purely theoretical in scope, what is clear is that females are the class of humans who are being theorised out of social and political discourse. Indeed, much of the social philosophy surrounding transhumanist projects sets out to eliminate gender in the human species through the application of advanced biotechnology and assisted reproductive technologies, ultimately inspired by Shulamith Firestone’s https://teoriaevolutiva.files.wordpress.com/2013/10/fireston…lution.pdf” target=”_blank” rel=” nofollow noopener noreferrer” data-ga-track=” ExternalLink: https://teoriaevolutiva.files.wordpress.com/2013/10/fireston…lution.pdf”> The Dialectic of Sex and much of Donna Haraway’s writing on https://warwick.ac.uk/fac/arts/english/currentstudents/under…sm_in_the_…pdf” target=”_blank” rel=” nofollow noopener noreferrer” data-ga-track=” ExternalLink: https://warwick.ac.uk/fac/arts/english/currentstudents/under…sm_in_the_…pdf”> cyborgs. From parthenogenesis to the creation of artificial wombs, this movement seeks to remove the specificity of not gender, but sex, through the elision of medical terminology and procedures which portend to advance a technological human-cyborg built on the ideals of a post-sex model.
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Highly specialized cartilage is characteristically avascular and non-neural in composition with low cell numbers in an aliphatic environment. Despite its apparent simplicity, bioengineering regenerative hyaline cartilage in a form effective for implantation remains challenging in musculoskeletal tissue engineering. Existing surgical techniques including autologous chondrocyte implantation (ACI) and matrix-induced autologous chondrocyte implantation (MACI) are considered superior to self-repair induction techniques. However, both MACI and ACI are complex, multistage procedures that require a double operation; first for surgical excision of native cartilage, followed by expansion of adult chondrocytes in vitro prior to implantation by a second operation.
Regenerating robust articular hyaline-like cartilage is a key priority in musculoskeletal tissue engineering to prevent cost-intensive degenerative osteoarthritis that limits the quality of life in global healthcare. Integrating mesenchymal stem cells and 3D printing technologies has shown significant promise in bone tissue engineering– although the key challenge remains in transferring the bench-based technology to the operating room for real-time applications. To tackle this, a team of Australian orthopedic surgeons and bioengineers collaboratively proposed an in situ additive manufacturing technique for effective cartilage regeneration. The handheld engineered extrusion device known as the BioPen offers an advanced, co-axial extrusion strategy to deposit cells embedded in a hydrogel material within a surgical setting.
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Today, we have an interview with Dr. Michael Bonkowski, an expert on NAD+ biology and aging from the David Sinclair Lab, Harvard Medical School.
Michael Bonkowski aims to advance our understanding of the links between metabolism, aging, and age-associated diseases. He has published 35 peer-reviewed journal articles and has conducted multiple successful longevity studies. In Dr. David Sinclair’s lab, his research efforts are focused on the role of nutrient sensors’ regulation of endocrine signaling and aging in the mouse. He is also working on direct and indirect ways to drive the activity of these nutrient sensors by using dietary manipulations, small molecules, and chemical treatments.
Michael is trained as a pharmacologist, physiologist, and animal scientist. Some of his areas of expertise include animal physiology, genetics, glucose, and insulin homeostasis, metabolism, assay development, protein biochemistry, and transmission electron microscopy imaging.
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Researchers at the University of Glasgow have developed a small handheld device that can scan for biomarkers to quickly and easily diagnose people with certain diseases and illnesses. Inspired (as always) by Star Trek’s tricorder, the new “multicorder” is designed to help doctors track the presence or progression of an illness from just about anywhere.
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A duty to die at 75 by law?! No need to cure one disease because anyway you will die from another after 65?! A new article uncovers the dangers of going to ‘healthy’ and not longer lifespan:
2) A duty to die becomes greater as you grow older. As we age, we will be giving up less by giving up our lives, if only because we will sacrifice fewer remaining years of life and a smaller portion of our life plans… To have reached the age of, say, seventy-five or eighty years without being ready to die is itself a moral failing, the sign of a life out of touch with life’s basic realities.
3) A duty to die is more likely when you have already lived a full and rich life. You have already had a full share of the good things life offers.
Most bioethicists who denigrate the equal importance of the lives of the elderly and/or who promote age-based health-care-rationing schemes are not as explicit or impolitic in their advocacy as Hardwig. But changing the “primary goal of medicine” to “healthspan” — if involuntary or based on policy — would come perilously close to justifying that same utilitarian end.
Researchers have used gene editing to completely eliminate populations of mosquitoes in the lab.
The team tested their technique on the mosquito Anopheles gambiae, which transmits malaria.
They altered part of a gene called doublesex, which determines whether an individual mosquito develops as a male or as a female.
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