(ASX: PXS) has announced that its novel topical drug treatment for scarring has delivered positive phase one clinical trial results and will now advance to the next stage of development in patients.
Category: biotech/medical – Page 2,216
Scientists identify novel mechanism that links genetic defect in IBD patients to gut leakiness
The cumulative effect of reduced PTPN2 activity on both mechanisms was an elevated fluid loss. The researchers proved this defect could be reversed by treating cells lacking PTPN2 with recombinant -; or synthetic -; matriptase.
A team of researchers led by a biomedical scientist at the University of California, Riverside, has identified a novel mechanism by which loss-of-function mutations in the gene PTPN2, found in many patients with inflammatory bowel disease, or IBD, affect how intestinal epithelial cells maintain a barrier.
The intestinal epithelium, a single layer of cells, plays a critical role in human health by providing a barrier while also allowing nutrient and water absorption. Intestinal epithelial cells are needed for regulating immune function, communicating with the intestinal microbiota, and protecting the gut from pathogen infection -; all of which critically depend on an intact epithelial barrier.
Affecting roughly 3 million Americans, IBD is a set of chronic intestinal diseases in which the lining of the gut becomes inflamed and leaky. Increased gut leakiness has recently been confirmed to increase the risk of developing IBD.
New bioink brings 3D-printing of human organs closer to reality
Researchers at Lund University have designed a new bioink which allows small human-sized airways to be 3D-bioprinted with the help of patient cells for the first time. The 3D-printed constructs are biocompatible and support new blood vessel growth into the transplanted material. This is an important first step towards 3D-printing organs.
Therefore, researchers are looking at ways to increase the amount of lungs available for transplantation. One approach is fabricating lungs in the lab by combining cells with a bioengineered scaffold.
Announcing the in-person book launch of “The Illusion of Knowledge: The paradigm shift in aging research that shows the way to human rejuvenation” with the presence of the author
Dr. The book launch will happen on September 4th, at 3 p.m. (Pacific Time) in Book Passage Ferry Building Store in San Francisco, California!
Please come to have an in-person chat with Dr. Katcher.
Dr. Harold Katcher is one of the discoverers of the human breast cancer gene (BRCA1), and has thousands of citations in the scientific literature, with publications ranging from protein structure to bacteriology, biotechnology, bioinformatics and biochemistry. He was the Academic Director for Natural Sciences for the Asian Division of the University of Maryland Global Campus, and nowadays is Chief Scientific Officer at Yuvan Research Inc., which is working on the development of rejuvenation treatments.
https://www.bookpassage.com/event/harold-katcher-illusion-kn…ding-store.
https://www.ntzplural.com/harold-katcher-launches-book.
https://www.facebook.com/events/553354852782737?ref=newsfeed.
#haroldkatcher #sanfrancisco #california #booklaunch #biotechnology #rejuvenation #aging.
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A Vaccine To Prevent Cancer Evolution
A cancer vaccine could be an effective way to prevent cancer from evolving and becoming resistant to treatment, new research suggests.
Scientists were investigating the use of a cancer-killing virus in clinical trials, and observed, as they had also seen in mice, that although some patients initially responded to the treatment, their tumours soon became resistant.
The researchers showed that the specific mutations causing tumour cells to become resistant to the viral treatment, could be anticipated and exploited using a vaccine which, when tested in mice, was shown to trigger the immune system to destroy treatment resistant tumour cells.
Scientists have developed a cancer vaccine that in mice was shown to trigger the immune system to destroy treatment-resistant tumor cells.
AI Can Predict Possible Alzheimer’s With Nearly 100 Percent Accuracy
Summary: A new AI algorithm can predict the onset of Alzheimer’s disease with an accuracy of over 99% by analyzing fMRI brain scans.
Source: Kaunas University of Technology.
Researchers from Kaunas University, Lithuania developed a deep learning-based method that can predict the possible onset of Alzheimer’s disease from brain images with an accuracy of over 99 percent. The method was developed while analyzing functional MRI images obtained from 138 subjects and performed better in terms of accuracy, sensitivity, and specificity than previously developed methods.
Drugs to use, avoid when treating COVID-19: Top health system physicians weigh in
More than 18 months into the COVID-19 pandemic, there are still very few drugs authorized by the FDA to treat the virus. Just one drug, remdesivir, has gained full FDA approval as a treatment for COVID-19.
Becker’s asked physicians from top health systems which medications they’re using most frequently to treat their COVID-19 patients, which they’re avoiding and which have been most effective.
Researchers use organic semiconductor nanotubes to create new electrochemical actuator
University of Houston researchers are reporting a breakthrough in the field of materials science and engineering with the development of an electrochemical actuator that uses specialized organic semiconductor nanotubes (OSNTs).
Currently in the early stages of development, the actuator will become a key part of research contributing to the future of robotic, bioelectronic and biomedical science.
“Electrochemical devices that transform electrical energy to mechanical energy have potential use in numerous applications, ranging from soft robotics and micropumps to autofocus microlenses and bioelectronics,” said Mohammad Reza Abidian, associate professor of biomedical engineering in the UH Cullen College of Engineering. He’s the corresponding author of the article “Organic Semiconductor Nanotubes for Electrochemical Devices,” published in the journal Advanced Functional Materials, which details the discovery.