Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 2,177

Two recent studies highlight novel ways to combat pattern hair loss in men and women using small molecules such as JAK inhibitors that reawaken dormant hair follicles, as well as stem cell therapies aimed at growing new follicles.

In the first study, researchers led by Angela Christiano, Ph.D., the Richard & Mildred Rhodebeck Professor of Dermatology at Columbia University Vagelos College of Physicians and Surgeons, discovered previously unknown cells that keep mouse follicles in a resting state and show that inhibiting the activity of these cells can reawaken dormant follicles.

In a second study, Christiano’s team created a way to grow human hair in a dish, which could open up hair restoration surgery to more people, including women, and improve the way pharmaceutical companies search for new hair-growth drugs.

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Individuals that are experiencing frequent migraines, may soon receive access to a new class of medications.

A pair of large studies showed that two drugs have the ability to reduce the frequency of the migraine attacks, without any side effects. The researchers report in the New England Journal of Medicine that the drugs offer the first ever migraine treatment that is aimed at the disorder itself, instead of the symptoms.

Current migraine treatments consist of drugs that are designed to treat epilepsy, depression and high blood pressure. Peter Goadsby, an author of one of the studies in question and a professor at King’s College in London says that they give the patients a choice between antidepressants that will make them sleepy, and a beta blocker, which will make them feel tired.

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Until the day he died, in 2011, Robert Ettinger hoped humanity would figure out a way to cheat death. Today, his body is stored in a chamber filled with liquid nitrogen and frozen to −196 °C. He lies in cryopreservation at the Cryonics Institute in Michigan—which he founded—alongside his late mother, his first and second wives, and 150 other deceased.

Ettinger, known as the “father of cryonics,” popularized the idea in his 1962 book The Prospect of Immortality. (Isaac Asimov, the renowned biochemist and science-fiction writer, helped Ettinger publish the book.) Cryonicists believe that technology will sufficiently advance to a point where cells can be rejuvenated and the aging process reversed. In practice, legally deceased patients arrive at a cryonics facility packed in ice. Cryonicists interrupt the dying process by draining the blood from the body and perfusing the corpse with a mixture of anti-freeze and organ-preserving chemicals, known as cryoprotective agents. The body is then transformed into a vitrified state and lowered into a below-freezing chamber filled with liquid nitrogen, where it lies in wait for a future generation to restore it.

“We Will Live Again” was directed by Myles Kane and Josh Koury (http://www.brooklynundergroundfilms.com). It is part of The Atlantic Selects, an online showcase of short documentaries from independent creators, curated by The Atlantic.

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Biochips are essentially tiny laboratories designed to function inside living organisms, and they are driving next-generation DNA sequencing technologies. This powerful combination is capable of solving unique and important biological problems, such as single-cell, rare-cell or rare-molecule analysis, which next-generation sequencing can’t do on its own.

Now that the scaling and throughput power of biochip technologies has emerged, the next trend in biochips will involve being capable of providing applications across a wide spectrum—from identifying rare bacterium to population-based .

In APL Bioengineering a group of researchers from Seoul National University explore the role advancements in biochip technology are playing in driving groundbreaking scientific discoveries and breakthroughs in medicine via next-generation sequencing, aka sequencing.

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Exercise really does influence how we age, and a new study shows how regular exercise in later life can help offset the decline of NAD+ and NAMPT, two important molecules that facilitate cellular energy production, in skeletal muscle.

NAD+ and mitochondria

The mitochondria are the power stations of the cell and provide the energy that our cells need in order to function. As we age, our mitochondria become increasingly dysfunctional and inefficient, and they produce excessive waste in the form of free radicals, which bounce around the interior of the cell, striking and damaging the cellular machinery within.

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Research from Johns Hopkins Medicine has revealed some cases of schizophrenia can be associated with abnormal protein buildup in the brain similar to that seen in cases of Alzheimer’s and other neurodegenerative disorders. It’s hoped the discovery will lead to better diagnostic strategies identifying specific types of schizophrenia.

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The formation of air bubbles in a liquid appears very similar to its inverse process, the formation of liquid droplets from, say, a dripping water faucet. But the physics involved is actually quite different, and while those water droplets are uniform in their size and spacing, bubble formation is typically a much more random process.

Now, a study by researchers at MIT and Princeton University shows that under certain conditions, bubbles can also be coaxed to form spheres as perfectly matched as droplets.

The new findings could have implications for the development of microfluidic devices for biomedical research and for understanding the way interacts with petroleum in the tiny pore spaces of underground rock formations, the researchers say. The findings are published today in the journal PNAS, in a paper by MIT graduate Amir Pahlavan Ph.D. ‘18, Professor Howard Stone of Princeton, MIT School of Engineering Professor of Teaching Innovation Gareth McKinley, and MIT Professor Ruben Juanes.

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