Lifeboat Foundation

A team of researchers at the University of Texas has found NAD+ synthesis and consumption integrate glucose metabolism and adipogenic transcription during adipocyte differentiation. In their paper published in the journal Science, the group describes their research into how glucose is converted into fat in the body and what they found. Sophie Trefely and Kathryn Wellen with the University of Pennsylvania and Drexel University, respectively, offer a Perspective piece on the work done by the team in Texas in the same journal issue.

As obesity rates continue to climb around the globe, scientists continue to explore why it is happening. In addition to studying the psychological aspects involved, scientists would also like to better understand why eating too much makes people gain weight. In this new effort, the researchers looked more closely into why consuming too much glucose causes the body to produce fat.

Prior research has shown that nicotinamide adenine dinucleotide (NAD) is an important molecule that plays a role in a wide variety of physiological and pathological processes. Its oxidized form, NAD+, has also been found to act as a cofactor in metabolic pathways, and more importantly, perhaps, is consumed by various enzymes. Once consumed, NAD+ is broken down into nicotinamides and ADP-ribose. This, the researchers note, means that NAD+ must be resynthesized for normal cellular function to continue. They further note that some prior research has suggested that lower-than-normal levels of NAD+ can alter metabolism, leading in some cases to higher disease susceptibility.

Continue reading “Researchers find glycolysis links to gene transcription via NAD+” »

A discussion on whether or not extended lifespans might make us paranoid about every tiniest risk.

Some months back, I read “Sapiens: A Brief History of Humankind” by Yuval Noah Harari. It’s a really good book, though it did disappoint me significantly when, after discussing the past and the present of our species, the author began glancing towards possible futures. At that point, the impartiality required of a historian, which Harari had thus far managed to keep up more or less evenly throughout the book, gave way to a subtly implied pessimism pervading, among other things, his views on future rejuvenation biotechnology.

Honestly, I wasn’t expecting him to even touch upon the subject; I was pleasantly surprised, at least until I realized that his concerns, most of which were the usual ones you’d expect, seemed to make him inclined to see rejuvenation as a plague rather than a blessing.

Continue reading “On life extension and risk aversion” »

Sutton et al. conduct the first supervised controlled feeding trial to test whether intermittent fasting has benefits in humans in the absence of weight loss. Prediabetic men following a form of intermittent fasting called early time-restricted feeding improved their insulin sensitivity, blood pressure, and oxidative stress levels without losing weight.

When you take a picture of a cat and Google’s algorithms place it in a folder called “pets,” with no direction from you, you’re seeing the benefit of image recognition AI. The exact same technology is used by doctors to diagnose diseases on a scale never before possible by humans.

Diabetic retinopathy, caused by type two diabetes, is the fastest-growing cause of preventable blindness. Each of the more than 415 million people living with the disease risks losing their eyesight unless they have regular access to doctors.

In countries like India there are simply too many patients for doctors to treat. There are 4,000 diabetic patients for every ophthalmologist in India, where the US has one for every 1,500 patients.

Continue reading “Seeing is believing: How AI could prevent blindness for 415 million people (right now)” »

Drones that monitor crops, control mosquito populations and deliver defibrillators are to be tested in US airspace.

Ten commercial drone projects have been selected to try out new ways for unmanned aircraft to be integrated into the skies.

They include Zipline, which currently offers a blood-delivery service in Rwanda, and Apple.

Continue reading “US commercial drones given green light” »

In a first for United States Army doctors, Burrage received an ear transplant that was grown from her own tissue inside her own body. A team, led by Lieutenant Colonel Owen Johnson III, the chief of plastic and reconstructive surgery at William Beaumont Army Medical Center in El Paso, Texas, harvested cartilage from Burrage’s ribs, carved it into the shape of an ear, and implanted it under the skin in her arm. There, it developed blood vessels, which Johnson says will allow Burrage to regain feeling in the ear once it’s healed. In an announcement released on Monday, Johnson called the operation a success.

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A computer programme modelled on the human brain learnt to navigate a virtual maze and take shortcuts, outperforming a flesh-and-blood expert, its developers said Wednesday.

While artificial intelligence (AI) programmes have recently made great strides in imitating human brain processing—everything from recognising objects to playing complicated board games—spatial navigation has remained a challenge.

Continue reading “Self-navigating AI learns to take shortcuts: study” »

Upcoming anti-viral medication for smallpox…

As bioterrorism fears grow, the first treatment for smallpox is nearing approval.

Called tecovirimat, the drug stops the variola virus, which causes smallpox, from sending out copies of itself and infecting other cells. “If the virus gets ahead of your immune system, you get sick,” says Dennis Hruby, the chief scientific officer of pharmaceutical company SIGA Technologies, which took part in developing the drug. “If you can slow the virus down, your immune system will get ahead.”

Continue reading “The first smallpox treatment is one step closer to FDA approval” »

Researchers from the Georgia Institute of Technology have built a flexible, wearable oral sodium sensor that could help monitor a person’s sodium intake.

A leading cause of hypertension is a person’s uncontrolled salt intake. This often results in high blood pressure and heart complications.

As a solution, the Georgia Institute of Technology researchers built the oral sodium sensor that could be easily worn in the mouth to monitor salt intake.

Continue reading “New Wearable Oral Sodium Sensor to Help Fight Hypertension” »