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[Burning Issue] CRISPR Technology and Associated Concerns

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The CRISPR-Cas9 system has revolutionized genetic manipulations and made gene editing simpler, faster and easily accessible to most laboratories.

To its recognition, this year, the French-American duo Emmanuelle Charpentier and Jennifer Doudna have been awarded the prestigious Nobel Prize for chemistry for CRISPR.

All-terrain microrobot flips through a live colon

A rectangular robot as tiny as a few human hairs can travel throughout a colon by doing back flips, Purdue University engineers have demonstrated in live animal models.

Why the back flips? Because the goal is to use these robots to transport drugs in humans, whose colons and other organs have . Side flips work, too.

Why a back-flipping robot to transport drugs? Getting a drug directly to its target site could remove side effects, such as hair loss or stomach bleeding, that the drug may otherwise cause by interacting with other organs along the way.

First Ebola therapy approved by the FDA

For the first time, an Ebola therapy has been approved for use. The Food and Drug Administration on Wednesday approved Inmazeb, an antibody cocktail made by Regeneron Pharmaceuticals.

With the approval, there are now both a vaccine — Merck’s Ervebo — and a therapeutic to battle Ebola Zaire, tools that for decades were out of reach for Ebola, which is one of the deadliest infections known to humankind. There is currently an outbreak in the Democratic Republic of the Congo, the third in the last three years in that country.

“This is the first time the FDA has approved a treatment specifically for Ebola, which has caused a number of deadly outbreaks,” said George Yancopoulos, Regeneron’s president and chief scientific officer, in a statement. “As we apply the same sophisticated technologies and manufacturing capabilities against COVID-19, we hope this will be one of many demonstrations of how the power of science can be successfully deployed against dangerous infectious diseases.”

A patient has died after ransomware hackers hit a German hospital

For the first time ever, a patient’s death has been linked directly to a cyberattack. Police have launched a “negligent homicide” investigation after ransomware disrupted emergency care at Düsseldorf University Hospital in Germany.

The victim: Prosecutors in Cologne say a female patient from Düsseldorf was scheduled to undergo critical care at the hospital when the September 9 attack disabled systems. When Düsseldorf could no longer provide care, she was transferred 19 miles (30 kilometers) away to another hospital. The hackers could be held responsible by German police, the BBC reports.

A tragic first: “If confirmed, this tragedy would be the first known case of a death directly linked to a cyberattack,” Ciaran Martin, formerly the chief executive of the UK’s National Cyber Security Centre, said in a speech at the Royal United Services Institute. “Although the purpose of ransomware is to make money, it stops systems working. So if you attack a hospital, then things like this are likely to happen. There were a few near misses across Europe earlier in the year, and this looks, sadly, like the worst might have come to pass.”

Rare horse cloned from cells taken from a stallion in 1980

Little Kurt looks like any other baby horse as he frolics playfully in his pen. He isn’t afraid to kick or head-butt an intruder who gets in his way and, when he’s hungry, dashes over to his mother for milk.

But 2-month-old Kurt differs from every other baby horse of his kind in one distinct way: He’s a clone.

The rare, endangered Przewalski’s horse was created from cells taken from a stallion that had sat frozen at the San Diego Zoo for 40 years before they were fused with an egg from a domestic horse.

High fructose intake may drive aggressive behaviors, ADHD, bipolar

The research, out today from the University of Colorado Anschutz Medical Campus and published in * Evolution and Human Behavior*, presents a hypothesis supporting a role for fructose, a component of sugar and high fructose corn syrup, and uric acid (a fructose metabolite), in increasing the risk for these behavioral disorders.

Johnson outlines research that shows a foraging response stimulates risk taking, impulsivity, novelty seeking, rapid decision making, and aggressiveness to aid the securing of food as a survival response. Overactivation of this process from excess sugar intake may cause impulsive behavior that could range from ADHD, to bipolar disorder or even aggression.” “Johnson notes, “We do not blame aggressive behavior on sugar, but rather note that it may be one contributor.”” “The identification of fructose as a risk factor does not negate the importance of genetic, familial, physical, emotional and environmental factors that shape mental health,” he adds.


Huh, want to know more.

“New research suggests that conditions such as attention deficit hyperactivity syndrome (ADHD), bipolar disorder, and even aggressive behaviors may be linked with sugar intake, and that it may have an evolutionary basis.

The research, out today from the University of Colorado Anschutz Medical Campus and published in Evolution and Human Behavior, presents a hypothesis supporting a role for fructose, a component of sugar and high fructose corn syrup, and uric acid (a fructose metabolite), in increasing the risk for these behavioral disorders.

“We present evidence that fructose, by lowering energy in cells, triggers a foraging response similar to what occurs in starvation,” said lead author Richard Johnson, MD, professor at the University of Colorado School of Medicine on the CU Anschutz Medical Campus.

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