Toggle light / dark theme

The project, led by Professor Zhiqin Chu from the Department of Electrical and Electronic Engineering at the University of Hong Kong (HKU), and Professor Qiang Wei from Sichuan University, utilized label-free quantum sensing technology to measure cellular force at the nanoscale. This advancement surpasses the limitations of traditional cellular force measurement tools and provides new insights into cellular mechanics, particularly regarding how cellular adhesion forces affect cancer cell spreading.

The research team has developed a new Quantum-Enhanced Diamond Molecular Tension Microscopy (QDMTM) that offers an effective approach for studying cell adhesion forces. Compared to cell force measurement methods that utilize fluorescent probes, QDMTM has the potential to overcome challenges such as photobleaching, limited sensitivity, and ambiguity in data interpretation. Furthermore, QDMTM sensors can be cleaned and reused, enhancing the absolute accuracy of comparing cell adhesion forces across various samples.

In Arizona, cases of valley fever — a disease spread by a fungus that lives in the dirt — have more than doubled in the past year, 12News reported. The spike in cases may be related to conditions brought about by the ongoing overheating of our planet, officials said.

Valley fever is a lung infection that causes symptoms similar to those that come with pneumonia. These symptoms include fatigue, cough, fever, headache, shortness of breath, night sweats, muscle aches, and rash, according to the Centers for Disease Control and Prevention.

Though more than 60% of people who are infected with valley fever do not get sick from it, in some cases the infection is severe enough that patients require hospitalization.

Acetic acid, also known as acetate, and other products that can be developed from acetic acid are used in a variety of industries, from food production to medicine to agriculture. Currently, acetate production uses a significant amount of energy and results in harmful waste products. The efficient and sustainable production of acetate is an important target for researchers interested in improving industrial sustainability.

A paper published in Carbon Future (“CO 2 electroreduction to acetate by enhanced tandem effects of surface intermediate over Co 3 O 4 supported polyaniline catalyst”) outlines a method using a polyaniline catalyst with cobalt oxide nanoparticles to produce acetate through carbon dioxide electroreduction.

This image shows a polyaniline catalyst coated in cobalt oxide nanoparticles and demonstrates how the catalyst facilitates the conversion of carbon dioxide to carbon monoxide to acetate. (Image: Carbon Future)

Worm-Derived Therapeutics For Debilitating Diseases — Dr. Andrea Choe, MD, Ph.D. — CEO, Holoclara Inc


Dr. Andrea Choe, MD, Ph.D. is the CEO and Co-Founder of Holoclara (https://www.holoclara.com/), a company focused on creating novel, safe, orally bioavailable worm-derived therapeutics with a focus on indications such as allergies and autoimmune disorders.

While pursuing her doctorate at the California Institute of Technology, Dr. Choe uncovered a unique pheromone language shared by roundworms that may have evolved over hundreds of millions of years.

The behavior of the cells that make up our blood vessels is crucial to our well-being. Conditions such as inflammation, oxygen deprivation and viral infection can stress these cells and disrupt the formation of new, often pathological, blood vessels. Now a team of researchers led by Jean-Philippe Gratton, chair of the Department of Pharmacology and Physiology at Université de Montréal and a specialist in vascular biology, has discovered a previously unknown pathway leading to the formation of new blood vessels, a process known as angiogenesis.

Furthermore, many experimental factors, such as fabrication errors and physical misalignments, can affect the performance of diffractive processors during the experimental deployment stage. Investigating the inherent robustness of different nonlinear encoding strategies to such imperfections, as well as their integration with vaccination-based training strategies39 or in situ training methods40, would provide more comprehensive guidance on the implementation and limitations of these approaches. These considerations would be crucial for future research and practical implementations of diffractive optical processors.

Throughout the manuscript, our analyses assumed that diffractive optical processors consist of several stacked diffractive layers interconnected through free-space light propagation, as commonly used in the literature10,13,41,42. Our forward model employs the angular spectrum method for light propagation, a broadly applicable technique known for its accuracy, covering all the propagating modes in free space. While our forward model does not account for multiple reflections between the diffractive layers, it is important to note that such cascaded reflections are much weaker than the transmitted light and, thus, have a negligible impact on the optimization process. This simplification does not compromise the model’s experimental validity since a given diffractive model also acts as a 3D filter for such undesired secondary sources that were ignored in the optimization process; stated differently, a by-product of the entire optimization process is that the resulting diffractive layers collectively filter out some of these undesired sources of secondary reflections, scattering them outside the output FOV. The foundation of our model has been extensively validated through various experiments10,11,16,18,43, providing a good match to the corresponding numerical model in each case, further supporting the accuracy of our forward model and diffractive processor design scheme.

Finally, our numerical analyses were conducted using coherent monochromatic light, which has many practical, real-world applications such as holographic microscopy and sensing, laser-based imaging systems, optical communications, and biomedical imaging. These applications, and many others, benefit from the precise control of the wave information carried by coherent light. In addition to coherent illumination, diffractive optical processors can also be designed to accommodate temporally and spatially incoherent illumination. By optimizing the layers for multiple wavelengths of illumination, a diffractive processor can be effectively designed to operate under broadband illumination conditions18,19,29,43,44,45,46,47. Similarly, by incorporating spatial incoherence into the forward model simulations, we can design diffractive processors that function effectively with spatially incoherent illumination30,48. Without loss of generality, our current study focuses on coherent monochromatic light to establish a foundational understanding of nonlinear encoding strategies in diffractive information processing using linear optical materials by leveraging the precise control that coherent processors offer. Future work could explore the extension of these principles to spatially or temporally incoherent illumination scenarios, further broadening the applicability of diffractive optical processors in practical settings.