Summary: Exposure to anesthesia causes lipid clusters to move from an ordered state to a disordered one, then back again. These changes lead to subsequent effects that cause changes in consciousness.
Source: Scripps Research Institute
Surgery would be inconceivable without general anesthesia, so it may come as a surprise that despite its 175-year history of medical use, doctors and scientists have been unable to explain how anesthetics temporarily render patients unconscious.
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SHOW NOTES TIME STAMPS:
0:00 Sneak Peak & Longevity Team Intro
2:08 Bill Faloon Intro: https://lifeextension.com & https://age-reversal.net
3:00 Life extension inspiration
3:35 Challenge death norm, …” I am not going to let that happen…”
4:39 Safety in life extension medication
4:58 Metformin Safety
6:58 “FDA is an incompetent and corrupt federal bureaucracy”
8:35 Berberine alternative for Metformin?
10:20 Metformin role in AMPK enzyme
11:30 AMPK activation in intermittent fasting?
12:00 Bill Faloon personal experience with Metformin
14:30 “…Take Care of yourself today…” by getting annual blood tests to test for lipids, glucose, etc.
15:05 Optimized sleep strategies
17:27 Insomnia
18:20 Blue light exposure graphic
18:50 Watch Brent’s interview with The Sleep Doctor, Micael Brues: https://youtube.com/watch?v=7af2AAjL4b4&t=662s
20:13 Removing anxiety strategies for better sleep
22:04 Human age reversal project clinical trial update
24:50 Exosomes — Watch Brent’s interview with Kimera Labs exosomes CEO/founder Dr. Duncan Ross: https://youtube.com/watch?v=X8eIxo3eqvQ&t=10s
26:30 IF NOTHING ELSE KILLS US, AGING WILL
27:15 Subscribe to The Church of Perpetual Life YouTube channel: https://www.youtube.com/COPL18
28:45 TAME trial for Metformin https://ncbi.nlm.nih.gov/pmc/articles/PMC5943638
29:58 Dr. Nir Barzilai
33:01 Metformin not illegal for doctors to prescribe
34:01 Intermittent fasting benefits
34:46 autophagy
35:59 Is coffee bad for telomeres?
37:01 All types of coffee containing roasted beans contain some acrylamide
37:28 Chlorophyllin to guard against acrylamide
37:55 Watch Brent’s interview with Bill Faloon https://youtube.com/watch?v=sKjHJE8x1bs
38:08 History and future of The Church Of Perpetual Life
40:20 Dr. Aubrey de Grey connected Bill Faloon with Neal Francis Vanderee to start The Church of Perpetual Life! Watch Brent’s interview with Aubrey https://youtube.com/watch?v=TquJyz7tGfk&t=365s
42:10 Religion and afterlife argument for life extension & immortality
43:35 Bill says Dr. George Church feels all viruses may just disappear in next 3–4 years and aging may be vanquished in next 10 years
44:10 Quantum Archeology “…Quantum computer technology that will ultimately be our road to physical immortality. “
45:23 Nikolai Fyodorov’s view of how “Mankind was created to find a way to achieve abundant immortality”
46:52 Why do you want to live forever?
49:01 Do the impossible!
51:00 How can all of us contribute to this life extension movement?
52:28 Why religion, immortality and living a long life are already connected
55:02 Simulation theory
55:45 Rate of how fast technology is improving
58:51 Diet food recommendations
1:00:03 Dr. Eric Berg YouTube: What Really Happens When We Fast? https://youtube.com/watch?v=vhmtoAYVRSo
1:01:42 Death anxiety
1:05:20 Bill Faloon’s influence on his kids and their work
1:09:01 Longevity benefits of having kids
1:09:48 fetal stem cells
1:11:13 Clinical trial update & where to get tested
1:13:34 Bill Faloon’s most important advice
1:15:30 Figure out your chronotype https://thepowerofwhenquiz.com
1:16:18 Brain health tips: Lithium, blueberries, CoQ10 (Ubiquinol)
1:18:55 Conclusion
To just solve a puzzle or play a game, artificial intelligence can require software running on thousands of computers. That could be the energy that three nuclear plants produce in one hour.
A team of engineers has created hardware that can learn skills using a type of AI that currently runs on software platforms. Sharing intelligence features between hardware and software would offset the energy needed for using AI in more advanced applications such as self-driving cars or discovering drugs.
“Software is taking on most of the challenges in AI. If you could incorporate intelligence into the circuit components in addition to what is happening in software, you could do things that simply cannot be done today,” said Shriram Ramanathan, a professor of materials engineering at Purdue University.
Circa 2017 face_with_colon_three
For the first time, scientists have found a genetic mutation that appears to offer a measure of protection against some of the biological effects of ageing.
And, as far as we know, it looks like the only community in the world known to harbour it is an Old Order Amish community living in Indiana.
The mutation can occur on one or both copies of a gene called SERPINE1. It’s known that when both gene copies are mutated, it can lead to a rare genetic bleeding disorder — and the Amish community in question is susceptible to it.
Since there is no treatment or vaccine for the novel coronavirus, or COVID-19 — the disease to which it leads — the only way to stop its spread is through social distancing and good hygiene. As such, long-term protective immunity could impact the overall course of the pandemic, the post-pandemic period and any subsequent waves. Until now, this concept has been a key component of the Health Ministry’s second wave strategy.
The Health Ministry recently revealed that it had purchased serological tests with the aim of surveying as many as 1 million people to determine how much of the public has been infected. Since around 80% of people who get the virus show little or no symptoms, they can carry and spread it without knowing.
However, “serology-based tests that measure previous infections for SARS‐CoV‐2 may have limited use if that infection has occurred more than one year prior to sampling,” the Amsterdam researchers explained.
It turns out that to hear a person yapping, you need a protein called Yap. Working as part of what is known as the Yap/Tead complex, this important protein sends signals to the hearing organ to attain the correct size during embryonic development, according to a new study published in the Proceedings of the National Academy of Sciences (PNAS) from the USC Stem Cell laboratory of Neil Segil.
In addition, the mice developed interstitial pneumonia, which affects the tissue and space around the air sacs of the lungs, causing the infiltration of inflammatory cells, the thickening of the structure that separates air sacs, and blood vessel damage. Compared with young mice, older mice showed more severe lung damage and increased production of signaling molecules called cytokines. Taken together, these features recapitulate those observed in COVID-19 patients.
When the researchers administered SARS-CoV-2 into the stomach, two of the three mice showed high levels of viral RNA in the trachea and lung. The S protein was also present in lung tissue, which showed signs of inflammation. According to the authors, these findings are consistent with the observation that patients with COVID-19 sometimes experience gastrointestinal symptoms such as diarrhea, abdominal pain, and vomiting. But 10 times the dose of SARS-CoV-2 was required to establish infection through the stomach than through the nose.
Future studies using this mouse model may shed light on how SARS-CoV-2 invades the brain and how the virus survives the gastrointestinal environment and invades the respiratory tract. “The hACE2 mice described in our manuscript provide a small animal model for understanding unexpected clinical manifestations of SARS-CoV-2 infection in humans,” concluded co-senior study author Chang-Fa Fan of NIFDC. “This model will also be valuable for testing vaccines and therapeutics to combat SARS-CoV-2.”
