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Category: biotech/medical – Page 2,009

The World’s Supply Chain Isn’t Ready for a Covid-19 Vaccine

The industries that shepherd goods around the world on ships, planes and trucks acknowledge they aren’t ready to handle the challenges of shipping an eventual Covid-19 vaccine from drugmakers to billions of people.

Already stretched thin by the pandemic, freight companies face problems ranging from shrinking capacity on container ships and cargo aircraft to a lack of visibility on when a vaccine will arrive. Shippers have struggled for years to reduce cumbersome paperwork and upgrade old technology that, unless addressed soon, will slow the relay race to transport fragile vials of medicine in unprecedented quantities.

Making a vaccine quickly is hard enough but distributing one worldwide offers a host of other variables, and conflicting forces may work against the effort: The infrastructure powering the global economy is scaling down for a protracted downturn just as pharmaceutical companies need to scale up for the biggest and most consequential product launch in modern history.

Microbiology – A Field Ripe for Entrepreneurship

Are you fascinated with microbiology? Have you ever thought about how to integrate your passion for research and entrepreneurship? The field of microbiology is expanding and being significantly impacted by advancements in technology. Recently, we interviewed Zack Abbott, Ph.D., who is the co-founder of ZBiotics. Zack explained his journey from studying infectious diseases to starting his own business focused on engineering bacteria for positive results. If you’ve ever wondered how you can be on the cutting edge of life sciences research, while working for yourself, read on about Zack’s experience.

1. Can you tell us a little bit about your background before entering the microbiology field?

I did my undergrad at UC Berkeley, where I double-majored in Molecular and Cell Biology and Classical History. I did not leave college thinking I would be a microbiologist. I wasn’t actually sure what I wanted to do, and so I tried out a few different jobs. Eventually, while gaining experience as a research assistant in an HIV lab at UC Davis, I realized that I would be happy with a career in infectious disease.

The Coronavirus Eviction Crisis

With the coronavirus raging across the world and the United States, I would to talk about one particular issue that is currently and will wreck havoc on the US: evictions due to the coronavirus and coronavirus-related unemployment.

Update: Turns out the federal government did have an eviction moratorium in the past. However, it ended a few days ago. Luckily, however, many in the government are thinking about extending the moratorium.

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New Photonic Crystal Light Converter: Powerful Tool for Observation in Physics and Life Sciences

Spectroscopy is the use of light to analyze physical objects and biological samples. Different kinds of light can provide different kinds of information. Vacuum ultraviolet light is useful as it can aid people in a broad range of research fields, but generation of that light has been difficult and expensive. Researchers created a new device to efficiently generate this special kind of light using an ultrathin film with nanoscale perforations.

The wavelengths of light you see with your eyes constitute a mere fraction of the possible wavelengths of light that exist. There’s infrared light which you can feel in the form of heat, or see if you happen to be a snake, that has a longer wavelength than visible light. At the opposite end is ultraviolet (UV) light which you can use to produce vitamin D in your skin, or see if you happen to be a bee. These and other forms of light have many uses in science.

Within the UV range is a subset of wavelengths known as vacuum ultraviolet light (VUV), so called because they are easily absorbed by air but can pass through a vacuum. Some VUV wavelengths in the region of around 120–200 nanometers (nm) are of particular use to scientists and medical researchers as they can be used for chemical and physical analyses of different materials and even biological samples.

Novel Drug Delivery Particles Use Neurotransmitters as a ‘Passport’ Into the Brain

Summary: Tufts researchers have developed neurotransmitter-lipid hybrids that help transport therapeutic drugs and gene editing proteins across the blood-brain barrier in mice.

Source: Tufts University

Biomedical engineers at the Tufts University School of Engineering have developed tiny lipid-based nanoparticles that incorporate neurotranmitters to help carry drugs, large molecules, and even gene editing proteins across the blood-brain barrier and into the brain in mice. The innovation, published today in Science Advances, could overcome many of the current limitations encountered in delivering therapeutics into the central nervous system, and opens up the possibility of using a wide range of therapeutics that would otherwise not have access to the brain.

Weekly reads: FDA news, goosebump stem cells, MSCs, autophagy

Ready for the latest recommended weekly reads in the world of stem cells and the regenerative medicine space including a bunch of important new FDA posts & changes?

This post has quite a lot on the FDA since it had a very big week with several new items of major importance to the cellular and regenerative medicine arena. I’ve linked to each announcement below with the agency’s title of the announcements. Underneath I provide some analysis and ask questions.

I’ve also included some other stem cell news and exciting papers too as usual, which I’ll start with here.

Reducing Sugar Uptake Increased Cancer Cells’ Sensitivity to Chemotherapy

People often talk about sugar intake and health 🤔

Researchers have successfully increased cancer cells’ sensitivity to chemotherapy to prevent glucose from entering the cancer cell.

Researchers at Lund University in Sweden have successfully increased cancer cells’ sensitivity to chemotherapy by preventing sugar uptake. Their study, “Targeting Glut1 In Acute Myeloid Leukemia To Overcome Cytarabine Resistance,” is published in Haematologica.

It is true that sugar feeds every cell in our body, even cancer cells. Researchers have long wondered if it would be possible to prevent glucose from entering the cancer cell and in that way increase the effect of chemotherapy.

To enable sugar molecules to enter the cancer cell through the cell membrane, the cell uses glucose transporters (GLUTs), which allow substances in and out. Researchers decided to study GLUT1 and its role in acute myeloid leukemia (AML).

Insufficient vitamin D increases risk of severe COVID-19, says new study

Low levels of vitamin D may put people at risk for developing COVID-19, a new study by לאומית שירותי בריאות and the Azrieli Faculty of Medicine of Bar-Ilan University.

Vitamin D has long been understood to impact immune response. According to Dr. Milana Frenkel-Morgenstern, leader of the Azrieli Faculty of Medicine research group, as much as 70% of the adult population worldwide is vitamin D insufficient or deficient.

The Leumit and Bar-Ilan scientists analyzed if the risk of developing COVID-19 or becoming hospitalized because of it increases for people who have a low level of vitamin D.

They studied 782 Israeli COVID-19-positive patients and 7,825 negative patients and determined that a low plasma vitamin D level appears to be an independent risk factor for COVID-19 infection and hospitalization.

“We don’t know the mechanism,” Frenkel-Morgenstern said. “What we do know is that people who develop severe COVID and were hospitalized – these people have significantly low vitamin D levels.”

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