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Archive for the ‘biotech/medical’ category: Page 1986

Sep 10, 2019

Chicken study reveals that environmental factors, not just chance, could drive species evolution

Posted by in categories: biotech/medical, evolution, genetics

In the version of evolutionary theory most of us are familiar with, randomly occurring variation in traits, caused by mutations in our DNA, can be fixed in a population through natural selection. However, writing in Epigenetics journal, a team of Swedish researchers from Linköping University suggests that mutations that can be caused by environmental changes, not just random chance, might be responsible for species diversity.

Until quite recently, it was assumed that DNA causing new gene variations occurred more or less randomly. While random mutations do occur, recent research has shown that can be altered by environmental influences too. According to a study published in Epigenetics journal, a particular type of mutation, linked to , has, over time, led to new animal breeds—and could be responsible for whole new species.

Sep 10, 2019

Stem Cells From Baby Teeth Could Be Used To Fix Dental Injuries

Posted by in category: biotech/medical

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Sep 10, 2019

Honey With Turmeric The Most Potent Antibiotic That Not Even Doctors Can Explain

Posted by in categories: biotech/medical, health, neuroscience

The amazing properties and unique flavor of turmeric have been valued and used for centuries. This incredibly healthy deep-yellow spice offers a myriad of medicinal qualities, and is commonly used in the Chinese, Indian and Ayurvedic medicine. health, medicine, science, health, medicine, science, health, medicine, science, health, science.

People have used turmeric in the treatment of wounds and cuts, skin issues, muscle sprains, liver diseases, respiratory issues, and gastric issues, as well as digestive problems, inflammations, infections, and malignant tumors.

Its active ingredient, curcumin, provides powerful antimicrobial, anti-inflammatory, and antioxidant properties. Turmeric effectively fights inflammation in the body, osteoarthritis, gastritis, microbes, gastric and peptic ulcers, improves the function of the brain and treats Alzheimer’s disease, and helps in the case of countless other health issues. health, medicine, science, health, medicine, science, health, medicine, science, health, science.

Sep 10, 2019

Prolonged antibiotic treatment may alter preterm infants’ microbiome

Posted by in category: biotech/medical

NIH-funded research finds evidence of antibiotic-resistant gut bacteria.

Sep 10, 2019

You are not gluten intolerant, you are glyphosate intolerant

Posted by in category: biotech/medical

Study blames Roundup herbicide for gluten intolerance and celiac disease epidemic.

Sep 10, 2019

Researchers link specific enzyme to process of metabolic dysfunction in aging

Posted by in categories: biotech/medical, life extension

Researchers at Mayo Clinic have identified the enzyme, called CD38, that is responsible for the decrease in nicotinamide adenine dinucleotide (NAD) during aging, a process that is associated with age-related metabolic decline. Results demonstrated an increase in the presence of CD38 with aging in both mice and humans. The results appear today in Cell Metabolism.

“As we age, we experience a decline in our metabolism and . This increases the incidence of age-related metabolic diseases like obesity, diabetes and others,” says Eduardo Chini, M.D., Ph.D., anesthesiologist and researcher for Mayo Clinic’s Robert and Arlene Kogod Center on Aging and lead author of the study. “Previous studies have shown that levels of NAD decline during the aging process in several organisms. This decrease in NAD appears to be, at least in part, responsible for age-related metabolic decline.”

In this study, at the Center on Aging have shown that CD38, an enzyme that is present in inflammatory cells, is directly involved in the process that mediates the age-related NAD decline. Comparing 3- to 32-month-old mice, researchers found that levels of CD38 increased at least two to three times during chronological aging in all tissues tested, including the liver, fat, spleen and .

Sep 10, 2019

Be the first to comment on “Warning: Hidden Danger From Pet Dogs Discovered”

Posted by in categories: biotech/medical, education

Researchers at the Universities of Abuja and Nigeria, in collaboration with the University of Bristol, have detected a potentially human-infective microbe in pet dogs in Nigeria.

Dogs in tropical Africa run the risk of contracting canine trypanosomosis if they are bitten by bloodsucking tsetse flies carrying trypanosomes – microscopic, single-celled organisms found in the bloodstream. In dogs, this disease runs a severe course and is often fatal; “white eyes” or corneal cloudiness is one of the characteristic and obvious signs of the disease.

Sick dogs suspected of trypanosomosis are frequently brought to the University of Nigeria Veterinary Teaching Hospital (UNVTH) in Nsukka, where diagnosis relies on examination of a blood smear under the microscope. While trypanosomes are easily detected by their rapid motion among the blood cells, it is hard to determine the exact species of trypanosome by microscopy alone.

Sep 10, 2019

Copy cats: pet-cloning in China – in pictures

Posted by in category: biotech/medical

Pet cloning is illegal in many countries but approved in several states including South Korea and the US, where the singer Barbra Streisand announced last year she had cloned her dog. The first significant success in animal cloning was Dolly the sheep, born in Britain in 1996 as the first mammal cloned from an adult cell. In 2005, researchers in South Korea cloned the first dog.


As Chinese spending on pets increases by up to 27% year on year, a Beijing firm has created its first cloned kitten

AFP/Getty.

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Sep 9, 2019

World’s smallest accelerometer points to new era in wearables, gaming

Posted by in categories: biotech/medical, nanotechnology, wearables

In what could be a breakthrough for body sensor and navigation technologies, researchers at KTH have developed the smallest accelerometer yet reported, using the highly conductive nanomaterial, graphene.

Each passing day, nanotechnology and the potential for material make new progress. The latest step forward is a tiny made with graphene by an international research team involving KTH Royal Institute of Technology, RWTH Aachen University and Research Institute AMO GmbH, Aachen.

Among the conceivable applications are monitoring systems for cardiovascular diseases and ultra-sensitive wearable and portable motion-capture technologies.

Sep 9, 2019

Genome engineering with CRISPR/HDR to diversify the functions of hybridoma-produced antibodies

Posted by in categories: bioengineering, biotech/medical, genetics, life extension

Bioengineers and life scientists incorporate hybridoma technology to produce large numbers of identical antibodies, and develop new antibody therapeutics and diagnostics. Recent preclinical and clinical studies on the technology highlight the importance of antibody isotypes for therapeutic efficacy. In a new study, a research team in Netherlands have developed a versatile Clustered Regularly Interspaced Short Palindrome Repeats (CRISPR) and homology directed repair (HDR) platform to rapidly engineer immunoglobin domains and form recombinant hybridomas that secrete designer antibodies of a preferred format, species or isotype. In the study, Johan M. S. van der Schoot and colleagues at the interdisciplinary departments of immunology, proteomics, immunohematology, translational immunology and medical oncology, used the platform to form recombinant hybridomas, chimeras and mutants. The stable antibody products retained their antigen specificity. The research team believes the versatile platform will facilitate mass-scale antibody engineering for the scientific community to empower preclinical antibody research. The work is now published on Science Advances.

Monoclonal antibodies (mAb) have revolutionized the medical field with applications to treat diseases that were once deemed incurable. Hybridoma technology is widely used since 1975 for mAb discovery, screening and production, as immortal cell lines that can produce large quantities of mAbs for new antibody-based therapies. Scientists had generated, validated and facilitated a large number of hybridomas in the past decade for preclinical research, where the mAb format and isotypes were important to understand their performance in preclinical models. Genetically engineered mAbs are typically produced with recombinant technology, where the variable domains should be sequenced, cloned into plasmids and expressed in transient systems. These processes are time-consuming, challenging and expensive, leading to outsourced work at contract research companies, which hamper the process of academic early-stage antibody development and preclinical research.

In its mechanism of action, the constant antibody domains forming the fragment crystallizable – (Fc) domain are central to the therapeutic efficacy of mAbs since they engage with specific Fc receptors (FcRs). Preceding research work had highlighted the central role of Fc in antibody-based therapeutics to emphasize this role. Since its advent, CRISPR and associated protein Cas-9 (CRISPR-Cas9)-targeted genome editing technology has opened multitudes of exciting opportunities for gene therapy, immunotherapy and bioengineering. Researchers had used CRISPR-Cas9 to modulate mAb expression in hybridomas, generate a hybridoma platform and engineer hybridomas to introduce antibody modification. However, a platform for versatile and effective Fc substitution from foreign species within hybridomas with constant domains remains to be genetically engineered.