Lifeboat Foundation

A team of Australian researchers has designed a reliable strategy for testing physical abilities of humanoid robots—robots that resemble the human body shape in their build and design. Using a blend of machine learning methods and algorithms, the research team succeeded in enabling test robots to effectively react to unknown changes in the simulated environment, improving their odds of functioning in the real world.

The findings, which were published in a joint publication of the IEEE and the Chinese Association of Automation Journal of Automatica Sinica in July, have promising implications in the broad use of humanoid robots in fields such as healthcare, education, disaster response and entertainment.

“Humanoid robots have the ability to move around in many ways and thereby imitate human motions to complete complex tasks. In order to be able to do that, their stability is essential, especially under dynamic and unpredictable conditions,” said corresponding author Dacheng Tao, Professor and ARC Laureate Fellow in the School of Computer Science and the Faculty of Engineering at the University of Sydney.

Wearing a flower brooch that blooms before your eyes sounds like magic. KAIST researchers have made it real with robotic muscles.

Researchers have developed an ultrathin, artificial muscle for soft robotics. The advancement, recently reported in the journal Science Robotics, was demonstrated with a robotic blooming flower brooch, dancing robotic butterflies and fluttering tree leaves on a kinetic art piece.

The robotic equivalent of a muscle that can move is called an actuator. The actuator expands, contracts or rotates like muscle fibers using a stimulus such as electricity. Engineers around the world are striving to develop more dynamic actuators that respond quickly, can bend without breaking, and are very durable. Soft, robotic muscles could have a wide variety of applications, from wearable electronics to advanced prosthetics.

A deadly outbreak of “superbug” salmonella sprung up in the US late last year. While this is certainly not the first time drug-resistant bugs have been found in the US, the outbreak marks yet another milestone on the road to a future without antibiotics.

Over 250 people across 32 states fell sick with a strain of Salmonella that’s resistant to multiple antibiotics between June 2018 and March 2019, according to a recent Morbidity and Mortality Weekly Report from the US Centers for Disease Control and Prevention (CDC). At least two people died from the infection, and a further 60 cases were so severe that they required hospitalization.

The outbreak of antibiotic-resistant Salmonella infections was linked back to beef bought in the US and a “Mexican-style soft cheese” obtained in Mexico. They found that the strain didn’t respond to ciprofloxacin and had “decreased susceptibility” to azithromycin, two of the main antibiotic drugs used to treat Salmonella infections. The unusual strain – known as Salmonella enterica serotype Newport – emerged no later than 2016 and is still continuing to spread among cattle.

In normal vision, light falls on the retinas inside the eyes, and is immediately transduced into electrochemical signals before being uploaded to the brain through the optic nerves. So you do not see light itself, but the brain’s interpretation of electrochemical signals in the visual parts of the brain. It follows that, if your eyes do not work, but your brain is stimulated just so, your visual neurons will activate (and you will be able to see) just the same as if your eyes were in perfect condition.

Sounds easy, but can we do that? Building on decades of research in visual neuroscience, my lab, in collaboration with Susana Martinez-Conde’s, has now conducted some of the studies that validate this idea, completing some of the most important preliminary steps towards a new kind of visual prosthetic.

Francis Collins, the Director of the National Institutes of Health, has just posted a blog that highlights our approach. He took notice of our work when we first presented it at this year’s meeting for the Principal Investigators of the BRAIN Initiative—the NIH led government funding initiative meant to spur research along on topics like brain implants. The BRAIN Initiative funds several agencies including the NIH, including the National Science Foundation, who kindly funded the grant driving our research thus far.

SAN ANTONIO — Sleep-disordered breathing (SDB), and the disruption in nightly sleep it causes, speeds up the aging process, according to preliminary research.

SDB is a common disorder that results in oxidative stress and inflammation and is associated with several age-related health disorders. However, it hasn’t been well studied with respect to epigenetic aging.

“To our knowledge, this study is the first empirical study that has linked sleep-disordered breathing with epigenetic age acceleration,” Xiaoyu Li, ScD, of Brigham and Women’s Hospital and Harvard Medical School in Boston, Massachusetts, told Medscape Medical News.

Is an American biochemist and cell biologist. She is a professor of biogerontology at the Buck Institute for Research on Aging. She is also a member of the SENS Research Foundation Advisory Board and an adviser at the Lifeboat Foundation. She is co-editor in chief of the Aging Journal, together with Mikhail Blagosklonny and David Sinclair, and founder of the pharmaceutical company Unity Biotechnology. She is listed in Who’s Who in Gerontology.

She is widely known for her research on how senescent cells influence aging and cancer — in particular the senescence-associated secretory phenotype (SASP).

Continue reading “Judith Campisi — Senolytics for Healthy Aging” »

Exceptional longevity: the hunt for associated factors has concentrated on #genomics and biomarkers. What has been missed? Optimism. And it’s dose-dependent.

Researchers from Boston University School of Medicine (BUSM), National Center for PTSD at VA Boston Healthcare System and Harvard T.H. Chan School of Public Health, have found that individuals with greater optimism are more likely to live longer and to achieve “exceptional longevity,” that is, living to age 85 or older.

Optimism refers to a general expectation that good things will happen, or believing that the future will be favorable because we can control important outcomes. Whereas research has identified many risk factors that increase the likelihood of diseases and premature death, much less is known about positive psychosocial factors that can promote healthy aging.

Continue reading “New evidence that optimists live longer” »

A gene called Lipocalin 2 is a major culprit in triple-negative breast cancer, an aggressive form of the disease for which there are few effective, targeted treatments. A team of researchers at Boston Children’s Hospital has developed an innovative way to knock out the gene using the editing system CRISPR and has shown its potential for treating triple-negative breast tumors in mice.

But to make CRISPR work in breast tumors, the researchers had to figure out a way to deliver the technology into breast cancer cells without using a virus or something else that might cause off-target side effects. So they encapsulated it in nanoparticles and targeted it at ICAM-1, a molecule expressed on breast cancer cells.

The encapsulated CRISPR system knocked out Lipocalin 2 with 81% efficiency in tumor samples, and when injected into mouse models of triple-negative breast cancer, it slowed tumor growth by 77%. The researchers reported the results in the journal Proceedings of the National Academy of Sciences.

The journal club will be returning on 27th August with your host Dr. Oliver Medvedik and special guest Alexander Tyshkovskiy, a Ph.D. student who works at the Gladyshev Lab at Brigham and Women’s Hospital, Harvard Medical School, Boston. The topic for the journal club this month will be the recent paper, “Identification and Application of Gene Expression Signatures Associated with Lifespan Extension” published in Cell Metabolism. This study is Alexander Tyshkovskiys project and forms part of his Ph.D. so we are fortunate to have him joining us on the show to talk us through this fascinating study.

Sci-Hub link here: https://sci-hub.tw/https://www.sciencedirect.com/science/art…3119303729