Lifeboat Foundation

Dubbed ‘antibiotic apocalypse’, the antibiotic resistant superbugs have become a massive cause for concern for health professionals as their numbers continue to rise. Such is the worry around antibiotic superbugs that experts believe that they will claim 10 million lives by 2050, with 700,000 people dying a year after catching the infections, according to a recent report from the American Chemical Society’s Enviromental Science and Technology Journal. Humans, especially in the West, have become so reliant on antibiotics to help cure illnesses that many of the bacteria that they are trying to fight have become resistant to the drugs through evolution.

Chemotherapy works off of a basic premise: kill all rapidly-growing cells in an effort to wipe out tumor cells. The tactic, while generally effective, has quite a few off-target casualties, including cells that produce hair and cells that line the stomach.

Scientists have tried to skirt the problem by creating missile-like drugs that zero in on cancer cells specifically, sparing healthy cells.

These missile-like drugs, known as antibody-drug conjugates (ADCs), have been in the works for decades, but only in recent years have they made it to clinical trials, Kimberly Tsui, a genetics graduate student, told me.

Industry declares that it will not make DNA changes affecting future generations.

We learn from our personal interaction with the world, and our memories of those experiences help guide our behaviors. Experience and memory are inexorably linked, or at least they seemed to be before a recent report on the formation of completely artificial memories. Using laboratory animals, investigators reverse engineered a specific natural memory by mapped the brain circuits underlying its formation. They then “trained” another animal by stimulating brain cells in the pattern of the natural memory. Doing so created an artificial memory that was retained and recalled in a manner indistinguishable from a natural one.

Memories are essential to the sense of identity that emerges from the narrative of personal experience. This study is remarkable because it demonstrates that by manipulating specific circuits in the brain, memories can be separated from that narrative and formed in the complete absence of real experience. The work shows that brain circuits that normally respond to specific experiences can be artificially stimulated and linked together in an artificial memory. That memory can be elicited by the appropriate sensory cues in the real environment. The research provides some fundamental understanding of how memories are formed in the brain and is part of a burgeoning science of memory manipulation that includes the transfer, prosthetic enhancement and erasure of memory. These efforts could have a tremendous impact on a wide range of individuals, from those struggling with memory impairments to those enduring traumatic memories, and they also have broad social and ethical implications.

In the recent study, the natural memory was formed by training mice to associate a specific odor (cherry blossoms) with a foot shock, which they learned to avoid by passing down a rectangular test chamber to another end that was infused with a different odor (caraway). The caraway scent came from a chemical called carvone, while the cherry blossom scent came from another chemical, acetophenone. The researchers found that acetophenone activates a specific type of receptor on a discrete type of olfactory sensory nerve cell.

Saying goodbye to the warm summer months is a little easier when it also means the war against mosquito bites is coming to an end. They’re not just an itchy annoyance, however, mosquitoes can spread dangerous diseases and viruses, but researchers at Brown University might have come up with the perfect mosquito forcefield: garments lined with graphene.

Today, thanks to remarkable advances in antiretroviral drugs, most people with the human immunodeficiency virus (HIV) can expect to live an almost normal lifespan. But that means staying on medications for life. If those are stopped, HIV comes roaring back in just weeks. Finding a permanent cure for HIV infection, where the virus is completely and permanently eliminated from the body, has proven much tougher. So, I’m encouraged by recent work that shows it may be possible to eliminate HIV in a mouse model, and perhaps—with continued progress—someday we will actually cure HIV in humans.

This innovative approach relies on a one-two punch: drugs and genetic editing. First, HIV-infected mice received an experimental, long-acting form of antiretroviral therapy (ART) that suppresses viral replication. This step cleared the active HIV infection. But more was needed because HIV can “hide” by inserting its DNA into its host’s chromosomes—lying dormant until conditions are right for viral replication. To get at this infectious reservoir, researchers infused the mice with a gene-editing system designed to snip out any HIV DNA still lurking in the genomes of their spleen, bone marrow, lymph nodes, and other cells. The result? Researchers detected no signs of HIV in more than one-third of mice that received the combination treatment.

The new study in Nature Communications is the product of a collaboration between the NIH-funded labs of Howard Gendelman, University of Nebraska Medical Center, Omaha, and Kamel Khalili, Temple University, Philadelphia [1]. A virologist by training, Khalili years ago realized that HIV’s ability to integrate into the genomes of its host’s cells meant that the disease couldn’t be thought of only as a typical viral infection. It had a genetic component too, suggesting that an HIV cure might require a genetic answer.

How about some life extension optimism to start your day?

People 50 and older have a lot to look forward to, according to Juvenescence’s Greg Bailey—mainly that we won’t be aging as fast or poorly as our parents. “Science fiction has become science,” said the UK-based anti-aging biotech’s CEO about the company’s completing its $100 million Series B round of financing last week. “I think the world is going to be shocked,” he said in an interview. In total, Juvenescence has now raised $165 million in just 18 months to fund longevity projects with the lofty goal of extending human lifespans to 150 years.

A little bit of norovirus—the highly infectious microbe that causes about 20 million cases of food poisoning in the United States each year—goes a long way. Just 10 particles of the virus can cause illness in humans. A team of University of Arizona researchers has created a simple, portable and inexpensive method for detecting extremely low levels of norovirus.

Jeong-Yeol Yoon, a researcher in the Department of Biomedical Engineering; Soo Chung, a biosystems engineering doctoral student who works in Yoon’s Biosensors Lab; and Kelly A. Reynolds, Chair of the Department of Community, Environment and Policy in the Mel & Enid Zuckerman College of Public Health, led the project. The team published their results in ACS Omega, the official journal of the American Chemical Society, and Yoon is presenting the research at the ACS Fall 2019 National Meeting & Exposition in San Diego this week.

Continue reading “Using a smartphone to detect norovirus” »

Unaffected areas of the Rocky Mountain Arsenal National Wildlife Refuge opened on Saturday, August 17.

Numerous sites with plague-infected fleas affecting local prairie dog colonies will remain closed through Labor Day Weekend so that authorities can continue to treat the prairie dogs’ holes with insecticide to kill any remaining fleas that could transmit the disease to prairie dogs, people, and pets.

The Rocky Mountain Arsenal National Wildlife Refuge will reopen to visitors on Saturday, August 17, including the refuge’s Visitor Center, Wildlife Drive, and recreational fishing access. Some trails and parking lots will remain closed through Labor Day weekend due to ongoing monitoring and plague management efforts. These areas are clearly marked and will reopen to visitors in early September. For up-to-date information about visitor access and activities, please visit www.fws.gov/refuge/rocky_mountain_arsenal.