Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 1930

A new proof-of-concept study has found a combination of two drugs, already approved by the FDA for other uses, may boost the release of stem cells from bone marrow and accelerate the healing of broken bones. Only demonstrated in animals at this stage, the researchers suggest clinical trials could progress rapidly considering the drugs have already been demonstrated as safe in humans.

“The body repairs itself all the time,” says corresponding author on the study Sara Rankin. “We know that when bones break they will heal, and this requires the activation of stem cells in the bone. However, when the damage is severe, there are limits to what the body can do of its own accord.”

A great deal of current research is focusing on mesenchymal stem cell (MSC) therapies. MSCs are a type of adult stem cell that can grow into a variety of different cell types including muscle, fat or bone. Many current MSC treatments in development involve extracting a small number from a patient, growing them in laboratory conditions, then injecting them back into the patient.

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Dev Genes Evol. 2012 Mar;222:29–44. doi: 10.1007/s00427-011‑0387-z. Epub 2012 Feb 23.

Gap junctional proteins are important components of signaling pathways required for the development and ongoing functions of all animal tissues, particularly the nervous system, where they function in the intracellular and extracellular exchange of small signaling factors and ions. In animals whose genomes have been sufficiently sequenced, large families of these proteins, connexins, pannexins, and innexins, have been found, with 25 innexins in the nematode Caenorhabditis elegans Starich et al. (Cell Commun Adhes 8: 311–314, 2001) and at least 37 connexins in the zebrafish Danio rerio Cruciani and Mikalsen (Biol Chem 388:253–264, 2009). Having recently sequenced the medicinal leech Hirudo verbana genome, we now report the presence of 21 innexin genes in this species, nine more than we had previously reported from the analysis of an EST-derived transcriptomic database Dykes and Macagno (Dev Genes Evol 216: 185–97, 2006); Macagno et al. (BMC Genomics 25:407, 2010).

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Optical technologies that can be used to modulate neuronal activity are opening up exciting possibilities for research in neuroscience and biology. Optical tools allow neuroscientists to excite and inhibit neurons or areas of the brain at will. They can thus be used to investigate the function of specific brain circuits or regions, as well as to identify new potential treatments for neurological and psychiatric diseases.

The generation of tethered azobenzene photoswitches targeted at bilayers or linked to is a pioneering optical technique that could further aid the study of the human brain. This technique, however, particularly when implemented at high light intensities, can lead to a considerable increase in temperature and can thus be harmful to neurons when used repeatedly.

To overcome this limitation, researchers at the Italian Institute of Technology (IIT) in collaboration with Politecnico di Milano, have recently created a new light-sensitive azobenzene compound, dubbed Ziapin2, which can be used to build photoswitches that do not increase in temperature when irradiated with visible light. This new compound, introduced in a paper published in Nature Nanotechnology, partitions into the with a high stability, enabling its thinning and an increased capacitance at a steady state.

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I’ve been reading an excellent book by David Wood, entitled, which was recommended by my pal Steele Hawes. I’ve come to an excellent segment of the book that I will quote now.

“One particular challenge that international trustable monitoring needs to address is the risk of more ever powerful weapon systems being placed under autonomous control by AI systems. New weapons systems, such as swarms of miniature drones, increasingly change their configuration at speeds faster than human reactions can follow. This will lead to increased pressures to transfer control of these systems, at critical moments, from human overseers to AI algorithms. Each individual step along the journey from total human oversight to minimal human oversight might be justified, on grounds of a balance of risk and reward. However, that series of individual decisions adds up to an overall change that is highly dangerous, given the potential for unforeseen defects or design flaws in the AI algorithms being used.”

The fifteen years from 2020 to 2035 could be the most turbulent of human history. Revolutions are gathering pace in four overlapping fields of technology: nanotech, biotech, infotech, and cognotech, or NBIC for short. In combination, these NBIC revolutions offer enormous new possibilities: enormous opportunities and enormous risks.

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Department of Homeland Security (DHS) whistleblower Philip Haney was found dead in Amador County, Calif., on Friday, according to local authorities.

Haney, 66, “appeared to have suffered a single, self-inflicted gunshot wound,” the Amador County Sheriff’s Office said in a release. Sheriff and coroner Martin A. Ryan shared the initial details of the case.

“On February 21, 2020 at approximately 1012 hours, deputies and detectives responded to the area of Highway 124 and Highway 16 in Plymouth to the report of a male subject on the ground with a gunshot wound,” the release read.

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“Science hasn’t yet found a way to make complex animals like dogs live forever, so the next best thing we can do is find a way to maintain health for as long as possible during the aging process,” said Church.

And the goal was for this to hit a market and use the income to pay for human trials lasting 10 years.

Combination gene therapy developed at Wyss Institute and Harvard Medical School treats four age-related conditions.

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