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Category: biotech/medical – Page 1,932

Circa 2017

Insulin-producing cells have been restored in mouse models of type 1 diabetes using a new genetic engineering technique.

American scientists adapted the gene editing technology known as CRISPR (clustered, regularly interspaced, short palindromic repeat) to successfully treat mouse models of type 1 diabetes, kidney disease and muscular dystrophy.

CRISPR enables scientists to edit the genetic material of an organism allowing for DNA sequences to be easily altered and gene function to be modified.

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SEOUL, South Korea (AP) — A barrage of North Korean missiles fired from both the ground and fighter jets splashed down on the waters off the country’s east coast on Tuesday, South Korea’s military said, a show of force on the eve of a key state anniversary in the North and parliamentary elections in the rival South.

The back-to-back launches were the latest in a series of weapons tests that North Korea has conducted in recent weeks amid stalled nuclear talks and outside worries about a possible coronavirus outbreak in the country.

North Korean troops based in the eastern coastal city of Munchon first launched several projectiles — presumed to be cruise missiles — on Tuesday morning, South Korea’s Joint Chiefs of Staff said in a statement.

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The paranasal sinuses are major producers of nitric oxide (NO). We hypothesized that oscillating airflow produced by humming would enhance sinus ventilation and thereby increase nasal NO levels. Ten healthy subjects took part in the study. Nasal NO was measured with a chemiluminescence technique during humming and quiet single-breath exhalations at a fixed flow rate. NO increased 15-fold during humming compared with quiet exhalation. In a two-compartment model of the nose and sinus, oscillating airflow caused a dramatic increase in gas exchange between the cavities. Obstruction of the sinus ostium is a central event in the pathogenesis of sinusitis. Nasal NO measurements during humming may be a useful noninvasive test of sinus NO production and ostial patency. In addition, any therapeutic effects of the improved sinus ventilation caused by humming should be investigated.

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The company’s update on its development of COVID-19 drug candidate is promising.

Vancouver, British Columbia—(Newsfile Corp. — March 31, 2020) — NanoViricides, Inc. (NYSE American: NNVC) (the “Company”) is a nano-biopharmaceutical Company at the development stage, with proprietary and patented drug development work focused on viral diseases. The Company’s research involves the use of a unique nanomedicine technology called nanoviricides — agents designed to “fool” a virus into attaching to an antiviral nanomachine, in the same way that the virus normally attaches to the receptors on a cell surface, but for the purpose of its neutralization and destruction. NanoViricides was highlighted by SmallCapsDaily for providing an update on its progress to develop a drug that can treat COVID-19, the coronaviral pneumonia disease which is caused by the SARS-CoV-2 virus, aka, 2019-nCoV, also known as the Wuhan coronavirus.

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Step two of…

(Meanwhile in Bangladesh)

The ID2020 Alliance has launched a new digital identity program at its annual summit in New York, in collaboration with the Government of Bangladesh, vaccine alliance Gavi, and new partners in government, academia, and humanitarian relief.

The program to leverage immunization as an opportunity to establish digital identity was unveiled by ID2020 in partnership with the Bangladesh Government’s Access to Information (a2i) Program, the Directorate General of Health Services, and Gavi, according to the announcement.

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Shane chats with former NSA spy and whistleblower Edward Snowden on the rise of authoritarianism during the COVID-19 pandemic.

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The role of automatic electrocardiogram (ECG) analysis in clinical practice is limited by the accuracy of existing models. Deep Neural Networks (DNNs) are models composed of stacked transformations that learn tasks by examples. This technology has recently achieved striking success in a variety of task and there are great expectations on how it might improve clinical practice. Here we present a DNN model trained in a dataset with more than 2 million labeled exams analyzed by the Telehealth Network of Minas Gerais and collected under the scope of the CODE (Clinical Outcomes in Digital Electrocardiology) study. The DNN outperform cardiology resident medical doctors in recognizing 6 types of abnormalities in 12-lead ECG recordings, with F1 scores above 80% and specificity over 99%. These results indicate ECG analysis based on DNNs, previously studied in a single-lead setup, generalizes well to 12-lead exams, taking the technology closer to the standard clinical practice.

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