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Category: biotech/medical – Page 1,867

RNA-binding proteins in human genetic disease

RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their malfunction underlies the origin of many diseases. RBPs can recognize hundreds of transcripts and form extensive regulatory networks that help to maintain cell homeostasis. System-wide unbiased identification of RBPs has increased the number of recognized RBPs into the four-digit range and revealed new paradigms: from the prevalence of structurally disordered RNA-binding regions with roles in the formation of membraneless organelles to unsuspected and potentially pervasive connections between intermediary metabolism and RNA regulation. Together with an increasingly detailed understanding of molecular mechanisms of RBP function, these insights are facilitating the development of new therapies to treat malignancies. Here, we provide an overview of RBPs involved in human genetic disorders, both Mendelian and somatic, and discuss emerging aspects in the field with emphasis on molecular mechanisms of disease and therapeutic interventions.

Space or Earth? Both!

While we are opening our preliminary discussion for the 3rd SRI World Congress, a number of questions and concerns are being expressed by the main space columnists, about what could be the philosophic setup of the space policy defined by the new US Administration, should it be confirmed the next December 14th. Though Joe Biden didn’t yet say very much about space policy, the most accredited plans foresee cuts to the budget of NASA’s manned space flight programs, in order to give more fuel to the observation of Earth, climate change, and environmental issues.

We are not against raising the budget to Earth observation programs, which are much needed in the current climatic and environmental situation. Besides Earth observation, space agencies should also begin considering the use of space technologies to mitigate the effects of the climate change and the environmental issues, i.e. active space strategies targeted to control the Earth climate.

However, the most important point to be duly focused is that the same priority granted to environmental space programs should be given to bootstrapping the geo-lunar space region settlement and industrialization. Space development is the primary strategy against the awful multi-crisis that is striking our globalized civilization: pandemics, economic, climatic-environmental, resource conflicts, migrations, unemployment.

HDL: What’s Optimal For Minimizing Disease Risk And Maximizing Longevity?

Here’s my latest video!

Meta-analysis for the association between HDL with all-cause mortality risk has identified HDL levels 55 — 60 mg/dL range as optimal. However, that data includes subjects up to 85y-in the video, I present data for 85y — 115yr olds that additionally suggests HDL in the 55 — 60 mg/dL range as optimal. In addition, I show my own HDL data over the past 15 years (n=34), the correlation for HDL with my diet, and how I plan on consistently increasing my 15-year average HDL of ~44 mg/dL to the 50’s.

Connecticut coronavirus update

I found this news while researching on hyperbaric oxygen therapy. A lot of news on it now. 😃

GREENWICH, Connecticut (WABC) — A hospital in Connecticut is one of six nationwide treating COVID-19 with hyperbaric oxygen therapy, which officials say is emerging as an effective way to deliver oxygen to coronavirus patients.

Greenwich Hospital is part of a yearlong trial to treat 600 patients with the therapy, best known for treating scuba divers for decompression sickness.

The hospital has already treated three COVID-19 patients with hyperbaric oxygen therapy, with some promising results.

AI and the transformation of the medical world

Another great advantage is the ability to incorporate AI at early stages of image acquisition. Among other things, this enables us to reduce the amount of radiation needed to acquire a high-resolution CT or shorten the duration needed for an MRI scan. And this leads to patient welfare improvements as well as healthcare cost reductions.

AI applications

In recent years there has been tremendous work in this field mainly focusing on cardiovascular, ophthalmology, neurology, and cancer detection.

Sestrin makes fruit flies live longer

10% longer.

Reduced food intake, known as dietary restriction, leads to a longer lifespan in many animals and can improve health in humans. However, the molecular mechanisms underlying the positive effects of dietary restriction are still unclear. Researchers from the Max Planck Institute for Biology of Aging have now found one possible explanation in fruit flies: they identified a protein named Sestrin that mediates the beneficial effects of dietary restriction. By increasing the amount of Sestrin in flies, researchers were able to extend their lifespan and at the same time these flies were protected against the lifespan-shortening effects of a protein-rich diet. The researchers could further show that Sestrin plays a key role in stem cells in the fly gut thereby improving the health of the fly.

The health benefits of have long been known. Recently, it has become clear that restriction of certain food components, especially proteins and their individual building blocks, the , is more important for the organism’s response to dietary restriction than general calorie reduction. On the , one particular well-known signaling pathway, named TOR pathway, is important for longevity.

“We wanted to know which factor is responsible for measuring nutrients in the cell, especially amino acids, and how this factor affects the TOR pathway,” explains Jiongming Lu, researcher in the department of Linda Partridge at the Max Planck Institute for Biology of Aging. “We focused on a protein called Sestrin, which was suggested to sense amino acids. However, no one has ever demonstrated amino acid sensing function of Sestrin in a living being.” Therefore, Lu and his colleagues focused on the role of Sestrin in the model organism Drosophila melanogaster, commonly known as fruit fly.

A good COVID-19 vaccine is one that works for rich and poor alike

And, of course, there is patriarchy. In some parts of the world, women have no control over their health. It is the men – fathers, husbands and uncles – who decide what treatment “their” women receive. Humanitarians have seen men refuse emergency caesareans for their wives. They have also seen them refuse vaccinations for women whose bodies they effectively control.

The Oxford-AstraZeneca vaccine has launched the world on a pro-poor route to fair global vaccination against COVID-19. This is wonderful news. Now we need to address the challenges of a pro-poor roll-out. A major part of this must involve all States getting behind the COVAX effort to ensure fair global access to COVID-19 vaccination tools. It is good to see the UK co-leading on this with others.

Makers of grow-your-own human steaks say meal kit is not ‘technically’ cannibalism

The saying “You are what you eat” may soon become a lot more literal.

A “DIY meal kit” for growing steaks made from human cells was recently nominated for “design of the year” by the London-based Design Museum.

Named the Ouroboros Steak after the circular symbol of a snake eating itself tail-first, the hypothetical kit would come with everything one needs to use their own cells to grow miniature human meat steaks.