A simple ten-minute universal cancer test that can be detected by the human eye or an electronic device — published in Nature Communications (Dec 2018) by the Trau lab at the University of Queensland. Red indicates the presence of cancerous cells and blue doesn’t.
Sometimes the line between science and science fiction is blurry, and it can be interesting to look at sci-fi stories through the lens of real science. Previous blog posts have explored whether genome engineering could be used to create the X-Men and Hawkeye, and we now turn to investigate whether Ant-Man’s powers could be engineered using CRISPR.
The character Ant-Man is remarkable, but can a real-life Ant-Man be possible? Perhaps the most obvious roadblock is, well, the laws of physics. In the first movie, Ant-Man gets his ant-like powers thanks to fictitious “Pym particles,” which reduce the distance between atoms while increasing density and strength.
There is also the problem of scaling in biological systems. If kept in proportion, our bodily systems simply wouldn’t work well shrunken down. Read discussions about the physics and scaling of Ant-Man here and here.
Homicide kills far more people than armed conflict, says new UNODC study
VIENNA/NEW YORK, 8 July (UN Information Service) – Some 464,000 people across the world were killed in homicides in 2017, surpassing by far the 89,000 killed in armed conflicts in the same period, according to the Global Study on Homicide 2019 published today by the United Nations Office on Drugs and Crime (UNODC).
“The Global Study on Homicide seeks to shed light on gender-related killings, lethal gang violence and other challenges, to support prevention and interventions to bring down homicide rates,” said UNODC Executive Director Yury Fedotov. “Countries have committed to targets under the Sustainable Development Goals to reduce all forms of violence and related death rates by 2030. This report offers important examples of effective community-based interventions that have helped to bring about improvements in areas afflicted by violence, gangs and organized crime.”
Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of ageing and has been linked to ageing-related diseases like cancer. Senescent cells have been shown to accumulate in tissues of aged organisms which in turn can lead to chronic inflammation. Many genes have been associated with cell senescence, yet a comprehensive understanding of cell senescence pathways is still lacking. To this end, we created CellAge (http://genomics.senescence.info/cells), a manually curated database of 279 human genes associated with cellular senescence, and performed various integrative and functional analyses. We observed that genes promoting cell senescence tend to be overexpressed with age in human tissues and are also significantly overrepresented in anti-longevity and tumour-suppressor gene databases. By contrast, genes inhibiting cell senescence overlapped with pro-longevity genes and oncogenes. Furthermore, an evolutionary analysis revealed a strong conservation of senescence-associated genes in mammals, but not in invertebrates. Using the CellAge genes as seed nodes, we also built protein-protein interaction and co-expression networks. Clusters in the networks were enriched for cell cycle and immunological processes. Network topological parameters also revealed novel potential senescence-associated regulators. We then used siRNAs and observed that of 26 candidates tested, 19 induced markers of senescence. Overall, our work provides a new resource for researchers to study cell senescence and our systems biology analyses provide new insights and novel genes regarding cell senescence.
Not only has Su Metcalfe’s treatment succeeded in early trials, it involves zero drugs and no side effects—and it could begin human trials as soon as 2020.
Oklahoma Attorney General Mike Hunter had claimed that J&J and its pharmaceutical subsidiary Janssen aggressively marketed to doctors and downplayed the risks of opioids as early as the 1990s. The state said J&J’s sales practices created an oversupply of the addictive painkillers and “a public nuisance” that upended lives and would cost the state $12.7 billion to $17.5 billion. The state was seeking more than $17 billion from the company.
J&J, which marketed the opioid painkillers Duragesic and Nucynta, has denied any wrongdoing. Lawyers for the company disputed the legal basis Oklahoma used to sue J&J, relying on a “public nuisance” claim. They said the state has previously limited the act to disputes involving property or public spaces.
Investors were expecting J&J to be fined between $500 million and $5 billion, according to Evercore ISI analyst Elizabeth Anderson.
In one of the largest studies of its kind, researchers at Orlando Health are making new progress in finding ways to detect a traumatic yet sinister brain injury—and getting closer to preventing further damage.
Subconcussive injuries often show no symptoms or immediate effects, but can cause wear and tear on the brain over time with repeated injuries. The latest study, published in the journal BMJ Paediatrics Open, includes more than 700 emergency room patients—children and adults. The study gets us closer to developing a standard blood test to spot these injuries as early as possible.
“A unique feature of this study is that it includes patients who hit their heads but have no symptoms,” said Linda Papa, MD, lead author of the study and emergency medicine doctor at Orlando Health. “This group is rarely—if ever—included in biomarker studies.”
Mammals evolved in the face of fluctuating food availability. How the immune system adapts to…
ATLANTA—Targeting specific areas of the measles virus polymerase, a protein complex that copies the viral genome, can effectively fight the measles virus and be used as an approach to developing new antiviral drugs to treat the serious infectious disease, according to a study by the Institute for Biomedical Sciences at Georgia State University published in PLoS Pathogens.
Measles is a highly contagious virus that can lead to serious health complications and death. It begins with a fever, cough, runny nose and red eyes followed by a rash of tiny, red spots that starts at the head and spreads to the rest of the body. Although declared eliminated in the United States in 2000, the Centers for Disease Control and Prevention says the U.S. is experiencing the greatest number of measles cases reported since the early 1990s.
While an effective vaccine exists, there has been a steady decline in the number of people being vaccinated against the measles virus. Most new cases were among unvaccinated individuals, making the development of an effective treatment strategy complementing vaccination a public health priority. There are no antivirals licensed to treat measles. The new study identified a novel protein interface in the polymerase complex that is pivotal for the regulation of polymerase activity, providing a new objective for target-based antiviral drug discovery.
Scientists have identified a class of drugs that may have potential to treat a rare and deadly form of brain cancer that affects young children.
The research team, led by Ranjit Bindra, MD, PhD, and colleagues at the Yale Cancer Center, also included co-senior authors Charles Brenner, PhD, professor and DEO of biochemistry at the University of Iowa Carver College of Medicine, and Michael E. Berens, PhD, from the Translational Genomics Research Institute in Phoenix.
The findings, published Aug. 22 in Nature Communications, focus on Diffuse Intrinsic Pontine Glioma (DIPG), a rare, incurable cancer that affects the brainstem in children under age 10. Previous work had identified mutations in a gene called PPM1D as a cause of this cancer.
