Lifeboat Foundation

The ability to edit genes in living organisms offers the opportunity to treat a plethora of inherited diseases. However, many types of gene-editing tools are unable to target critical areas of DNA, and creating such a technology has been difficult as living tissue contains diverse types of cells.

Now, Salk Institute researchers have developed a new tool—dubbed SATI—to edit the mouse genome, enabling the team to target a broad range of mutations and cell types. The new genome-editing technology, described in Cell Research on August 23, 2019, could be expanded for use in a broad range of gene mutation conditions such as Huntington’s disease and the rare premature aging syndrome, progeria.

“This study has shown that SATI is a powerful tool for genome editing,” says Juan Carlos Izpisua Belmonte, a professor in Salk’s Gene Expression Laboratory and senior author of the paper. “It could prove instrumental in developing effective strategies for target-gene replacement of many different types of mutations, and opens the door for using genome-editing tools to possibly cure a broad range of genetic diseases.”

In new research published in Psychoneuroendocrinology, scientists have shown that loving-kindness meditation has a positive impact at the cellular level. The study examined how different types of meditation influenced telomere length, an indicator of physiological aging.

Telomeres are the end caps of DNA on our chromosomes, which help in DNA replication and get shorter over time.

“Chronological age and biological age are not identical. The former is measured in years, whereas the latter is often indexed by telomere length,” the authors of the new study explained. “Telomeres progressively shorten with cell division (i.e., aging) in general, but may also be replenished, or lengthened, by the enzyme telomerase.”

A South African professor, Mashudu Tshifularo, and his team at the University of Pretoria pioneered the world’s first middle ear transplant using 3D-printed bones. Here is how he carried out the successful surgery.

What should you chose to get the best pain relief? StemCures in Cincinnati.

Science has officially broadened the blood supply:

Access to efficient enzymes that can convert A and B type red blood cells to ‘universal’ donor O would greatly increase the supply of blood for transfusions. Here we report the functional metagenomic screening of the human gut microbiome for enzymes that can remove the cognate A and B type sugar antigens. Among the genes encoded in our library of 19,500 expressed fosmids bearing gut bacterial DNA, we identify an enzyme pair from the obligate anaerobe Flavonifractor plautii that work in concert to efficiently convert the A antigen to the H antigen of O type blood, via a galactosamine intermediate. The X-ray structure of the N-acetylgalactosamine deacetylase reveals the active site and mechanism of the founding member of an esterase family. The galactosaminidase expands activities within the CAZy family GH36. Their ability to completely convert A to O of the same rhesus type at very low enzyme concentrations in whole blood will simplify their incorporation into blood transfusion practice, broadening blood supply.

Melanoma is a deadly form of skin cancer that has been increasing in the U.S. for the past 30 years. Nearly 100,000 new cases of melanoma are diagnosed every year, and 20 Americans die every day from it, according to the American Academy of Dermatology. Now, researchers have developed a fast-acting skin patch that efficiently delivers medication to attack melanoma cells. The device, tested in mice and human skin samples, is an advance toward developing a vaccine to treat melanoma and has widespread applications for other vaccines.

The researchers will present their findings today at the American Chemical Society (ACS) Fall 2019 National Meeting and Exposition.

“Our patch has a unique chemical coating and mode of action that allows it to be applied and removed from the skin in just a minute while still delivering a therapeutic dose of drugs,” says Yanpu He, a graduate student who helped develop the device. “Our patches elicit a robust antibody response in living mice and show promise in eliciting a strong immune response in human skin.”

Stem cell biologist Hiromitsu Nakauchi has been waiting for this moment for more than a decade.

After years of planning, the persistent researcher has at last received approval from a government willing to pursue one of the most controversial scientific studies there is: human-animal embryo experiments.

While many countries around the world have restricted, defunded or outright banned these ethically-fraught practices, Japan has now officially lifted the lid on this proverbial Pandora’s box. Earlier this year, the country made it legal to not only transplant hybrid embryos into surrogate animals, but also to bring them to term.

At Ending Age-Related Diseases, Michael Greve discussed the Forever Healthy Foundation and its Rejuvenation Now initiative along with the current state of rejuvenation biotechnology, including companies and therapies, and a direction for the future of this emerging industry.

See Forever Healthy’s Rejuvenation Now initiative at https://forever-healthy.org/en/initiatives/rejuvenation-now/

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Senescent cells are key drivers of the ageing process — and a new generation of drugs is seeking to banish them from our body.