Lifeboat Foundation

The disability burden for people with multiple sclerosis (MS) can vary significantly depending on whether they have a relapsing/remitting form of the disease, where they experience periods of clinical remission, or a progressive form, where they have continued neurological deterioration without clinical remission. Effective therapies exist for managing relapsing/remitting MS, but treatment for progressive MS has proved more challenging. Now, a new paper published in the journal Brain from researchers at the Advanced Science Research Center (ASRC) at The Graduate Center, CUNY and Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai has identified potential mechanisms that may inform the development of therapies that effectively manage progressive MS.

Previous research had suggested that dysfunction of neuronal mitochondria—the energy-producing subcellular organelles—occurs in the brains of MS patients with progressive clinical disability. However, the molecular mechanisms underlying this process remained elusive.

“Because the brain is bathed by the cerebrospinal fluid (CSF), we asked whether treating cultured neurons with the CSF from MS patients with a relapsing/remitting or a progressive disease course would possibly elicit different effects on neuronal mitochondrial function,” said the study’s primary investigator Patrizia Casaccia, Einstein Professor of Biology at The Graduate Center and founding director of the Neuroscience Initiative at the ASRC. “We detected dramatic differences in the shape of the neuronal mitochondria and their ability to produce energy. Only exposure to the CSF from progressive MS patients caused neuronal mitochondria to fuse and elongate while rendering them unable to produce energy. We therefore searched for potential mechanisms of CSF-induced neurodegeneration with the intent to define therapeutic strategies.”

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This atlas of human CoRSIVs,” they write, “provides a resource for future population-based investigations into how interindividual epigenetic variation modulates risk of disease,” and may well transform understanding of the causes of illness in the human body.

A project 370 times larger than the Human Genome Project bears first fruit. Stephen Fleischfresser reports.

Any major breakthrough in extending human life would drastically alter population projections. The social effects, while obviously huge, would depend on whether the years of senility were prolonged, too; whether women’s age at menopause would increase; and how families would be structured if many generations were alive at the same time. Expensive treatments to extend human lives could also have implications for inequality; as in many other areas of technology, the wealthy would be most able to afford such services.

Almost everyone would welcome an extension of their healthy lifespan, and some scientists are looking at increasingly extreme ways to achieve that. But any major breakthrough in this area could have unwanted and far-reaching demographic, social, and economic implications.

CAMBRIDGE – Humans have long sought the elixir of youth, so it is not surprising that even non-scientists closely follow the latest research into aging. But is what most people consider simply a fact of life actually a “disease” that can be cured? Or is there some insurmountable limit to the lifespan of human bodies?

Continue reading “Is Immortality Worth It?” »

https://www.youtube.com/watch?v=qQKaCTdrmJc&feature=youtu.be

The modern biographical story of Stanislaw Burzynski, MD, PhD who discovered an innovative patent-protected cancer therapy currently enrolled in FDA clinical trials. This story sheds light on the current regulatory and industry roadblocks preventing these life-saving medications from reaching the market as of 2016.

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Continue reading “The Cancer Cure Cover-Up (Conspiracy Documentary) — Real Stories” »

An excellent interview. Fossel and Aubrey de Grey of the SENS Foundation are in disagreement about telomerase.

https://www.singularityweblog.com/michael-fossel/ ‎

Continue reading “Dr. Michael Fossel: Compassion is the reason to reverse aging!” »

Should doctors allow their expertise to trump a patient’s personal goals — or should they yield to it? In this video, physician and author Matt McCarthy describes how doctors make difficult decisions in fast-paced environments.

This can also be done with a brain in a jar hooked-up to A.I…

*** As featured on the Colbert Report — June 4, 2009 ***

Continue reading “EX VIVO LUNG: Transplant surgeons at Toronto General Hospital make medical history” »