Lifeboat Foundation

The evolution of human diets led to preferences toward polyunsaturated fatty acid (PUFA) content with ‘Western’ diets enriched in ω-6 PUFAs. Mounting evidence points to ω-6 PUFA excess limiting metabolic and cognitive processes that define longevity in humans. When chosen during pregnancy, ω-6 PUFA-enriched ‘Western’ diets can reprogram maternal bodily metabolism with maternal nutrient supply precipitating the body-wide imprinting of molecular and cellular adaptations at the level of long-range intercellular signaling networks in the unborn fetus. Even though unfavorable neurological outcomes are amongst the most common complications of intrauterine ω-6 PUFA excess, cellular underpinnings of life-long modifications to brain architecture remain unknown. Here, we show that nutritional ω-6 PUFA-derived endocannabinoids desensitize CB1 cannabinoid receptors, thus inducing epigenetic repression of transcriptional regulatory networks controlling neuronal differentiation. We found that cortical neurons lose their positional identity and axonal selectivity when mouse fetuses are exposed to excess ω-6 PUFAs in utero. Conversion of ω-6 PUFAs into endocannabinoids disrupted the temporal precision of signaling at neuronal CB1 cannabinoid receptors, chiefly deregulating Stat3-dependent transcriptional cascades otherwise required to execute neuronal differentiation programs. Global proteomics identified the immunoglobulin family of cell adhesion molecules (IgCAMs) as direct substrates, with DNA methylation and chromatin accessibility profiling uncovering epigenetic reprogramming at 1400 sites in neurons after prolonged cannabinoid exposure. We found anxiety and depression-like behavioral traits to manifest in adult offspring, which is consistent with genetic models of reduced IgCAM expression, to suggest causality for cortical wiring defects. Overall, our data uncover a regulatory mechanism whose disruption by maternal food choices could limit an offspring’s brain function for life.

• Immediate Communication
• Published: 18 November 2019

• Valentina Cinquina ¹,
• Daniela Calvigioni ¹,
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PHILADELPHIA—Stents and coronary artery bypass surgery are no more effective than intensive drug treatment and better health habits in preventing millions of Americans from heart attacks and death, a large study found, shedding new light on a major controversy in cardiology.

Researchers and doctors have fiercely debated for years how best to treat people who have narrowed coronary arteries but aren’t suffering acute symptoms.

The Times

Scientists used a computer program to uncover more than 1 million molecules that could potentially store genetic information, just like DNA.

It seems incredible that scientists have discovered a new human organ. I mean, they cut people open right and left (living and dead). How could they miss anything?

Well, they did. A new organ has been identified. Actually, two. Plus a new “structure” that is not quite an organ.

First, the “structure”: In 2017, an elaborate system of drainage vessels was seen in the brain for the first time. Until then their existence was suspected, but not certain.

Drug therapy alone may save lives as effectively as bypass or stenting procedures, a large federal study showed.

Ira Pastor ideaXme exponential health ambassador interviews Mr. Dennis Kowalski, Cryonics Institute President, EMT-paramedic, certified in advanced cardiac life support (ACLS), advanced pediatric life support (PALS), a CPR Instructor for the American Heart Association, and a fire fighter!

Ira Pastor comments: Cryonics is defined as the extremely low-temperature freezing (or vitrification — converting into glass or a glass-like substance) usually at −196 °C or −320.8 °F or 77.1 K, and storage of a human body or part of a human body, with the hope that resurrection may be possible in the future.

Continue reading “Cryonics: Ambulance To The Future?” »

Merging of human biological arrangements with nonbiological machine hardware is perhaps not fairy at all. Futurist Ray Kurzweil mentioned his fairy dream over again that the historic Homo sapiens are not so far remote to the fifth epoch revolution. They human species is cramped to leave their biological genes and sluggish brain circuitry to merging them with the electrified hardware and fastest machine intelligence. Merging with electrified intelligence is unavoidable because of the slow computation power of human brain circuitry. Information processing and its exchanging ratio of a biological brain are extremely sluggish compared to the nonbiological brain. Despite its amazing innovative capacity of thinking, envision or consciousness, the human brain looks crawler if a goosey person even observes the current computation pace of nonbiological machine-brain for instance.

… Daniel Kahneman’s evidential works help readers summate the conclusion that the battle amid desire and choice is not an episodic whiff of latter, nor anybody can consider it a consequent tethering of modernity, rather the prehistoric beginning was also alluring by this in a bit different context. Memory-preserver neuron cells how to make a deep impact on human happiness levels have appeared crucial in Kahneman’s investigation. … …

Harari’s conversation with Kahneman echoed his historical findings that how human species manipulate Nature in an excuse to achieve individuality and happiness. He put forward statistical references to establish his findings of the behavioral shifting of human civilization; that is,— the personification of Naturebond life then diverts human species to a different track. They missed the integrity of taking Holistic View that a ‘piece or segment’ is ultimately the part of a ‘whole’ and any partial piece or segment never sustains long if it failed attached itself to the whole. Lil bit reminder of Chief Seattle’s Letter may relevant here. It is said that the native leader once wrote a letter to the President of the United States addressing the burning land settlement issues against his tribe:

Continue reading “Is death optional? ⇒ Kirno Sohochari” »