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Category: biotech/medical – Page 1,719

Cancer Mortality Among People Living in Areas With Various Levels of Natural Background Radiation

There are many places on the earth, where natural background radiation exposures are elevated significantly above about 2.5 mSv/year. The studies of health effects on populations living in such places are crucially important for understanding the impact of low doses of ionizing radiation. This article critically reviews some recent representative literature that addresses the likelihood of radiation-induced cancer and early childhood death in regions with high natural background radiation. The comparative and Bayesian analysis of the published data shows that the linear no-threshold hypothesis does not likely explain the results of these recent studies, whereas they favor the model of threshold or hormesis. Neither cancers nor early childhood deaths positively correlate with dose rates in regions with elevated natural background radiation.

Keywords: natural radiation, background radiation, HBRA, HNBR, low radiation, cancer, hormesis.

Scientists connect human brain to computer wirelessly for first time ever

The first wireless commands to a computer have been demonstrated in a breakthrough for people with paralysis.

The system is able to transmit brain signals at “single-neuron resolution and in full broadband fidelity”, say researchers at Brown University in the US.

A clinical trial of the BrainGate technology involved a small transmitter that connects to a person’s brain motor cortex.

Antiaging Has to Cure Frailty or It Does Not Work

If we look at the mortality tables, it can explain why reversing aging damage reversal has to work very well for people to live very long lives.

Let us imagine that we are able to reverse aging damage so that someone is 65 or older has the same amount of aging as someone who is 65. This means for an average American man, then half of those people will still be dead by the time they have reached 95 years of age. This is because 1.6% of them are dying every year in the 65-year-old condition. Also, only 80% of them have survived from birth to the age of 65.

Asian American women in New Jersey live to a life expectancy of 93. Half of them reach the age of 93. Antiaging that reverses the aging damage every year for men so that they never get worse physically than when they are 65, get them to a life expectancy that is just beyond what Asian American women in New Jersey already achieve.

Gene Changes Linked to Severe Repetitive Behaviors Seen in Autism, Schizophrenia, and Drug Addiction

“Our new data suggest that the upregulation of Neuregulin-responsive genes in animals with severely repetitive behaviors reflects gene changes in the striosomal neurons that control the release of dopamine,” Crittenden explains. “Dopamine can directly impact whether an animal repeats an action or explores new actions, so our study highlights a potential role for a striosomal circuit in controlling action-selection in health and in neuropsychiatric disease.”

Graybiel lab identifies genes linked to abnormal repetitive behaviors often seen in models of addiction and schizophrenia.

Extreme repetitive behaviors such as hand-flapping, body-rocking, skin-picking, and sniffing are common to a number of brain disorders including autism, schizophrenia, Huntington’s disease, and drug addiction. These behaviors, termed stereotypies, are also apparent in animal models of drug addiction and autism.

In a new study published in the European Journal of Neuroscience, researchers at the McGovern Institute for Brain Research have identified genes that are activated in the brain prior to the initiation of these severe repetitive behaviors.

Revolutionary Research: Scientists Create First Model of an Early Human Embryo From Skin Cells

For first time, fibroblast-derived model of early embryo will allow extensive study into causes of very early miscarriage and effects of toxins and drugs on early development.

In a discovery that will revolutionize research into the causes of early miscarriage, infertility and the study of early human development — an international team of scientists led by Monash University in Melbourne, Australia has generated a model of a human embryo from skin cells.

The team, led by Professor Jose Polo, has successfully reprogrammed these fibroblasts or skin cells into a 3-dimensional cellular structure that is morphologically and molecularly similar to human blastocysts. Called iBlastoids, these can be used to model the biology of early human embryos in the laboratory.

A Single Injection Reverses Blindness in Patient with Rare Genetic Disorder – Another RNA Success

A patient with a genetic form of childhood blindness gained vision, which lasted more than a year, after receiving a single injection of an experimental RNA therapy into the eye.

The gene editing research was conducted at the Perelman School of Medicine in the University of Pennsylvania. Results of the case, detailed in a paper published April 1 in Nature Medicine, show that the treatment led to marked changes at the fovea, the most important point of human central vision.

In the international clinical trial, participants received an intraocular injection of an antisense oligonucleotide called sepofarsen. This short RNA molecule works by increasing normal CEP290 protein levels in the eye’s photoreceptors and improving retinal function under day vision conditions.

Gut Bacteria Boost Host NAD Metabolism

Here’s my latest video (audio issues fixed!):

Papers referenced in the video:

Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway:
https://pubmed.ncbi.nlm.nih.gov/32130883/

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism:
https://pubmed.ncbi.nlm.nih.gov/27304511/

Aerobic and resistance exercise training reverses age-dependent decline in NAD + salvage capacity in human skeletal muscle:

Continue reading “Gut Bacteria Boost Host NAD Metabolism” | >

Dr. María Blasco refers to Telomerase and Life Extension (in English with S/T en Español)

Extract from a conversation that María Blasco, Director of the Spanish National Cancer Research Center (CNIO for its acronym in Spanish) had with Mario Alonso Puig during the celebration of the South Summit 2020.

In this segment María Blasco refers to aging, cancer, telomerase, and life extension. The conversation is in English and I added subtitles in Spanish.

I find the message particularly important because Dr. María Blasco refers again (she already did it in a scientific paper) to the fact that, contrary to what she herself would have expected and was a concern within the scientific community, inducing the production of Telomerase in mice, besides from lengthening significantly their healthspan and lifespan, not only it did not cause Cancer but quite the opposite, reduced or even eliminated the occurrence of it.