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Category: biotech/medical – Page 168

Study Reveals a Turning Point When Men’s Heart Attack Risk Accelerates

Screening at an earlier age can help identify risk factors sooner, enabling preventive strategies that reduce long-term risk.

Screening for heart attack risk should be happening earlier for men, according to a new study that found the risk of cardiovascular disease starts climbing when men are in their mid-30s – significantly earlier than a similar trend is seen in women.

The US-based researchers behind the study followed the health of 5,112 people for an average of around 34 years. As the participants were healthy and aged 18–30 when the study started in the mid-1980s, the researchers could chart cases of cardiovascular disease (including strokes and heart failure) over time.

According to the data, 35 is the critical age when disparities between male and female cardiovascular disease risk start to appear. Most of the difference is driven by coronary heart disease (CHD), the most common cause of heart attacks, where fatty deposits clog up arteries, blocking blood flow.

Newly identified RNA molecule may drive cancer patient survival

In a recent study, researchers at the Texas A&M University Health Science Center (Texas A&M Health) identify a novel RNA molecule that plays a crucial role in preserving the integrity of a key cellular structure, the nucleolus. Their findings also suggest this molecule may influence patient survival in certain blood cancers. The work is published in the Proceedings of the National Academy of Sciences.

Two-step approach creates more sustainable protein nanostructures for advanced sensing and therapeutics

Gas vesicles are among the largest known protein nanostructures produced and assembled inside microbial cells. These hollow, air-filled cylindrical nanostructures found in certain aquatic microbes have drawn increasing interest from scientists due to their potential for practical applications, including as part of novel diagnostic and therapeutic tools. However, producing gas vesicles is a difficult task for cells in the lab, hindering the development of applications.

In a study recently published in Nature Communications, a team of researchers led by Rice University bioengineer George Lu reports the development of a new genetic regulatory system to improve cell viability during the production of gas vesicles.

“In the past few years, studies have shown that gas vesicles’ ability to reflect sound makes them useful as unique and versatile acoustic reporter systems for biomedical research and clinical applications,” said Lu, an assistant professor in the Department of Bioengineering at Rice’s George R. Brown School of Engineering and Computing.

Brain microenvironment redefines metastatic tumor subtypes, facilitating precision oncology treatment

An interdisciplinary multi-center research team led by the LKS Faculty of Medicine (HKUMed) and Faculty of Dentistry at the University of Hong Kong has constructed the world’s largest multi-omics atlas of brain metastases. This comprehensive analysis included 1,032 brain metastasis samples from diverse primary tumors, together with 82 matched primary tumors and 20 glioblastomas (a highly malignant type of brain tumor) as controls.

The findings provide a novel framework for classifying brain metastases and establish a foundation for the development of personalized treatment strategies, advancing the field of precision oncology. This research was published in the journal Nature Communications.

A clearer look at critical materials, thanks to refrigerator magnets

With an advanced technology known as angle-resolved photoemission spectroscopy (ARPES), scientists are able to map out a material’s electron energy-momentum relationship, which encodes the material’s electrical, optical, magnetic and thermal properties like an electronic DNA. But the technology has its limitations; it doesn’t work well under a magnetic field. This is a major drawback for scientists who want to study materials that are deployed under or even actuated by magnetic fields.

Inspired by refrigerator magnets, a team of Yale researchers may have found a solution. Their study was featured recently on the cover of The Journal of Physical Chemistry Letters.

Quantum materials —such as unconventional superconductors or topological materials—are considered critical to advancing quantum computing, high-efficiency electronics, nuclear fusion, and other fields. But many of them need to be used in the presence of a magnetic field, or even only become activated by magnetic fields. Being able to directly study the electronic structure of these materials in magnetic fields would be a huge help in better understanding how they work.

Cancer-associated fibroblast-derived extracellular vesicles deliver ATP6V1C1 to promote lung adenocarcinoma metastasis via the ID1-IGFBP3 axis

Chen et al. reveal the V-ATPase subunit ATP6V1C1 as a non-canonical transcriptional repressor delivered by CAF-derived EVs to drive LUAD metastasis. By suppressing IGFBP3, ATP6V1C1 simultaneously triggers EMT and amplifies stromal IGF1 signaling, creating a potent pro-metastatic feedforward loop.

A Parasite Carried by Billions Has a Secret Life Inside the Brain

A common parasite hiding in the brain turns out to be far more active and organized than anyone realized.

A team of scientists at the University of California, Riverside, has discovered that Toxoplasma gondii, a parasite estimated to infect up to one-third of the world’s population, is far more biologically complex than previously understood. Their findings, published in Nature Communications, provide new insight into how the parasite causes disease and why it has proven so difficult to eliminate with current treatments.

How Toxoplasmosis Spreads in Humans.

Scientists Identified a New Blood Group After a 50-Year Mystery

It represents a huge achievement, and the culmination of a long team effort.

A pregnant woman’s blood sample taken in 1972 was mysteriously missing a surface molecule found on all other known red blood cells at the time.

More than 50 years later, that strange absence finally led researchers from the UK and Israel to describe a new blood group system in humans. The team published a paper on the discovery in 2024.

“It represents a huge achievement, and the culmination of a long team effort, to finally establish this new blood group system and be able to offer the best care to rare, but important, patients,” hematologist Louise Tilley from the UK National Health Service said in September 2024, after nearly 2 decades of personally researching this bloody quirk.

Cells adapt to aging by actively remodeling endoplasmic reticulum, study reveals

Improvements in public health have allowed humankind to survive to older ages than ever before, but, for many people, these added golden years are not spent in good health. Aging is a natural part of life, but it is associated with a greatly increased incidence of most chronic diseases, including various cancers, diabetes, and Alzheimer’s disease.

The laboratory of Kris Burkewitz, assistant professor of cell and developmental biology, wants to figure out if there is a way to break the links between the aging process and disease so that we can stay healthy longer, allowing us to better enjoy our later years. To accomplish this goal, the Burkewitz lab focuses on how cells organize their internal compartments, or organelles, and how organelle structures can influence cellular function, metabolism, and disease risk.

In his most recent paper, published in Nature Cell Biology, Burkewitz describes a new way by which cells adapt to the aging process: by actively remodeling the endoplasmic reticulum, one of the cell’s largest and most complex organelles. His team found that aging cells remodel their ER through a process called ER-phagy, which selectively targets specific ER subdomains for breakdown. The discovery that ER-phagy is involved in aging highlights this process as a possible drug target for age-related chronic conditions such as neurodegenerative diseases and various metabolic disease contexts.

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