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In Its Greatest Biology Feat Yet, AI Unlocks the Complex Proteins Guarding Our DNA

Yet when faced with enormous protein complexes, AI faltered. Until now. In a mind-bending feat, a new algorithm deciphered the structure at the heart of inheritance—a massive complex of roughly 1,000 proteins that helps channel DNA instructions to the rest of the cell. The AI model is built on AlphaFold by DeepMind and RoseTTAfold from Dr. David Baker’s lab at the University of Washington, which were both released to the public to further experiment on.

Our genes are housed in a planet-like structure, dubbed the nucleus, for protection. The nucleus is a high-security castle: only specific molecules are allowed in and out to deliver DNA instructions to the outside world—for example, to protein-making factories in the cell that translate genetic instructions into proteins.

At the heart of regulating this traffic are nuclear pore complexes, or NPCs (wink to gamers). They’re like extremely intricate drawbridges that strictly monitor the ins and outs of molecular messengers. In biology textbooks, NPCs often look like thousands of cartoonish potholes dotted on a globe. In reality, each NPC is a massively complex, donut-shaped architectural wonder, and one of the largest protein complexes in our bodies.

Incredible Virus Discovery Offers Clues About the Origins of Complex Life

Omuterema AkhahendaAdmin.

I remember when my friends worked at a Motorola Chip fabrication plant in San Antonio. They had the facilities, as well as skilled labor. However, cheaper labor led many to invest abroad. I even changed my major from computer science, as I heard of thi… See more.

Anne KristoffersenWell — Orbital semiconductor fabrication should be pursued, there are so many benefits to making chips in a naturally micro-gravity, hard-vacuum environment.

Notably, you aren’t using any water, and your silicon wafers can be arbitrarily large.… See more.

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Nanotechnology spans many disciplines

Nanotechnologist and co-founder of the Black in Nanotech initiative, Olivia Geneus. (Courtesy: Alexander Harold) Welcome to this Physics World Nanotechnology Briefing, which showcases the breadth of applications of modern nanotechnology.

Olivia Geneus is one of the growing number of scientists who are developing nanotechnologies for medicine. In an interview, the PhD student at the State University of New York at Buffalo explains how she is developing nanoparticles designed to cross the blood–brain barrier in order to image and destroy brain cancer cells. Geneus also talks about Black in Nanotech Week, which she co-founded, and the need to encourage Black children to consider careers in science.

Ed Lester of the UK’s University of Nottingham knows that there are myriad uses for nanoparticles. In 2007 he founded the company Promethean Particles when he realized industrial users were not able to source nanoparticles in the quantities and quality that they required. In an interview, Lester talks about some of the company’s development projects including nanoparticles for aviation, healthcare and energy.

Nanomesh pressure sensor preserves skin’s sense of touch

Takao Someya and colleagues at the University of Tokyo have developed the first artificial-skin patch that does not affect the touch sensitivity of the real skin beneath it. The new ultrathin sensor could be used in applications as diverse as prosthetics and human-machine interfaces.

“A wearable sensor for your fingers has to be extremely thin,” explains Tokyo’s Sunghoon Lee. “But this obviously makes it very fragile and susceptible to damage from rubbing or repeated physical actions.” For this reason most e-skins developed to date been relatively thick and bulky.

In contrast, the sensor developed by the Tokyo team is thin and porous and consists of two layers (Science 370 966). The first layer is an insulating mesh-like network comprising polyurethane fibres around 200–400 nm thick. The second layer is a network of lines that makes up the functional electronic part of the device – a parallel-plate capacitor. This is made of gold on a supporting scaffold of polyvinyl alcohol (PVA), a water-soluble polymer often found in contact lenses. Once this layer has been fabricated, the PVA is washed away to leave only the gold support. The finished pressure sensor is around 13 μ m thick.

Nanotube artificial muscles pick up the pace

An electrochemically powered artificial muscle made from twisted carbon nanotubes contracts more when driven faster thanks to a novel conductive polymer coating. Developed by Ray Baughman of the University of Texas at Dallas in the US and an international team, the device overcomes some of the limitations of previous artificial muscles, and could have applications in robotics, smart textiles and heart pumps.

Carbon nanotubes (CNTs) are rolled-up sheets of carbon with walls as thin as a single atom. When twisted together to form a yarn and placed in an electrolyte bath, CNTs expand and contract in response to electrochemical inputs, much like a natural muscle. In a typical set-up, a potential difference between the yarn and an electrode drives ions from the electrolyte into the yarn, causing the muscle to actuate.

While such CNT muscles are highly energy efficient and extremely strong – they can lift loads up to 100,000 times their own weight – they do have limitations. The main one is that they are bipolar, meaning that the direction of their movement switches whenever the potential drops to zero. This reduces the overall stroke of the actuator. Another drawback is that the muscle’s capacitance decreases when the potential is changed quickly, which also causes the stroke to decrease.

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