Welcome to the Siim Land Podcast I’m your host Siim Land and our guest today is Liz Parish. Liz is the founder and CEO of BioViva. Which is a company committed to extending human lifespan using techniques such as gene and cell technologies. Liz Parrish became the first person worldwide to take dual gene therapies for treating aging.
The creatures made famous by Game of Thrones went extinct some 13000 years ago. Now geneticists know a little more about where they come from.
Stuck at home with time on their hands, millions of amateurs around the world are gathering information on everything from birds to plants to Covid-19 at the request of institutional researchers. And while quarantine is mostly a nightmare for us, it’s been a great accelerant for science.
From backyard astronomy to birding, amateurs have been busy collecting data — and making real discoveries.
The process of systems integration (SI) functionally links together infrastructure, computing systems, and applications. SI can allow for economies of scale, streamlined manufacturing, and better efficiency and innovation through combined research and development.
New to the systems integration toolbox are the emergence of transformative technologies and, especially, the growing capability to integrate functions due to exponential advances in computing, data analytics, and material science. These new capabilities are already having a significant impact on creating our future destinies.
The systems integration process has served us well and will continue to do so. But it needs augmenting. We are on the cusp of scientific discovery that often combines the physical with the digital—the Techno-Fusion or merging of technologies. Like Techno-Fusion in music, Techno-Fusion in technologies is really a trend that experiments and transcends traditional ways of integration. Among many, there are five grouping areas that I consider good examples to highlight the changing paradigm. They are: Smart Cities and the Internet of Things (IoT); Artificial Intelligence (AI), Machine Learning (ML), Quantum and Super Computing, and Robotics; Augmented Reality (AR) and Virtual Reality Technologies (VR); Health, Medicine, and Life Sciences Technologies; and Advanced Imaging Science.
The new clinical trial data shows a single shot of the vaccine “gives sustainable antibodies,” Dr. Paul Stoffels, J&J chief scientific officer, told CNBC.
A team of researchers at Columbia University has developed a way to allow DNA strands to store more data. In their study, published in the journal Science, the group applied a small amount of electricity to DNA strands to allow for encoding more information than was possible with other methods.
For several years, researchers have been looking for ways to increase data storage capacity—storage requirements are expected to exceed capacity in the near future as demand skyrockets. One such approach has involved encoding data into strands of DNA—prior research has shown that it is possible. In the early stages of such research, scientists manually edited strands to add characteristics to represent zeroes or ones. More recently, researchers have used the CRISPR gene editing tool. Most such studies used DNA extracted from the tissue of deceased animals. More recently, researchers have begun efforts to move the research to living animals because it will last longer. And not just in the edited strands—the information they contain could conceivably be passed on to offspring, allowing data to be stored for very long periods of time.
Back in 2017, another team at Columbia University used CRISPR to detect a certain signal—in their case, it was the presence of sugar molecules. Adding such molecules resulted in gene expressions of plasmid DNA. Over time, the editing process was improved as genetic bits were added to represent ones and zeroes. Unfortunately, the system only allowed for storing a few bits of data.
Researchers at Columbia Engineering report today that they have developed the first nanomaterial that demonstrates “photon avalanching,” a process that is unrivaled in its combination of extreme nonlinear optical behavior and efficiency. The realization of photon avalanching in nanoparticle form opens up a host of sought-after applications, from real-time super-resolution optical microscopy, precise temperature and environmental sensing, and infrared light detection, to optical analog-to-digital conversion and quantum sensing.
“Nobody has seen avalanching behavior like this in nanomaterials before,” said James Schuck, associate professor of mechanical engineering, who led the study published today by Nature. “We studied these new nanoparticles at the single-nanoparticle level, allowing us to prove that avalanching behavior can occur in nanomaterials. This exquisite sensitivity could be incredibly transformative. For instance, imagine if we could sense changes in our chemical surroundings, like variations in or the actual presence of molecular species. We might even be able to detect coronavirus and other diseases.”
Avalanching processes—where a cascade of events is triggered by series of small perturbations—are found in a wide range of phenomena beyond snow slides, including the popping of champagne bubbles, nuclear explosions, lasing, neuronal networking, and even financial crises. Avalanching is an extreme example of a nonlinear process, in which a change in input or excitation leads to a disproportionate—often disproportionately large—change in output signal. Large volumes of material are usually required for the efficient generation of nonlinear optical signals, and this had also been the case for photon avalanching, until now.
“This is perhaps the hardest part of all DNA storage approaches. If you can get the cells to directly talk to a computer, and interface its DNA-based memory system with a silicon-based memory system, then there are lots of possibilities in the future.”
The work builds on a CRISPR-based cellular recorder Wang had previously designed for E. coli bacteria, which detects the presence of certain DNA sequences inside the cell and records this signal into the organism’s genome.
The system includes a DNA-based “sensing module” that produces elevated levels of a “trigger sequence” in response to specific biological signals. These sequences are incorporated into the recorder’s “DNA ticker tape” to document the signal.
A keen sense of smell is a powerful ability shared by many organisms. However, it has proven difficult to replicate by artificial means. Researchers combined biological and engineered elements to create what is known as a biohybrid component. Their volatile organic compound sensor can effectively detect odors in gaseous form. They hope to refine the concept for use in medical diagnosis and the detection of hazardous materials.
Electronic devices such as cameras, microphones and pressure sensors enable machines to sense and quantify their environments optically, acoustically and physically. Our sense of smell however, despite being one of nature’s most primal senses, has proven very difficult to replicate artificially. Evolution has refined this sense over millions of years and researchers are working hard to catch up.
“Odors, airborne chemical signatures, can carry useful information about environments or samples under investigation. However, this information is not harnessed well due to a lack of sensors with sufficient sensitivity and selectivity,” said Professor Shoji Takeuchi from the Biohybrid Systems Laboratory at the University of Tokyo. “On the other hand, biological organisms use odor information extremely efficiently. So we decided to combine existing biological sensors directly with artificial systems to create highly sensitive volatile organic compound (VOC) sensors. We call these biohybrid sensors.”
Summary: Scientists have long marveled at the rejuvenating effects of heterochronic parabiosis. When you mix the blood of a young mouse and an old mouse by joining their circulatory systems, the older animal recovers some features of youth, while the young animal becomes functionally older. While many have assumed that these effects were driven by the infusion of pro-youth factors from the young parabiont into the older one, an alternative “Dilution Solution” hypothesis is possible: that the young blood is instead diluting pro-aging factors from the old animal’s blood, as well as allowing the young animal’s livers and kidneys to filter out metabolic toxins through the young animals’ livers and kidneys.
In heterochronic parabiosis, joining the circulatory systems of young and old mice causes the older animal to recover some features of youth. The effect has been widely assumed to be driven by pro-youth factors in younger blood, but an alternative hypothesis is possible: that the procedure is instead diluting pro-aging factors in the older partner.
