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Researchers develop methodology for streamlined control of material deformation

Can you crumple up two sheets of paper the exact same way? Probably not—the very flexibility that lets flexible structures from paper to biopolymers and membranes undergo many types of large deformations makes them notoriously difficult to control. Researchers from the Georgia Institute of Technology, Universiteit van Amsterdam, and Universiteit Leiden have shed new light on this fundamental challenge, demonstrating that new physical theories provide precise predictions of the deformations of certain structures, as recently published in Nature Communications.

In the paper, Michael Czajkowski and D. Zeb Rocklin from Georgia Tech, Corentin Coulais from Universiteit van Amsterdam, and Martin van Hecke of AMOLF and Universiteit Leiden approach a highly studied exotic elastic material, uncover an intuitive geometrical description of the pronounced—or nonlinear—soft deformations, and show how to activate any of these deformations on-demand with minimal inputs. This new theory reveals that a flexible mechanical structure is governed by some of the same math as electromagnetic waves, phase transitions, and even black holes.

“So many other systems struggle with how to be strong and solid in some ways but flexible and compliant in others, from the human body and micro-organisms to clothing and industrial robots,” said Rocklin. “These structures solve that problem in an incredibly elegant way that permits a single folding mechanism to generate a wide family of deformations. We’ve shown that a single folding mode can transform a structure into an infinite family of shapes.”

New set of chemical building blocks makes complex 3D molecules in a snap

A new set of molecular building blocks aims to make complex chemistry as simple and accessible as a toy construction kit.

Researchers at the University of Illinois Urbana-Champaign and collaborators at Revolution Medicines Inc. developed a new class of chemical building blocks that simply snap together to form 3D with complex twists and turns, and an automated machine to assemble the blocks like a 3D printer for molecules.

This automation could allow chemists and nonchemists alike to develop new pharmaceuticals, materials, diagnostic probes, catalysts, perfumes, sweeteners and more, said study leader Dr. Martin D. Burke, a professor of chemistry at Illinois and a member of the Carle Illinois College of Medicine, as well as a medical doctor. The researchers reported their findings in the journal Nature.

Dr. Stephani Otte, Ph.D. — Chan Zuckerberg Initiative — Measuring Human Biology in Action

Measuring Human Biology in Action, To Cure, Prevent Or Manage All Diseases — Dr. Stephani Otte, Ph.D., Science Program Officer, Imaging, Chan Zuckerberg Initiative.


Dr. Stephani Otte, Ph.D is Science Program Officer, Imaging, at the Chan Zuckerberg Initiative (https://chanzuckerberg.com/), who leads the organization’s Imaging program and is focused on the creation, dissemination, optimization, and standardization of transformative imaging technologies.

Prior to CZI, Dr. Otte was Director of Science at a neuro-technology / microscopy company, Inscopix, involved in accelerating brain science and innovating mini-scope microscope solutions for real-time mapping of the human brain and it’s circuits.

Dr. Otte received her Ph.D. in Neuroscience at the University of California, San Diego, and did postdoctoral fellowships in systems neuroscience at the Salk Institute and University of California, Berkeley.

The Chan Zuckerberg Initiative is an organization established and owned by Dr. Priscilla Chan and her husband, Facebook founder Mark Zuckerberg, with a focus on science, education, immigration reform, housing, criminal justice, and other local issues, with a mission to “build a more inclusive, just, and healthy future for everyone” and to “advance human potential and promote equality in areas such as health, education, scientific research and energy”.

Omicron-specific booster may not be needed, U.S. monkey study finds

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CHICAGO, Feb 4 (Reuters) — A study in monkeys pitting the current Moderna Inc (MRNA.O) COVID-19 booster against an Omicron-specific booster showed no significant differences in protection, suggesting an Omicron-specific booster may not be needed, U.S. government researchers reported on Friday.

The study involved monkeys vaccinated with two doses of Moderna’s vaccine who were dosed nine months later with either the conventional Moderna booster or one specifically targeting the Omicron variant.

The researchers tested various aspects of the animals’ immune responses and exposed them to the virus. They found both boosters produced “comparable and significant increases in neutralizing antibody responses” against all of the variants of concern, including Omicron, according to the study, posted on bioRxiv ahead of peer review.

Keren Haruvi — President, Sandoz US, Head Of North America — Global Generic Medicine Access For All

Pioneering global generic medicine access to improve and extend people’s lives — keren haruvi snir-president, sandoz US, head of north america.


Keren Haruvi is President of Sandoz US and Head of their North America business (https://www.novartis.us/about-us/our-leadership/us-country-l…n-haruvi).

Sandoz is a division of the Novartis Group and a global leader in generic pharmaceuticals and biosimilars and was established in 2003, when Novartis united all of its generics businesses under the name Sandoz – a single global brand with a long history. Since then, Sandoz has grown into a leading global generics business with annual sales of approximately US$10 billion.

In her current role, Keren leads Sandoz’ largest commercial and country organization – the United States – which is responsible for over 35% of Sandoz global revenue. She also oversees Sandoz commercial operations in Canada. In addition to serving on the Novartis Country Leadership Team, Keren is a member of the Global Sandoz Executive Committee.

Prior to joining Sandoz, Keren served as Global Head of M&A at Novartis International AG. Her early career began at Teva Pharmaceutical Industries where she steadily advanced in leadership roles to Senior VP, Global Business Development and Alliance Management.

At Last: New Synthetic Tooth Enamel Is Harder and Stronger Than the Real Thing

Delivering what has been so challenging to produce, researchers present an engineered analog of tooth enamel – an ideal model for designing biomimetic materials – designed to closely mimic the composition and structure of biological teeth’s hard mineralized outer layer. It demonstrates exceptional mechanical properties, they say.

Natural tooth enamel – the thin outer layer of our teeth – is the hardest biological material in the human body. It is renowned for its high stiffness, hardness, viscoelasticity, strength, and toughness and exhibits exceptional damage resistance, despite being only several millimeters thick.

Tooth enamel’s unusual combination of properties is a product of its hierarchical architecture – a complex structure made up of mostly hydroxyapatite nanowires interconnected by an amorphous intergranular phase (AIP) consisting of magnesium-substituted amorphous calcium phosphate. However, accurately replicating this type of hierarchical organization in a scalable abiotic composite has remained a challenge.

Don’t Let The Old Man In: How To Develop A Longevity Mindset And Fight Psychological Aging?

Overall, the results indicate that failure-oriented people are more likely to make poor health choices, presumably due to a lack of proper motivation. When looking at the cause of death for each author, results also showed a strong link between failure motivation and whether or not the death could be considered preventable.

As we can see from this study and many other similar studies, people who expect failure are generally less effective in maintaining good health habits. On the other hand, a positive outlook can play a powerful role in our health decisions. Healthy behaviors include regular exercise, good nutrition, an active lifestyle, and full compliance with medical advice., all of which require strong motivation to ensure we stay the course. A positive mindset also makes us avoid unhealthy activities such as drinking, smoking, and prolonged inactivity. People who develop a failure mindset, whether due to health setbacks, hopelessness, or a general sense of fatalism, often make lifestyle decisions that can undermine their overall health and, as a result, their longevity.

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We often look at our parents and grandparents to predict how long we are going to live and how fast we are going to age. But technology is not standing still and you may benefit from adjusting your longevity expectations and developing a longevity mindset.