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Category: biotech/medical – Page 1,500

World-first quantum dot LED lights made from discarded rice husks

From TVs, to solar cells, to cutting-edge cancer treatments, quantum dots are beginning to exhibit their unique potential in many fields, but manufacturing them at scale would raise some issues concerning the environment. Scientists at Japan’s Hiroshima University have demonstrated a greener path forward in this area, by using discarded rice husks to produce the world’s first silicon quantum dot LED light.

“Since typical quantum dots often involve toxic material, such as cadmium, lead, or other heavy metals, environmental concerns have been frequently deliberated when using nanomaterials,” said Ken-ichi Saitow, lead study author and a professor of chemistry at Hiroshima University. “Our proposed process and fabrication method for quantum dots minimizes these concerns.”

The type of quantum dots pursued by Saitow and his team are silicon quantum dots, which eschew heavy metals and offer some other benefits, too. Their stability and higher operating temperatures makes them one of the leading candidates for use in quantum computing, while their non-toxic nature also makes them suitable for use in medical applications.

“Off the Shelf” Engineered Stem Cells Created To Treat Aggressive Brain Cancer

Investigators uncovered a diagnostic method to identify receptors on cancer cells in the blood, then engineered a cell-based therapy to target and kill tumor cells in the brain, paving the way to clinical testing.

Glioblastomas (GBMs) are highly aggressive cancerous tumors of the brain and spinal cord. Brain cancers like GBM are challenging to treat because many cancer therapeutics cannot pass through the blood-brain barrier, and more than 90% of GBM tumors return after being surgically removed, despite surgery and subsequent chemo-and radiation therapy being the most successful way to treat the disease. In a new study led by investigators at Brigham and Women’s Hospital and Harvard Medical School, scientists devised a novel therapeutic strategy for treating GBMs post-surgery by using stem cells taken from healthy donors engineered to attack GBM-specific tumor cells. This strategy demonstrated profound efficacy in preclinical models of GBM, with 100 percent of mice living over 90 days after treatment. Results will be published today (May 19, 2022) in the journal Nature Communications.

“This is the first study to our knowledge that identifies target receptors on tumor cells prior to initiating therapy, and using biodegradable, gel-encapsulated, ‘off-the-shelf’ engineered stem cell based therapy after GBM tumor surgery,” said Khalid Shah, MS, PhD, director of the Center for Stem Cell and Translational Immunotherapy (CSTI) and the vice chair of research in the Department of Neurosurgery at the Brigham and faculty at Harvard Medical School and Harvard Stem Cell Institute (HSCI).

1st monkeypox case in US this year reported in Massachusetts

A Massachusetts resident has tested positive for monkeypox, health officials confirmed Wednesday, making it the first case of the rare virus detected in the United States this year.

According to a release from the Massachusetts Department of Public Health, the patient is an adult male who recently traveled to Canada. The department completed initial testing Tuesday and was confirmed by the Centers for Disease Control and Prevention.

“The case poses no risk to the public, and the individual is hospitalized and in good condition,” MDPH stated in a press release. “DPH is working closely with the CDC, relevant local boards of health, and the patient’s health care providers to identify individuals who may have been in contact with the patient while he was infectious.”

Gene editing could reverse anxiety and alcohol-use disorder

During that uncomfortable period between puberty and adulthood, the brain undergoes carefully orchestrated changes in gene expression and epigenetic modification. Alcohol, unfortunately, interferes with this biological architecture. Consequently, mistakes are made, and gene expression and modification do not go as planned, leaving the person vulnerable to a lifetime of psychiatric challenges, such as anxiety and alcoholism.

A team of researchers from the University of Illinois Chicago recently found they could reverse these changes in rats via gene editing. If their findings carry through to human studies, gene editing may be a potential treatment for anxiety and alcohol-use disorder in adults who were exposed to binge drinking in their adolescence.

Almost as contagious as measles: Coronavirus spins out worrisome new mutations

The relentless evolution of the coronavirus, which has spawned new variants to fuel fresh surges of disease every four to six months, could in the not-distant future propel the virus to overtake measles as the most contagious of all known infections.

Increasing infectiousness does not necessarily make the virus deadlier, but it could make it harder to control, and leave communities vulnerable to the repeated waves of illness that have defined the pandemic.

The variants now dominating around the world may be five to 10 times more infectious than the original virus that sparked the pandemic in China in late 2019, health experts believe. Lately each variant has outpaced its parent — omicron, with its massive evolutionary jump, was about three times more infectious than delta. Its subvariants — BA.2 and BA.2.12.1, which are driving the latest surge in the Bay Area — are each more infectious still, by 20% to 30%.

Stimulating Brain Circuits Promotes Neuron Growth in Adulthood, Improving Cognition and Mood

Summary: Researchers used optogenetics techniques to stimulate specific brain areas to increase neurogenesis and the production of neural stem cells to improve memory, cognition, and emotional processing in animal models.

Source: UNC Health Care.

We humans lose mental acuity, an unfortunate side effect of aging. And for individuals with neurodegenerative conditions such as Alzheimer’s and Parkinson’s, the loss of cognitive function often accompanied by mood disorders such as anxiety is a harrowing experience. One way to push back against cognitive decline and anxiety would be to spur the creation of new neurons.

Uploading Memories: Elon Musk’s Brain Chip (Neuralink Future Technology)

The long term goal for Elon Musk and brain to computer interfaces (brain chips) is to merge our minds with artificial intelligence. While the short term goal for Neuralink and other companies is to help people with medical issues.

This short documentary video takes a look at connecting our brains to computers, and how this works is explained. We also take a look at the downsides of people connecting their brains, the technology being used today, and Elon Musk’s thoughts.

Other topics in the video include:
• How in the future we could download and upload our memories and dreams so they are not forgotten.
• The different types of brain to computer implants and devices.
• Updates (demonstrating and testing on pigs, and soon humans) and a summery of where we are today with this technology.
• Tutorial on how it works.
• And what other sci-fi like things will brains connected to computers allow us humans to do.

First 2022 US case of Monkeypox confirmed

Massachusetts health officials on Wednesday confirmed a single case of monkeypox virus infection in an adult male who health officials said recently traveled to Canada.

The Department of Public Health said monkeypox is a rare but potentially serious viral illness that typically begins with flu-like symptoms and swelling of the lymph nodes. It progresses to a rash on the face and body, with most infections lasting two to four weeks.

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