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Category: biotech/medical – Page 1,473

Supercomputer Helps Understand the Physics of Thought

Decades of research has led to a thorough understanding of the main protein players and the broad strokes of membrane fusion for synaptic transmission. Bernard Katz was awarded the 1970 Nobel Prize in Medicine in part for demonstrating that chemical synaptic transmission consists of a neurotransmitter-filled synaptic vesicle fusing with the plasma membrane at nerve endings and releasing its content into the opposing postsynaptic cell. And Rizo-Rey’s longtime collaborator, Thomas Südhof, won the Nobel Prize in Medicine in 2013 for his studies of the machinery that mediates neurotransmitter release (many with Rizo-Rey as a co-author).

But Rizo-Rey says his goal is to understand the specific physics of how the activation process of thought occurs in much more detail. “If I can understand that, winning the Nobel Prize would just be a small reward,” he said.

Recently, using the Frontera supercomputer at the Texas Advanced Computing Center (TACC), one of the most powerful systems in the world, Rizo-Rey has been exploring this process, creating a multi-million atom model of the proteins, the membranes, and their environment, and setting them in motion virtually to see what happens, a process known as molecular dynamics.

The Age of Superhumans — Gene Editing Through CRISPR & AI

Superhumans are coming! Various technological advances in the field of medicine through AI and CRISPR are going to radically alter our understanding of what it means to be human. AI and Crispr technology have been making revolutionary changes to the field of medicine. Artificial intelligence is being applied in identification of harmful genes and treatment of disease.

Multiple new gene editing technologies in addition to artificial intelligence will cause major changes in healthcare.
The gene-editing tool CRISPR, short for clustered regularly interspaced short palindromic repeats, could help us to reprogram life. It gives scientists more power and precision than they have ever had to alter human DNA.

Could it be conceivable that at one point in the future we could increase the average IQ of the population?
CRISPR technology in the future could enable efficient and affordable treatment of many diseases. It will be also probably used to enhance our intelligence.

CRISPR was originally designed as a technique for editing the DNA of living organisms, but its uses and capabilities have expanded substantially. It is now used widely in biomedical research, including research into human genetics. One of the main issues concerning technologies such as CRISPR-Cas9 is accuracy and safety, as mistakes can have significant and dangerous consequences when it comes to an individual’s genome.

David Sinclair explains the mind boggling breakthroughs of medicine in recent times.

The possibility of altering the sequences of genes and correcting the mistakes that were previously irreversible opens many new possibilities for research. Nevertheless, for now, genetic editing technology is still incapable of making the hundreds of changes presumably necessary to make a superintelligent human. But the corresponding ethical issues deserve serious attention before these capabilities become a reality.

Continue reading “The Age of Superhumans — Gene Editing Through CRISPR & AI” | >

The Rise of Supersoldiers — How AI Changes Everything

Artificial Intelligence is touching almost every aspect of our lives. It’s reasonable to expect AI influence will only increase in the future. One of many fields heavily influenced by AI is the military. Particularly in the development of Supersoldiers. The notion of super-soldiers enhanced with biotechnology and cybernetics was once only possible in the realm of science fiction. But it may not be too long before these concepts become a reality.

A new worldwide arms race is pitting countries against each other to be the first to successfully create real genetically modified super soldiers by using tools such as CRISPR. Understandably many of these human enhancement technologies raise health and safety questions and it is more likely these enhancements will first gain traction in countries that do not place as much weight on ethical concerns.

According to US Intelligence, China has conducted “human testing” on members of the People’s Liberation Army in hope of developing soldiers with “biologically enhanced capabilities.

This has made the U.S. military’s top intelligence agencies increasingly worried but the Pentagon has significantly invested in its own research in AI and in the extension of the human senses beyond their current physical limitations, to provide soldiers with superhuman abilities.

The basics of brain-machine interfaces with AI are being developed for the military, and if the results are as successful as scientists hope they will be, soldiers could one day be enhanced with cybernetics, effectively becoming trans-human soldiers.

The US Military is also examining newly scientific tools, like genetic engineering, brain chemistry, and shrinking robotics, for even more dramatic enhancements. But most of this advanced technology remains classified.

Continue reading “The Rise of Supersoldiers — How AI Changes Everything” | >

Robotic Armband Shows Promise for Advanced Dexterity

AZoRobotics speaks with Dr. Erik Enegberg from Florida Atlantic University about his research into a wearable soft robotic armband. This could be a life-changing device for prosthetic hands users who have long-desired advances in dexterity.

Typing on a keyboard, pressing buttons on a remote control, or braiding a child’s hair has remained elusive for prosthetic hand users. How does the loss of tactile sensations impact limb-absent people’s lives?

Losing the sensation of touch has a profound impact on people’s lives. Some of the things that may seem simple and a part of everyday life, such as stroking the fur of a pet or the skin of a loved one, are a meaningful and fundamental way to connect with those around us for others. For example, a patient with a bilateral amputation has previously expressed concerns that he might hurt his granddaughter by accidentally squeezing her hand too tightly as he has lost tactile sensation.

Lyme Disease Is Even More Common Than Experts Realized, New Research Finds

It’s extremely important to check yourself for ticks this summer.

Up to 14.5% of the global population may have already had Lyme disease, according to a new meta-analysis published in BMJ Global Health. The researchers behind the report analyzed 89 previously published studies to calculate the figure, which sheds a harrowing light on the worldwide toll of the tick-borne illness.

From 1991 to 2018, the incidence of Lyme disease in the United States nearly doubled, according to data from the United States Environmental Protection Agency (EPA). In 1991, there were nearly four reported cases per 100,000 people; that number jumped to about seven cases per 100,000 people by 2018. The Centers for Disease Control and Prevention (CDC) estimates that about 470,000 Americans are diagnosed and treated for Lyme disease each year.

The bacterium that most commonly causes Lyme, Borrelia burgdorferi, is transmitted to humans via the bite of an infected black-legged tick, also known as a deer tick. These especially tiny ticks are often found in the Northeast, Mid-Atlantic, Upper Midwest, and Pacific Coast of the United States, per the U.S. National Library of Medicine (NLM). Once a person has been infected, they may develop short-term, flu-like symptoms including fever, headache, and fatigue, as well as a signature bull’s-eye-shaped rash that appears in up to 80% of Lyme disease cases, according to the CDC. In rare instances, when Lyme is left untreated, a person may experience long-term, potentially life-threatening complications, including joint pain, severe headaches and neck stiffness, heart issues, and inflammation of the brain and spinal cord, among others.

Researchers discover two important novel aspects of APOE4 gene in Alzheimer’s patients

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia, affecting more than 5.8 million individuals in the U.S. Scientists have discovered some genetic variants that increase the risk for developing Alzheimer’s; the most well-known of these for people over the age of 65 is the APOE ε4 allele. Although the association between APOE4 and increased AD risk is well-established, the mechanisms responsible for the underlying risk in human brain cell types has been unclear until now.

Researchers from Boston University School of Medicine (BUSM) have discovered two important novel aspects of the gene: 1) human genetic background inherited with APOE4 is unique to APOE4 patients and 2) the mechanistic defects due to APOE4 are unique to human cells.

Our study demonstrated what the APOE4 gene does and which brain cells get affected the most in humans by comparing human and mouse models. These are important findings as we can find therapeutics if we understand how and where this risk gene is destroying our brain.

Beyond longevity: The DIY quest to cheat death and stop aging

At 79, he’s already outlived the CDC’s official life expectancy by two years and he has no intention of dying — or even slowing down — anytime soon. An active man, Scott jets between his homes in upstate New York and Florida, flies to exotic locations such as Panama City for business and still finds time for the odd cruise. His secret? A DIY regime of self-experimentation and untested therapies he believes will keep him going well past the next century.

Self-experimenters litter the history of medical science. Dentist Horace Wells dosed himself with nitrous oxide in 1,844 to see if it could kill pain, Nicholas Senn inflated his innards with hydrogen a few decades later to work out if it could diagnose a ruptured bowel, and more recently, Barry Marshall drank a solution containing H. pylori in 1985 to prove the bacterium caused ulcers.

These scientists risked their own health to make a medical breakthrough or prove a theory, but Scott is not a scientist. He’s an amateur enthusiast, also known as a biohacker. Biohackers engage in DIY biology, experimenting on themselves to enhance their brain and body. And many of them — like Scott — see longevity as the ultimate prize.

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