Lifeboat Foundation

COVID-19 has led to limited food budgets, and shelter-in-place adds a layer of complexity to buying and planning meals. At the same time, we’re bombarded with ads shouting “Take this supplement to boost your immunity!” So, what’s a person to do?

Filling your cart with the basics might make you feel secure in the short term. But as Dr. Chu found, it’s a different ballgame when you get these items home. Can you make healthy meals with shelf-stable foods? Will the family eat your creation? And does food really boost our immunity? Yes, yes, and yes – over time.

I field questions like these often as director of UT Southwestern’s Culinary Medicine Program. We help people transform food preparation and eating into a healthier part of their daily lives. The program focuses on creating budget-friendly meals with shelf-stable ingredients, as well as mindful eating practices.

Continue reading “Quarantine cuisine: Easy meals to support a healthy immune system” »

Researchers at Karolinska Institutet in Sweden have identified a small neutralizing antibody, a so-called nanobody, that has the capacity to block SARS-CoV-2 from entering human cells. The researchers believe this nanobody has the potential to be developed as an antiviral treatment against COVID-19. The results are published in the journal Nature Communications.

“We hope our findings can contribute to the amelioration of the COVID-19 pandemic by encouraging further examination of this nanobody as a therapeutic candidate against this viral infection,” says Gerald McInerney, corresponding author and associate professor of virology at the Department of Microbiology, Tumor and Cell Biology at Karolinska Institutet.

The search for effective nanobodies—which are fragments of antibodies that occur naturally in camelids and can be adapted for humans—began in February when an alpaca was injected with the new coronavirus’ spike protein, which is used to enter our cells. After 60 days, blood samples from the alpaca showed a strong immune response against the spike protein.

A new application of the CRISPR/Cas molecular scissors promises major progress in crop cultivation. At Karlsruhe Institute of Technology (KIT), researchers from the team of molecular biologist Holger Puchta have succeeded in modifying the sequence of genes on a chromosome using CRISPR/Cas. For the first time worldwide, they took a known chromosome modification in the thale cress model plant and demonstrated how inversions of the gene sequence can be undone and inheritance can thus be controlled specifically. The results are published in Nature Communications.

About 5,000 years ago, genetic information of thale cress was modified. To date, it has spread widely and is of major interest to science. On the chromosome 4 of the plant, a so-called inversion occurred: The chromosome broke at two points and was reassembled again. The broken out section was reinserted, but rotated by 180°. As a result, the sequence of genes on this chromosome section was inverted. This chromosome mutation known as “Knob hk4S” in research is an example of the fact that evolution cannot only modify the genetic material of organisms, but determine it for a long term. “In inverted sections, genes cannot be exchanged between homologous chromosomes during inheritance,” molecular biologist Holger Puchta, KIT, explains.

This is a part of a longer interview which you can watch in parts or listen in one go though it is posted on youtube as audio only for the latter.

Let’s say we find a way to reverse aging. How far could we wind things back and when should we do it?

Continue reading “How Far We Can Wind Back The Clock Ft. David Sinclair | Think Inc.” »

HSCI scientists have combined organ-on-a-chip and stem-cell technologies to make a powerful tool for diabetes research and beta-cell transplantation.

Low-temperature plasmas offer promise for applications in medicine, water purification, agriculture, pollutant removal, nanomaterial synthesis and more. Yet making these plasmas by conventional methods takes several thousand volts of electricity, says David Go, an aerospace and mechanical engineer at the University of Notre Dame. That limits their use outside high-voltage power settings.

In work supported by the U.S. National Science Foundation, Go and a team of researchers conducted research that explores making plasma devices that can be operated without electrical power—they need only human or mechanical energy.

Their paper in Applied Physics Letters introduces a strategy the scientists call “energy-conversion plasma” as an alternative to producing “transient spark” discharges without the need for a very high-voltage power supply.

Women with Alzheimer’s disease tend to live longer than men with the disease — and a new study suggests that a gene on the X chromosome may help explain why.

Each person typically has one pair of sex chromosomes in each cell of their body. People assigned female at birth typically have two X chromosomes, while people assigned male at birth typically have one X chromosome and one Y chromosome.

Researchers say a gene called KDM6A may explain why women with Alzheimer’s disease tend to live longer than men with the same condition.

To overcome preexisting immunity that cripples the adenovirus vectors used in gene therapy and vaccines, scientists at the University of Pittsburgh created a CRISPR-based system that briefly suppresses the genes that cause the problem. The method improved gene therapy uptake in mice and is being developed by startup SafeGen.

The lockdown “cure” for COVID may have caused more damage than the disease…