Summary: Study identifies genes that become activated in the brain prior to the initiation of severe repetitive behaviors associated with addiction, ASD, and schizophrenia.
Source: MIT
Extreme repetitive behaviors such as hand-flapping, body-rocking, skin-picking, and sniffing are common to a number of brain disorders including autism, schizophrenia, Huntington’s disease, and drug addiction. These behaviors, termed stereotypies, are also apparent in animal models of drug addiction and autism.
Mark my words. When the first real treatment happens people will change their tune. They need to see it work and see that it’s safe.
A new study of about 900 U.S. adults has found that only 33% would use a hypothetical life extension treatment that would allow them “to live forever,” even if it were available today. About 42% said they would not use it, and 25% said they were unsure.
The study, published by University of Texas researchers Michael Barnett and Jessica Helphrey, appeared in the Journal of Aging Studies on April 21.
Circa 2019
Several recent studies have claimed that cancer cells can be reprogrammed into induced pluripotent stem cells (iPSCs). However, in most cases, cancer cells seem to be resistant to cellular reprogramming. Furthermore, the underlying mechanisms of limited reprogramming in cancer cells are largely unknown. Here, we identified the candidate barrier genes and their target genes at the early stage of reprogramming for investigating cancer reprogramming.
We tried induction of pluripotency in normal human fibroblasts (BJ) and both human benign (MCF10A) and malignant (MCF7) breast cancer cell lines using a classical retroviral reprogramming method. We conducted RNA-sequencing analysis to compare the transcriptome of the three cell lines at early stage of reprogramming.
We could generate iPSCs from BJ, whereas we were unable to obtain iPSCs from cancer cell lines. To address the underlying mechanism of limited reprogramming in cancer cells, we identified 29 the candidate barrier genes based on RNA-sequencing data. In addition, we found 40 their target genes using Cytoscape software.
Instead of putting genetic instructions into people whose cells then make a viral protein, the vaccines from Novavax, Medicago and Sanofi carry a spike protein payload.
The Delta B.1.617 variant has been suggested to be more transmissible than other variants of concern, and has already spread to all ten provinces and one territory.
Researchers at DTU Health Tech have developed a new material that can facilitate a near-perfect merger between machines and the human body for diagnostics and treatment.
A DTU research team consisting of Malgorzata Gosia Pierchala, Firoz Babu Kadumundi, and Mehdi Mehrali from #TeamBioEngine headed by Alireza Dolatshahi-Pirouz, have developed a new material—CareGum—that among other things has potential for monitoring motor impairment associated with neurological disorders such as Parkinson’s.
Posted in biotech/medical, genetics, internet, life extension
Don’t worry you haven’t stumbled onto that strange part of the internet again, but it is true that we never truly did sequence the entire Human genome. For you see what was completed in June 2000 was the so called ‘first draft’, which constituted roughly 92% of genome. The problem with the remaining 8% was that these were genomic ‘dead zones’, made up of vast regions of repeating patterns of nucleotide bases that made studying these regions of the genome effectively impossible with the technology that was available at the time.
However, recent breakthroughs in high throughput nanopore sequencing technology have allowed for these so call dead zones to be sequences. Analysing these zone revealed 80 different genes which had been missed during the initial draft of the Human genome. Admittedly this is not many considering that the other 92% of the genome contain 19889 genes, but it may turn out that these genes hold great significance, as there are still many biological pathways which we do not fully understand. It is likely that many of these genes will soon be linked with what are known as orphan enzymes, which are proteins that are created from an unidentified gene, which is turn opens up the door to studying these enzymes more closely via controlling their expression.
So how does this discovery effect the field of regenerative medicine? Well the discovery of these hidden genes is potentially very significant for our general understand of Human biology, which in turn is important for our understanding of how we might go about fixing issues which arise. Possibly more important that the discovery of these hidden genes, is the milestone this sequencing represents in our ability to study our genomes quickly and efficiently with an all-inclusive approach. The vast amount of data that will soon be produced via full genome analysis will go a long way towards understanding the role that genetics play in keeping our bodies healthy, which in turn will allow us to replicate and improve upon natural regenerative and repair mechanisms. It might even allow us to come up with some novel approaches which have no basis in nature.
When attacked by chemotherapy, all cancer cells have the ability to start hibernating in order to wait out the threat, finds new research.
Researchers discover that cancer cells go into hibernation to avoid chemotherapy effects.
Papers referenced in the video:
Sirtuins, Healthspan, and Longevity in Mammals.
https://www.sciencedirect.com/science/article/pii/B9780124115965000034
Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH
https://pubmed.ncbi.nlm.nih.gov/24011076/
Resveratrol improves health and survival of mice on a high-calorie diet.
