Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical – Page 139

This allows them to see how bacteria activate different genes in response to their environment, offering insights into microbial behavior, antibiotic resistance, and infection strategies.

How Bacteria Organize Their Activities

How do bacteria — whether beneficial ones in our bodies or harmful disease-causing strains — coordinate their activities? A recent study has provided new insights by combining advanced genomic-scale microscopy with an innovative technique to track which genes bacteria activate in different conditions and environments. Published recently in the journal Science, this breakthrough is set to advance bacterial research significantly.

Read more | >

Scientists explored Human Accelerated Regions (HARs), genetic regulators that tweak existing genes rather than introducing new ones. Using cutting-edge techniques, they mapped nearly all HAR interactions, revealing their role in brain development and neurological disorders like autism and schizophrenia.

Decoding the Genetic Evolution of the Human Brain

A new Yale study offers a deeper understanding of the genetic changes that shaped human brain evolution and how this process differed from that of chimpanzees.

Read more | >

Scientists have discovered a remarkable new form of symbiosis — a bacterium that lives inside a single-celled organism (a ciliate) and provides it with energy. Unlike mitochondria, which use oxygen, this microbe powers its host by breathing nitrate.

Initially found in a freshwater lake, researchers set out to determine how widespread these microbes are. To their surprise, they uncovered them in diverse environments worldwide, from lakes and groundwater to even wastewater. This discovery challenges our understanding of microbial partnerships and reveals how these tiny organisms play a hidden yet significant role in global ecosystems.

A New Symbiotic Discovery

Read more | >

The small trial showed durable results in nine patients three years after treatment with the experimental vaccine

Findings published this week in the journal Nature showed how personalized therapeutic vaccines can change the course of kidney cancer, though longer trials will be needed to confirm this approach.

The vaccines were tailored to particular mutations in the tumors of kidney cancer patients using so-called neoantigens, which are unique proteins or peptides generated by tumor cells that differ from those found in normal tissues. Not only do the neoantigens shield against cancer recurrence, but they also prevent unintended damage to healthy cells, which is a major concern with traditional chemotherapy regimens.

Read more | >

When the immune system becomes unbalanced, it can lead to serious problems, such as type 1 diabetes, other autoimmune diseases, or organ rejection after a transplant. Current treatments often involve suppressing the entire immune system, which can cause severe side effects, including a higher risk of infections and other complications. A better approach would be to regulate the immune response in a precise and targeted way. That’s exactly what researchers have now achieved by engineering specialized immune cells designed to restore balance without compromising overall immunity.

Engineering Immune Cells to Protect Rather Than Attack

The immune system defends the body against viruses, bacteria, and other threats by identifying harmful invaders and mounting a response. It also distinguishes between the body’s own cells and foreign ones, adjusting its reaction as needed. However, when the immune system becomes dysregulated, it can mistakenly attack the body’s own tissues. This happens in conditions like type 1 diabetes, where the immune system destroys insulin-producing beta cells in the pancreas. It can also reject transplanted organs, treating them as foreign threats. While immunosuppressant drugs can prevent these harmful reactions, they come with serious risks, including increased vulnerability to infections and cancer.

Read more | >

Our guts are home to trillions of bacteria, and research over the last few decades has established how essential they are to our physiology—in health and disease. A new study from EMBL Heidelberg researchers shows that gut bacteria can bring about profound molecular changes in one of our most critical organs—the brain.

The new study, published in the journal Nature Structural & Molecular Biology, is the first to show that bacteria living in the gut can influence how proteins in the brain are modified by carbohydrates—a process called glycosylation. The study was made possible by a new method the scientists developed—DQGlyco—which allows them to study glycosylation at a much higher scale and resolution than previous studies.

Read more | >

VeinViewer® Flex is a highly portable vascular access imaging device that can help you find the optimal venipuncture site and avoid potential complications.

With HD imaging and Df² technology, this small VeinViewer model is the brightest and only handheld vein illuminator that provides benefits for all patients during the entire Pre-, During-and Post-vascular access procedure. It is ideal for alternate care facilities, such as surgery and blood/plasma centers, as well as home healthcare and Emergency Medical Services (EMS), VeinViewer Flex is designed for durability and maximum portability. Flex is also suited for hospital departments such as the Emergency Department and NICU where space requirements and speed of assessment demand an ultra-portable and reliable vein finder.

How Does It Work?

Read more | >

A new mathematical model sheds light on how the brain processes different cues, such as sights and sounds, during decision making. The findings from Princeton neuroscientists may one day improve how brain circuits go awry in neurological disorders, such as Alzheimer’s, and could help artificial brains, like Alexa or self-driving car technology, more helpful.

Read more | >

Before joining MPFI, Wang was a research scientist at the Janelia Research Campus of Howard Hughes Medical Institute, working with Dr. Jeffery Magee and previously with Dr. Eva Pastalkova. At Janelia, she studied the hippocampal neuronal activities that represent memory traces. In particular, she employed memory tasks that can reversibly toggle the influence of sensory inputs on and off and isolated neuronal activities associated with internally stored memory.

Wang was trained as an electrical engineer. She completed her graduate study under the mentorship of Drs. Shih-Chii Liu, Tobi Delbruck and Rodney Douglas at the Swiss Federal Institute of Technology Zurich (ETHZ). During her Ph.D. training, she designed brain-inspired computational systems on silicon chips. These fully reconfigurable systems incorporated electronic circuits of a network of neurons with dendrites and synapses. Using these systems as simulation tools, she also investigated the computational principles native to a neuron with active dendrites.

Read more | >